Health Disparities in Cardiovascular Disease Risk: From Genes to Neighborhoods

心血管疾病风险的健康差异：从基因到社区

• 批准号: 8368244
• 负责人: Mahasin S Mujahid
• 金额: $ 13.75万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8368244
• 关键词: Accounting; Affect; Behavioral; Biological; Blood Pressure; Body mass index; California; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Cohort Studies; Complex; Computerized Medical Record; Data; Databases; Diet; Disease; Environment; Environmental Risk Factor; Epidemiology; Epigenetic Process; Etiology; Exposure to; Functional disorder; Future; Genes; Genetic; Goals; Health; Hypertension; Individual; Investigation; K-Series Research Career Programs; Link; Measures; Mentors; Modeling; National Heart, Lung, and Blood Institute; Neighborhoods; Obesity; Other Genetics; Outcome; Outcome Study; Pathway interactions; Physical activity; Population; Population Heterogeneity; Public Health; Publishing; Questionnaires; Research; Research Project Grants; Resources; Risk Factors; Sampling; Smoking Behavior; Source; Specimen; Time; Training; Training Support; Universities; Work; abstracting; administrative database; base; cardiovascular disorder risk; career; design; gene environment interaction; gene interaction; genetic epidemiology; genome wide association study; health disparity; population health; professor; programs; racial and ethnic; racial/ethnic difference; socioeconomics

DESCRIPTION (provided by applicant): Cardiovascular Diseases (CVD) are a major public health concern as the leading cause of death and as a major source of racial/ethnic health disparities. Because CVD is a multi-factorial disease, a true understanding of its etiology requires investigations of interactions among many genetic and environmental factors. Thus, the overall goal of this study is to advance our understanding of how multi-level factors (from genes to neighborhoods) synergistically affect CVD. The specific aims of the proposed research are to: 1) develop measures of neighborhood socioeconomic, built/physical, and social environments, 2) examine cross- sectional and longitudinal associations between genetic and neighborhood factors, and their interactions in relation to CVD risk factors, and 3) examine racial/ethnic differences in CVD risk factors and determine if these differences are explained by neighborhood-gene interactions. These aims will be achieved through the merging of data from the Research Program on Genes, Environment, and Health (RPGEH), with data derived from available sources on neighborhoods and the built environment. The RPGEH is one of the largest research resources in the U.S. designed to examine genetic and environmental determinants of common diseases. The candidate, Mahasin Mujahid, is an Assistant Professor of Epidemiology at the University of California, Berkeley. The proposed NHLBI Mentored Career Development Award (K01) will provide Dr. Mujahid with the unique opportunity to augment her current expertise in general epidemiology, social epidemiology, and population health with new training in cardiovascular pathophysiology, genetic epidemiology, and statistical genetics. Moreover, Dr. Mujahid will receive the necessary support and training to work towards her long-term career goal of establishing an independent research program on the social epidemiology of cardiovascular disease with an emphasis on the underlying biological, genetic, and epigenetic pathways linking social factors to CVD. (End of Abstract)

描述（由申请人提供）：心血管疾病（CVD）是一个主要的公共卫生问题，是死亡的主要原因，也是种族/民族健康差异的主要来源。由于CVD是一种多因素疾病，要真正了解其病因，需要调查许多遗传和环境因素之间的相互作用。因此，本研究的总体目标是促进我们对多水平因素（从基因到社区）如何协同影响CVD的理解。拟议研究的具体目标是：1）制定邻里社会经济，建筑/物理和社会环境的措施，2）检查遗传和邻里因素之间的横截面和纵向关联，以及它们与CVD风险因素的相互作用，3）检查CVD风险因素的种族/民族差异，并确定这些差异是否由邻里基因相互作用解释。这些目标将通过合并来自基因，环境和健康研究计划（RPGEH）的数据，以及来自社区和建筑环境的可用数据来实现。RPGEH是美国最大的研究资源之一，旨在研究常见疾病的遗传和环境决定因素。候选人Mahasin Mujahid是加州大学伯克利分校的流行病学助理教授。拟议的NHLBI指导职业发展奖（K 01）将为Mujahid博士提供独特的机会，通过心血管病理生理学，遗传流行病学和统计遗传学的新培训来增强她目前在普通流行病学，社会流行病学和人口健康方面的专业知识。此外，Mujahid博士将获得必要的支持和培训，以实现她的长期职业目标，即建立一个关于心血管疾病社会流行病学的独立研究计划，重点是将社会因素与CVD联系起来的潜在生物学，遗传学和表观遗传学途径。 (End摘要）