Molecular Surgeon Research Training on Vascular Disease

描述（申请人提供）：近年来，Michael E.贝勒医学院的DeBakey外科已经转变为高标准，取得了巨大的成就和声誉。该计划吸引了越来越多的医学生和外科住院医生，他们对外科研究/学术生涯感兴趣。拟议的T32计划的最终目标，题为“血管疾病的分子外科医生研究培训”，是为了提高专业发展和研究能力的r外科住院医生或研究员的学术生涯作为未来的血管外科医生，科学家的具体利益。 该计划将为外科住院医生或研究员提供为期2年的多学科培训，在血管疾病研究的更广泛领域内的4个机会领域，包括：1）组织工程和血管成像; 2）HIV相关的血管并发症; 3）血管损伤和重塑;和4）血管生成和血管细胞分化。这些领域代表了我们培训教师和资源的优势，临床相关性，科学创新和计划的独特性。有17名来自外科（6），内科（4），儿科（2），生物工程（2），耳鼻咽喉头颈外科（1），分子病毒学和微生物学（1）和分子生理学和生物物理学（1）部门的计划教师。每个培训区至少包括四名教师。每个培训领域至少有一名教员来自外科。所有教职员工都在相关研究领域获得NIH资助，并有培训经验。 这项为期五年的培训补助金每年将支持2名外科住院医生或研究员，外加用品、课程工作和旅行津贴。学员的选择将基于候选人表现出的潜力，能力和学术外科的职业选择。学员在导师的指导下开展自己的项目，导师是根据学员个人的背景和研究兴趣从项目教师中挑选出来的。此外，每个受训人员将参加关于生物统计、研究中的道德问题、科学诚信、手稿和赠款准备以及实验室安全的核心课程;在每个主要调查领域提供深入培训的讲习班;研究研讨会;研究会议;以及与每个受训人员的研究领域相关的选修课。受训人员不参与任何临床活动，除非与研究相关。为受训人员提供了广泛的资源和核心设施，并作出特别努力吸引代表性不足的少数群体的候选人。该项目由项目主任（陈强尼博士）、联合主任（艾伦B博士）和项目主任（陈博士）密切监督。拉姆斯登）、运营委员会和咨询委员会。 在该计划完成后，外科住院医生或研究员将为学术职位做好充分准备，他们将在血管外科开展他们的调查职业生涯。因此，该培训计划代表了贝勒医学院的努力，以扭转目前全国外科住院医师和外科医生/医生人数下降的趋势，他们正在进入学术研究导向的职业生涯。

Description (provided by applicant): In recent years, the vascular research programs within the Michael E. DeBakey Department of Surgery at the Baylor College of Medicine have been transformed to a high standard, producing great achievements and a great reputation. The program has attracted more and more medical students and surgical residents who are interested in a surgical research/academic career. The ultimate goal of the proposed T32 program, entitled "Molecular Surgeon Research Training on Vascular Disease," is to enhance the professional development and research capabilities of r surgical residents or fellows with a specific interest in academic careers as future vascular surgeon-scientists. This program will provide a multidisciplinary training for surgical residents or fellows for 2 years in 4 areas of opportunity within a broader field of vascular disease research including: 1) Tissue engineering and vascular imaging; 2) HIV related vascular complications; 3) Vascular injury and remodeling; and 4) Angiogenesis and vascular cell differentiation. These areas represent the strength of our training faculty and resources, clinical relevance, innovation of sciences, and uniqueness of program. There are 17 members of the program faculty from the Department of Surgery (6), Department of Medicine (4), Department of Pediatrics (2),Department of Bioengineering (2),Department of Otolaryngology-Head and Neck Surgery (1),Department of Molecular Virology and Microbiology (1),and Molecular Physiology and Biophysics (1). Each training area includes at least four faculty members. At least one faculty member in each training area comes from the Department of Surgery. All faculty members have NIH grant support in the relevant areas of research as well as have training experience. This five-year training grant will support 2 surgical residents or fellows per year, plus supplies, course work and travel allowances. Selection of the trainees will be based on candidates' demonstrated potential, ability and career choice of academic surgery. Trainees carry out their own projects under the guidance of their mentors' selected from the program faculty based on the background and research interest of the individual trainee. In addition, each trainee will participate in a core curriculum on biostatistics, ethical issues in research, scientific integrity, manuscript and grant preparation, and laboratory safety; workshops that provide in-depth training in each of the major investigative areas; research seminars; research conferences; and elective course work keyed to each trainee's research area. Trainees are not involved in any clinical activities unless research related. Extensive resources and core facilities are available for trainees, and special efforts are made to attract candidates from underrepresented minorities. The program is conducted and closely supervised by the program director (Dr. Johnny Chen), co-director (Dr. Alan B. Lumsden), operating committee, and advisory committee. At the completion of the program, surgical residents or fellows will be strongly prepared for academic positions from which they will launch their investigative careers in vascular surgery. Thus, this training program represents an effort at the Baylor College of Medicine to reverse the current national decline trend in the number of surgical residents and surgeons/physicians who are entering into academic research oriented careers.