Molecular Surgeon Research Training on Vascular Disease

分子外科医生血管疾病研究培训

• 批准号: 8316269
• 负责人: Changyi Chen
• 金额: $ 13.24万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2015-04-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8316269
• 关键词: Molecular; Research Training; Surgeon; Vascular Diseases

Description (provided by applicant): In recent years, the vascular research programs within the Michael E. DeBakey Department of Surgery at the Baylor College of Medicine have been transformed to a high standard, producing great achievements and a great reputation. The program has attracted more and more medical students and surgical residents who are interested in a surgical research/academic career. The ultimate goal of the proposed T32 program, entitled "Molecular Surgeon Research Training on Vascular Disease," is to enhance the professional development and research capabilities of r surgical residents or fellows with a specific interest in academic careers as future vascular surgeon-scientists. This program will provide a multidisciplinary training for surgical residents or fellows for 2 years in 4 areas of opportunity within a broader field of vascular disease research including: 1) Tissue engineering and vascular imaging; 2) HIV related vascular complications; 3) Vascular injury and remodeling; and 4) Angiogenesis and vascular cell differentiation. These areas represent the strength of our training faculty and resources, clinical relevance, innovation of sciences, and uniqueness of program. There are 17 members of the program faculty from the Department of Surgery (6), Department of Medicine (4), Department of Pediatrics (2),Department of Bioengineering (2),Department of Otolaryngology-Head and Neck Surgery (1),Department of Molecular Virology and Microbiology (1),and Molecular Physiology and Biophysics (1). Each training area includes at least four faculty members. At least one faculty member in each training area comes from the Department of Surgery. All faculty members have NIH grant support in the relevant areas of research as well as have training experience. This five-year training grant will support 2 surgical residents or fellows per year, plus supplies, course work and travel allowances. Selection of the trainees will be based on candidates' demonstrated potential, ability and career choice of academic surgery. Trainees carry out their own projects under the guidance of their mentors' selected from the program faculty based on the background and research interest of the individual trainee. In addition, each trainee will participate in a core curriculum on biostatistics, ethical issues in research, scientific integrity, manuscript and grant preparation, and laboratory safety; workshops that provide in-depth training in each of the major investigative areas; research seminars; research conferences; and elective course work keyed to each trainee's research area. Trainees are not involved in any clinical activities unless research related. Extensive resources and core facilities are available for trainees, and special efforts are made to attract candidates from underrepresented minorities. The program is conducted and closely supervised by the program director (Dr. Johnny Chen), co-director (Dr. Alan B. Lumsden), operating committee, and advisory committee. At the completion of the program, surgical residents or fellows will be strongly prepared for academic positions from which they will launch their investigative careers in vascular surgery. Thus, this training program represents an effort at the Baylor College of Medicine to reverse the current national decline trend in the number of surgical residents and surgeons/physicians who are entering into academic research oriented careers.

描述（申请人提供）：近年来，贝勒医学院Michael E. DeBakey外科的血管研究项目已向高水平转型，取得了丰硕的成果和良好的声誉。该计划吸引了越来越多对外科研究/学术生涯感兴趣的医学生和外科住院医生。拟议的 T32 计划题为“血管疾病分子外科医生研究培训”，其最终目标是提高外科住院医生或对学术职业有特定兴趣的研究员作为未来血管外科医生科学家的专业发展和研究能力。 该计划将为外科住院医师或研究员提供为期 2 年的多学科培训，涉及更广泛的血管疾病研究领域的 4 个领域，包括： 1) 组织工程和血管成像； 2）HIV相关血管并发症； 3）血管损伤与重塑； 4) 血管生成和血管细胞分化。这些领域代表了我们培训师资和资源的实力、临床相关性、科学创新和项目的独特性。现有专任教师17人，分别为外科（6人）、医学部（4人）、儿科（2人）、生物工程系（2人）、耳鼻咽喉头颈外科（1人）、分子病毒与微生物学（1人）、分子生理与生物物理学（1人）。每个培训领域至少包括四名教职人员。每个培训领域至少有一名教员来自外科系。所有教员均获得美国国立卫生研究院 (NIH) 相关研究领域的资助支持，并拥有培训经验。 这笔为期五年的培训补助金每年将支持 2 名外科住院医生或研究员，外加用品、课程作业和旅行津贴。实习生的选择将根据候选人所表现出的潜力、能力和学术外科的职业选择而定。学员在导师的指导下开展自己的项目，导师是根据学员的背景和研究兴趣从项目教师中选出的。此外，每位学员将参加生物统计学、研究伦理问题、科学诚信、手稿和资助准备以及实验室安全等核心课程；为每个主要调查领域提供深入培训的讲习班；研究研讨会；研究会议；以及针对每个学员研究领域的选修课程。除非与研究相关，否则学员不参与任何临床活动。为学员提供广泛的资源和核心设施，并特别努力吸引来自代表性不足的少数族裔的候选人。该项目由项目主任（Johnny Chen 博士）、联合主任（Alan B. Lumsden 博士）、运营委员会和咨询委员会负责实施和密切监督。 该计划完成后，外科住院医师或研究员将为担任学术职位做好充分准备，并从此开始他们在血管外科领域的研究生涯。因此，该培训计划代表了贝勒医学院为扭转目前全国进入学术研究型职业的外科住院医师和外科医生/医师数量下降趋势而做出的努力。

项目成果

Arterial baroreceptors in the management of systemic hypertension.

• 发表时间: 2010
• 期刊: Medical science monitor : international medical journal of experimental and clinical research
• 作者: P. Kougias;Sarah M. Weakley;Q. Yao;P. Lin;Changyi J. Chen

Natural antioxidant dihydroxybenzyl alcohol blocks ritonavir-induced endothelial dysfunction in porcine pulmonary arteries and human endothelial cells.

天然抗氧化剂二羟基苯甲醇可阻断利托那韦诱导的猪肺动脉和人内皮细胞内皮功能障碍。

• DOI: 10.12659/msm.881926
• 发表时间: 2011
• 期刊: Medical science monitor : international medical journal of experimental and clinical research
• 作者: Weakley,SarahM;Jiang,Jun;Lü,Jianming;Wang,Xinwen;Lin,PeterH;Yao,Qizhi;Chen,Changyi
• 通讯作者: Chen,Changyi

Nordihydroguaiaretic acid (NDGA) inhibits ritonavir-induced endothelial dysfunction in porcine pulmonary arteries.

• DOI: 10.12659/msm.882040
• 发表时间: 2011-11
• 期刊: Medical science monitor : international medical journal of experimental and clinical research
• 作者: Lü JM;Nurko J;Jiang J;Weakley SM;Lin PH;Yao Q;Chen C
• 通讯作者: Chen C

Ginkgolide A-gold nanoparticles inhibit vascular smooth muscle proliferation and migration in vitro and reduce neointimal hyperplasia in a mouse model.

银杏内酯 A-金纳米粒子在体外抑制血管平滑肌增殖和迁移，并减少小鼠模型中的新生内膜增生。

• DOI: 10.1016/j.jss.2011.03.018
• 发表时间: 2011
• 期刊: The Journal of surgical research
• 作者: Weakley,SarahM;Wang,Xinwen;Mu,Hong;Lü,Jianming;Lin,PeterH;Yao,Qizhi;Chen,Changyi
• 通讯作者: Chen,Changyi

Anti-human protein S antibody induces tissue factor expression through a direct interaction with platelet phosphofructokinase.

抗人蛋白 S 抗体通过与血小板磷酸果糖激酶直接相互作用诱导组织因子表达。

• DOI: 10.1016/j.thromres.2013.11.009
• 发表时间: 2014
• 期刊: Thrombosis research
• 影响因子: 7.5
• 作者: Chen,Changyi;Liao,Dan;Wang,Jing;Liang,Zhengdong;Yao,Qizhi
• 通讯作者: Yao,Qizhi