Molecular Surgeon Research Training on Vascular Disease

描述（由申请人提供）：近年来，贝勒医学院Michael E. DeBakey外科血管研究项目已经向高水平转变，取得了巨大的成就和声誉。该项目吸引了越来越多对外科研究/学术生涯感兴趣的医学生和外科住院医师。T32计划的最终目标是“血管疾病分子外科医生研究培训”，旨在提高外科住院医师或对未来血管外科科学家的学术生涯有特殊兴趣的研究员的专业发展和研究能力。该项目将为外科住院医师或研究员提供为期2年的多学科培训，涉及4个更广泛的血管疾病研究领域，包括：1)组织工程和血管成像；2) HIV相关血管并发症；3)血管损伤与重塑；4)血管生成和血管细胞分化。这些领域代表了我们的培训师资力量和资源、临床相关性、科学创新和项目的独特性。现有教职工17人，分别来自外科（6人）、内科（4人）、儿科（2人）、生物工程系（2人）、耳鼻喉头颈外科（1人）、分子病毒学与微生物学（1人）、分子生理与生物物理（1人）。每个培训区域至少包括四名教员。每个培训领域至少有一名教员来自外科。所有教师都在相关研究领域获得NIH的资助，并具有培训经验。这项为期五年的培训补助金每年将支持2名外科住院医师或研究员，加上用品，课程和旅行津贴。学员的选择将根据候选人的表现潜力、能力和学术外科的职业选择。学员在导师的指导下开展自己的项目，导师根据学员个人的背景和研究兴趣从项目教师中挑选。此外，每位受训者将参加有关生物统计学、研究伦理问题、科学诚信、稿件和拨款准备以及实验室安全的核心课程；在每个主要调查领域提供深入培训的讲习班；研究研讨会;研究会议;选修课程与每个学员的研究领域密切相关。除非与研究有关，受训者不得参与任何临床活动。为受训者提供了广泛的资源和核心设施，并作出特别努力吸引代表性不足的少数民族的候选人。该项目由项目主任（Johnny Chen博士）、联合主任（Alan B. Lumsden博士）、运营委员会和咨询委员会密切监督。在课程完成后，外科住院医师或研究员将为学术职位做好充分的准备，从而开始他们在血管外科的研究生涯。因此，这个培训项目代表了贝勒医学院的一项努力，以扭转目前全国外科住院医师和外科医生/内科医生进入学术研究导向职业的数量下降的趋势。

Description (provided by applicant): In recent years, the vascular research programs within the Michael E. DeBakey Department of Surgery at the Baylor College of Medicine have been transformed to a high standard, producing great achievements and a great reputation. The program has attracted more and more medical students and surgical residents who are interested in a surgical research/academic career. The ultimate goal of the proposed T32 program, entitled "Molecular Surgeon Research Training on Vascular Disease," is to enhance the professional development and research capabilities of r surgical residents or fellows with a specific interest in academic careers as future vascular surgeon-scientists. This program will provide a multidisciplinary training for surgical residents or fellows for 2 years in 4 areas of opportunity within a broader field of vascular disease research including: 1) Tissue engineering and vascular imaging; 2) HIV related vascular complications; 3) Vascular injury and remodeling; and 4) Angiogenesis and vascular cell differentiation. These areas represent the strength of our training faculty and resources, clinical relevance, innovation of sciences, and uniqueness of program. There are 17 members of the program faculty from the Department of Surgery (6), Department of Medicine (4), Department of Pediatrics (2),Department of Bioengineering (2),Department of Otolaryngology-Head and Neck Surgery (1),Department of Molecular Virology and Microbiology (1),and Molecular Physiology and Biophysics (1). Each training area includes at least four faculty members. At least one faculty member in each training area comes from the Department of Surgery. All faculty members have NIH grant support in the relevant areas of research as well as have training experience. This five-year training grant will support 2 surgical residents or fellows per year, plus supplies, course work and travel allowances. Selection of the trainees will be based on candidates' demonstrated potential, ability and career choice of academic surgery. Trainees carry out their own projects under the guidance of their mentors' selected from the program faculty based on the background and research interest of the individual trainee. In addition, each trainee will participate in a core curriculum on biostatistics, ethical issues in research, scientific integrity, manuscript and grant preparation, and laboratory safety; workshops that provide in-depth training in each of the major investigative areas; research seminars; research conferences; and elective course work keyed to each trainee's research area. Trainees are not involved in any clinical activities unless research related. Extensive resources and core facilities are available for trainees, and special efforts are made to attract candidates from underrepresented minorities. The program is conducted and closely supervised by the program director (Dr. Johnny Chen), co-director (Dr. Alan B. Lumsden), operating committee, and advisory committee. At the completion of the program, surgical residents or fellows will be strongly prepared for academic positions from which they will launch their investigative careers in vascular surgery. Thus, this training program represents an effort at the Baylor College of Medicine to reverse the current national decline trend in the number of surgical residents and surgeons/physicians who are entering into academic research oriented careers.