Critical Care Therapies Associated with Longterm Outcomes After Acute Lung Injury

与急性肺损伤后长期结果相关的重症监护治疗

• 批准号: 8286930
• 负责人: Erin Kathryn Kross
• 金额: $ 13.29万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8286930
• 关键词: Acute Lung Injury; Anxiety; Area; Award; Biometry; Blood Transfusion; Caring; Clinical Investigator; Clinical Research; Cohort Studies; Communication; Critical Care; Critical Illness; Data Analyses; Data Collection; Decision Making; Development; Development Plans; Educational Curriculum; Epidemiology; Family; Family member; Funding; Future; Goals; Health Services Research; Hypoglycemia; Intensive Care Units; Intervention; Lead; Light; Medical Records; Mental Depression; Mental Health; Mentored Patient-Oriented Research Career Development Award; Mentors; Morbidity - disease rate; Outcome; Outcome Assessment; Pathway interactions; Patient Care; Patients; Physicians; Post-Traumatic Stress Disorders; Publishing; Qualitative Methods; Quality of life; Research; Research Project Grants; Research Proposals; Risk Factors; Role; Scientist; Sedation procedure; Statistical Methods; Surveys; Survivors; Symptoms; Syndrome; United States; abstracting; adverse outcome; base; career; career development; design; experience; functional outcomes; functional status; health related quality of life; high risk; improved; innovation; loved ones; novel; patient oriented research; prospective; psychologic; psychological distress; psychological outcomes; public health relevance; skills; success; successful intervention; symposium; theories; therapy development; therapy outcome

DESCRIPTION (provided by applicant): This K-23 award will provide an opportunity for Dr. Kross to become an independent physician scientist focused on improving long-term outcomes for patients with acute lung injury. Through her patient-oriented research proposal, Dr. Kross will identify modifiable critical care risk factors for psychological and functional morbidity among patients with acute lung injury and their family members. Importantly, in order to develop innovative approaches for intervention, she will also evaluate a novel hypothesis of psychological and functional morbidity shared between patients experiencing critical illness and critical care therapies and their families. With the goal of developing a career studying therapies and outcomes for patients with acute lung injury, as well as their families, Dr. Kross proposes an integrated curriculum consisting of practical experience in designing, conducting and publishing clinical research projects; coursework in epidemiology, biostatistics and health services research; and intensive mentoring by experts in the psychological and functional outcomes of critical illness. Dr. Kross will use this K23 award to become an independently funded clinical investigator with skills in the design and conduct of clinical studies of patients with acute lung injury and their families. Moreover, she will develop expertise in survey-based outcome assessment, standardized medical record abstraction, clustered and longitudinal statistical methods, and qualitative data collection and analysis. This career development plan will lead to a successful and independent research career focused on understanding and improving long-term outcomes of acute lung injury. To achieve these goals Dr. Kross will conduct a prospective cohort study to: 1) identify associations between modifiable critical care predictors of psychological and functional morbidity for patients with acute lung injury; 2) identify associations between modifiable critical care predictors of psychological and functional morbidity for families of patients of acute lung injury; 3) identify associations between psychological and functional morbidity for patients surviving acute lung injury and psychological and functional morbidity for their families; and 4) use qualitative methods to explore potential critical care approaches to interventions that will improve long-term outcomes for patients and their families. This project has important implications for patients with acute lung injury and their families. The identification of modifiable critical care risk factors for long-term psychological symptoms and decreased functional status for both patients with acute lung injury and their families will inform the development of future critical care interventions to reduce these consequences of acute lung injury. PUBLIC HEALTH RELEVANCE: Acute lung injury is a common syndrome of critical illness in the United States. While morbidity is high, the majority of patients with acute lung injury will survive their illness, and, therefore, the long-term consequences of this illness become important. This project has the goal of better understanding the risk factors for long-term psychological symptoms and decreased quality of life among patients with acute lung injury and their family members, and informing the development of interventions that will decrease psychological symptoms and improve quality of life of patients with acute lung injury and their families. (End of Abstract)

描述（由申请人提供）：这个K-23奖将为Kross博士提供一个机会，使其成为一名独立的医生科学家，专注于改善急性肺损伤患者的长期预后。通过她以患者为导向的研究建议，Kross博士将确定急性肺损伤患者及其家人心理和功能发病率的可改变的重症监护风险因素。重要的是，为了开发创新的干预方法，她还将评估一种新的假设，即经历重症疾病和重症监护治疗的患者及其家人之间共享的心理和功能性发病率。Kross博士提出了一个综合课程，包括设计，实施和出版临床研究项目的实践经验;流行病学，生物统计学和卫生服务研究的课程;以及重症疾病的心理和功能结果专家的强化指导。Kross博士将利用这一K23奖项成为一名独立资助的临床研究者，拥有设计和开展急性肺损伤患者及其家属临床研究的技能。此外，她将发展基于调查的结果评估，标准化的病历摘要，集群和纵向统计方法，以及定性数据收集和分析的专业知识。这个职业发展计划将导致一个成功的和独立的研究生涯，专注于了解和改善急性肺损伤的长期结果。为了实现这些目标，Kross博士将进行一项前瞻性队列研究，以：1）确定急性肺损伤患者心理和功能发病率的可修改重症监护预测因子之间的关联; 2）确定急性肺损伤患者家属心理和功能发病率的可修改重症监护预测因子之间的关联; 3）确定急性肺损伤幸存患者的心理和功能发病率与其家人的心理和功能发病率之间的关系;和4）使用定性方法来探索潜在的重症监护干预方法，以改善患者及其家属的长期结局。该项目对急性肺损伤患者及其家属具有重要意义。确定急性肺损伤患者及其家属长期心理症状和功能状态下降的可改变的重症监护风险因素，将为未来重症监护干预措施的制定提供信息，以减少急性肺损伤的这些后果。 公共卫生相关性： 急性肺损伤在美国是一种常见的危重病综合征。虽然发病率很高，但大多数急性肺损伤患者会在疾病中存活，因此，这种疾病的长期后果变得重要。该项目的目标是更好地了解急性肺损伤患者及其家属长期心理症状和生活质量下降的风险因素，并为制定干预措施提供信息，以减少心理症状并改善急性肺损伤患者及其家属的生活质量。 (End摘要）