Task-free Presurgical Evaluation of Lateral, Eloquent Cortex & Epileptic Foci

外侧口才皮层的无任务术前评估

• 批准号: 8233306
• 负责人: Hesheng Liu
• 金额: $ 17.91万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2016-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8233306
• 关键词: Address; Anatomy; Area; Barbiturates; Brain; Brain Diseases; Brain Mapping; Brain imaging; Cerebral hemisphere; Clinical; Clinical effectiveness; Epilepsy; Evaluation; Event; Excision; Foundations; Foxes; Functional Magnetic Resonance Imaging; Goals; Gold; Handedness; Image; Imaging Techniques; Individual; Language; Language Disorders; Lateral; Lesion; Link; Location; MRI Scans; Magnetic Resonance; Magnetic Resonance Imaging; Magnetoencephalography; Maps; Measurement; Measures; Memory; Methods; Motor; Neurosciences Research; Operating Rooms; Operative Surgical Procedures; Participant; Patient Participation; Patients; Postoperative Period; Procedures; Research; Research Personnel; Research Project Grants; Rest; Risk; Series; System; Techniques; Testing; Time; Tissues; Validity and Reliability; barbituric acid salt; base; career; clinical application; design; improved; indexing; insight; neuroimaging; new technology; novel; novel strategies; programs; public health relevance; tumor

DESCRIPTION (provided by applicant): Pre-surgical evaluation benefits from information about the location of functional brain systems and dysfunctional tissue. Recently, methods based on analysis of spontaneous activity measured by functional MRI have shown promise for identifying brain systems in subjects resting and while asleep. Here we will develop and evaluate a novel method using rest-state intrinsic activity to map multiple systems within the brain including language, memory, and motor systems. Specifically, this project aims to address three critical challenges in pre-surgical mapping. First, this project will seek to develop a new language and memory lateralization technique as a candidate to replace the traditional invasive Wada test. Second, we hypothesize that essential areas of cortex can be mapped using intrinsic functional connectivity linked to specific brain systems. Finally, by assessing the disruption of functional connectivity, we will seek to localize brain lesions and epileptogenic cortex. This project proposes a new approach for pre-surgical mapping for patients with brain lesions and has the potential to significantly improve surgical planning. PUBLIC HEALTH RELEVANCE: This project aims to replace the traditional pre-surgical mapping by providing a means to determine functional laterality, eloquent cortex and epileptic foci simultaneously and with minimal task requirements.

描述（由申请人提供）：手术前评估受益于有关功能性大脑系统和功能障碍组织的位置的信息。最近，基于功能性 MRI 测量的自发活动分析的方法有望识别受试者休息和睡眠时的大脑系统。在这里，我们将开发和评估一种利用静息状态内在活动来映射大脑内多个系统（包括语言、记忆和运动系统）的新方法。具体来说，该项目旨在解决术前绘图中的三个关键挑战。首先，该项目将寻求开发一种新的语言和记忆偏侧化技术，作为替代传统侵入性 Wada 测试的候选技术。其次，我们假设可以使用与特定大脑系统相关的内在功能连接来映射皮层的重要区域。最后，通过评估功能连接的破坏，我们将寻求定位大脑病变和致癫痫皮层。该项目提出了一种针对脑部病变患者进行术前绘图的新方法，并有可能显着改善手术计划。 公共健康相关性：该项目旨在通过提供一种以最少的任务要求同时确定功能偏侧、雄辩皮层和癫痫病灶的方法来取代传统的手术前定位。