Oncology Research Training for Surgeon-Scientists

项目摘要 本申请是外科医生科学家转化肿瘤学研究培训的竞争性更新， 肯塔基州（英国）大学的一项变革性培训计划，专为 外科学科和肿瘤学研究的兴趣。该计划解决了关键的国家 在两年的时间里，从事癌症研究的外科医生科学家人数下降， 强化的跨学科指导研究培训，使受训者成为独立的科学家 他们准备好将在培训期间学到的最先进的技术融入到一个 成功的学术研究生涯。学员（每年2名）通常在以下时间进入该计划 完成研究生年（PGY）2或3的住院医师培训或完成手术后， 住院医生，并选择基础科学选项（轨道1）或医疗保健提供研究选项 （第二轨道）。途径1的机会涵盖细胞信号传导、肿瘤生物学、癌症进展和转移， 以及代谢组学、癌基因组学和表观遗传学等不断发展的领域。轨道2，拟议的新方案 该方案的组成部分是提供关于癌症差异、实施科学和人口一级调查的培训。在 除了密集的研究经验，学员完成科学硕士或博士学位的临床 和翻译科学，并补充他们的课程与进一步发展，通过结合 举办正规课程和专业技能发展讲习班和研讨会， 开展研究、复制性以及手稿和提案编制。通过定期 研讨会和讲座可通过马基癌症中心，他们的部门和著名的英国 中心，包括临床和转化科学中心，学员从事丰富的经验， 教学式学习，使他们成为多学科团队的积极贡献者， 对于复杂癌症患者的最佳治疗至关重要。成功完成的要求 无论是硕士或博士学位增加了深度和广度，这一培训计划，扩大接触， 其他在论文委员会任职的英国科学家。初级培训学院由基础和 人口科学家和临床科学家，他们都在跨学科合作;每个主要 教师导师是他或她的领域公认的专家，并在研究生产力的长期记录， 培训年轻的调查员。“管道”导师发展机制使我们能够发展有前途的 在我们的团队为基础的指导方法作为导师的早期职业教师。这个项目， 致力于促进外科医生科学家社区的多样性，包括妇女和来自 代表性不足的群体，在实现其目标，解决令人震惊的下降， 进行肿瘤学研究的活跃外科医生科学家的数量。作为一个培训机构，我们 充满激情，积极主动，致力于培养未来的学术外科医生。

PROJECT SUMMARY This application is a competitive renewal of Translational Oncology Research Training for Surgeon Scientists, a transformative training program at the University of Kentucky (UK) designed for qualified trainees in the surgical disciplines and with an interest in oncology research. The program addresses critical national declines in the number of surgeon scientists engaged in cancer research through a two-year period of intensive, interdisciplinary mentored research training to prepare trainees to become independent scientists who are well prepared to incorporate state-of-the-art techniques learned during their training period into a successful academic research career. Trainees (2 each year) typically enter the program following completion of postgraduate year (PGY) 2 or 3 of their residency training or upon completion of the surgical residency and select either the basic science option (Track 1) or the healthcare delivery research option (Track 2). Opportunities in Track 1 span cell signaling, tumor biology, cancer progression and metastasis as well as evolving areas such metabolomics, oncogenomics and epigenetics. Track 2, a proposed new program component, provides training in cancer disparities, implementation science and population-level enquiry. In addition to an intensive research experience, trainees complete a Master of Science or PhD degree in clinical and translational sciences and supplement their coursework with further development through a combination of formal courses and professional skills development workshops and seminars in such areas as responsible conduct of research, reproducibility and manuscript and proposal development. Through regularly scheduled seminars and lectures available through the Markey Cancer Center, their departments and prominent UK centers, including the Center for Clinical and Translational Science, trainees engage in rich experiential and didactic learning that prepares them as active contributors to the types of multidisciplinary teams that are essential for the optimal treatment of the complex cancer patient. The requirement to successfully complete either a master’s or PhD degree adds depth and breadth to this program of training, broadening exposure to other UK scientists serving on thesis committees. The primary training faculty is composed of basic and population scientists and clinician-scientists, all of whom work collaboratively across disciplines; each primary faculty mentor is a recognized expert in his or her field and has a long record of research productivity in the training of young investigators. A “pipeline” mentor development mechanism allows us to develop promising early-career faculty members as mentors within our team-based mentoring approach. This program, which is committed to fostering diversity in the community of surgeon scientists, including women and those from underrepresented groups, has been highly successful in achieving its goals to address alarming declines in the number of active surgeon-scientists conducting oncology research. As a training faculty, we are passionate, motivated and committed to the training of future academic surgeons.