Growth Factors in Recurrent Aphthous Stomatitis
复发性口疮性口炎中的生长因子
基本信息
- 批准号:8509080
- 负责人:
- 金额:$ 1.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-07-01 至 2012-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): Recurrent Aphthous Stomatitis (RAS) is a very common ulcerative oral mucosal disease of unknown etiology. The lack of understanding of the exact etiology and mechanism of ulcer formation in patients afflicted by this very painful condition has hampered the development of effective therapies. In order to plan and implement successful clinical trials leading to the development of better drugs for our patients we must first identify the cause of this disease. Most scientists agree that the immune system is activated in RAS. However, there is no agreement as to what leads to its activation and ultimately to the development of RAS. Modern medicine has identified intense cross-talks between the endocrine and immune system. In particular, growth factors, such as IGF-1 and leptin, have been shown to regulate the immune system and also wound healing. In two separate published population studies we have found a striking overlap in the distributions with age in RAS prevalence and these growth factors. These data, however, do not directly associate RAS and serum levels of growth factors within a single sample population. Our overall hypothesis is that an up-regulation of the IGF-1/leptin pathway is the primary source of immune activation and impaired wound healing in RAS patients. We propose a detailed person-level study of these factors through secondary statistical analyses of nationally representative data. Specific Aim 1 is to compare serum IGF-1 levels in individuals with and without RAS upon examination. Specific Aim 2 is to compare serum leptin levels in individuals with and without RAS upon examination. We expect higher IGF-1 and leptin levels in patients with active RAS vs. controls. These results will provide the first evidence that the levels of these growth factors are closely associated with the presence of painful ulcers. The results of these analyses will create the foundation for R01-level clinical research studies focused on the IGF-1/leptin pathway as the primary driving force leading to RAS formation.
PUBLIC HEALTH RELEVANCE: Recurrent Aphthous Stomatitis (RAS; also known as canker sores) is a very common and painful disease of unknown cause that occurs primarily during growth. We have noted a remarkable overlap between RAS and certain growth factors that regulate wound healing, suggesting that this could be the pathway through which RAS develops. The identification of the specific mechanism that leads to RAS formation would open the door to the development of more targeted drugs, expected to have fewer side effects and greater efficacy, for patients suffering from this condition.
描述(由申请人提供):复发性阿弗他口炎(RAS)是一种非常常见的病因不明的溃疡性口腔粘膜疾病。由于缺乏对这种非常痛苦的疾病患者溃疡形成的确切病因学和机制的了解,阻碍了有效治疗方法的发展。为了计划和实施成功的临床试验,为我们的患者开发更好的药物,我们必须首先确定这种疾病的原因。大多数科学家同意,免疫系统在RAS中被激活。然而,对于是什么导致其激活并最终导致RAS的发展,还没有达成一致。现代医学已经确定了内分泌系统和免疫系统之间的强烈交互作用。特别是,生长因子,如IGF-1和瘦素,已被证明可以调节免疫系统和伤口愈合。在两项独立发表的人群研究中,我们发现RAS患病率和这些生长因子的年龄分布有惊人的重叠。然而,这些数据并不直接关联RAS和血清生长因子水平在一个单一的样本人群。我们的总体假设是,IGF-1/瘦素途径的上调是RAS患者免疫激活和伤口愈合受损的主要来源。我们建议通过对全国代表性数据的二次统计分析,对这些因素进行详细的个人层面研究。具体目的1是比较检查时有和没有RAS的个体的血清IGF-1水平。具体目标2是比较检查时有和没有RAS的个体的血清瘦素水平。我们预计活动性RAS患者的IGF-1和瘦素水平高于对照组。这些结果将首次证明这些生长因子的水平与疼痛性溃疡的存在密切相关。这些分析的结果将为R 01水平的临床研究奠定基础,研究重点是IGF-1/瘦素途径作为导致RAS形成的主要驱动力。
公共卫生关系:复发性口疮(RAS;也称为口腔溃疡)是一种非常常见的疼痛性疾病,原因不明,主要发生在生长期间。我们已经注意到RAS和某些调节伤口愈合的生长因子之间存在显著的重叠,这表明这可能是RAS发展的途径。确定导致RAS形成的特定机制将为开发更有针对性的药物打开大门,预计这些药物对患有这种疾病的患者具有更少的副作用和更大的疗效。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Lorena Baccaglini其他文献
Lorena Baccaglini的其他文献
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{{ truncateString('Lorena Baccaglini', 18)}}的其他基金
Growth Factors in Recurrent Aphthous Stomatitis
复发性口疮性口炎中的生长因子
- 批准号:
7990993 - 财政年份:2010
- 资助金额:
$ 1.41万 - 项目类别:
Molecular Epidemiology of Recurrent Aphthous Stomatitis: Role of Ghrelin
复发性口疮性口炎的分子流行病学:Ghrelin 的作用
- 批准号:
7684223 - 财政年份:2008
- 资助金额:
$ 1.41万 - 项目类别:
Molecular Epidemiology of Recurrent Aphthous Stomatitis: Role of Ghrelin
复发性口疮性口炎的分子流行病学:Ghrelin 的作用
- 批准号:
7531338 - 财政年份:2008
- 资助金额:
$ 1.41万 - 项目类别:
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Growth Factors in Recurrent Aphthous Stomatitis
复发性口疮性口炎中的生长因子
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