Epidemiology of Recurrent Aphthous Stomatitis

复发性口疮性口炎的流行病学

• 批准号: 7234121
• 负责人: Lorena Baccaglini
• 金额: $ 7.06万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7234121
• 关键词: Accounting; Affect; Antisense Oligonucleotides; Aphthous Stomatitis; Biopsy; Blood; Case-Control Studies; Clinical; Condition; DNA; DNA Databases; Data; Data Collection; Databases; Demographic Analyses; Development; Disease; Economics; Environmental Risk Factor; Epidemiologic Studies; Epidemiology; Ethnic group; Etiology; Foundations; Future; Gene Expression; Gene Expression Profile; Genes; Genetic; Inflammatory; Knowledge; Laboratories; Lead; Life; Matrix Metalloproteinase Inhibitor; Matrix Metalloproteinases; Methods; Mexican Americans; Mouth Diseases; North America; Oral Ulcer; Oral mucous membrane structure; Outcome; Pain; Pathogenesis; Patients; Peptides; Pilot Projects; Play; Population; Prevalence; Procedures; Process; Public Health; Quality of life; Questionnaires; Recording of previous events; Recurrence; Reporting; Research; Resources; Risk Factors; Role; Sampling; Series; Shipping; Ships; Somatostatin; South Texas; Specimen; Surveys; Thinking; Tissues; Ulcer; United States; aged; base; cytokine; experience; genetic risk factor; human tissue; improved; inhibitor/antagonist; interdisciplinary approach

DESCRIPTION (provided by applicant): Background: Recurrent aphthous stomatitis (RAS) is the most common inflammatory ulcerative disease of the oral cavity in the United States. The etiopathogenesis of RAS is unknown. Genetic and environmental risk factors are thought to play a role. Our preliminary analyses of the demographic distribution of RAS indicate that the prevalence of this condition is higher in Mexican-Americans. However, no detailed analyses have been conducted thus far on genetic and environmental risk factors for RAS in this population. Methods: We will conduct a case-control study to collect epidemiologic data through questionnaires and clinical examinations to determine risk factors for RAS in a South Texas population with a large Mexican-American ethnic group (Specific Aim #1). We will conduct a pilot study of gene expression in RAS and control tissue to gather preliminary data on the role of matrix metalloproteinases (MMPs), their inhibitors (i.e., tissue inhibitors of MMPs and somatostatin), and MMP-related cytokines in the pathogenesis of RAS (Specific Aim #2). Lastly, we will bank data and DNA collected through questionnaires, examinations, blood drawing, and gene expression analyses of biopsy tissue to facilitate future genetic epidemiologic studies of RAS (Specific Aim #3). Outcome/Benefit: This is the first study of a series of genetic epidemiologic studies of RAS. The case- control study will provide important information on the role of environmental, socio-economic, and host- related risk factors for RAS. The pilot study will provide new preliminary data on the role of MMPs, their inhibitors, MMP-related cytokines, and other genes in the pathogenesis of RAS. Collectively, the results of this research and the banked data will constitute an important foundation for future epidemiologic studies aimed at understanding the combined role of environmental and genetic risk factors for RAS. Relevance to Public Health: This study is aimed at understanding the cause of painful recurrent mouth ulcers (canker sores), which is unknown. Understanding the cause of canker sores can lead to better treatments for patients affected by this condition.

描述（由申请人提供）：背景：复发性阿弗他口炎（RAS）是美国最常见的口腔炎性溃疡性疾病。RAS的发病机制尚不清楚。遗传和环境风险因素被认为发挥了作用。我们对RAS的人口学分布的初步分析表明，这种情况在墨西哥裔美国人中的患病率较高。然而，迄今为止，尚未对该人群中RAS的遗传和环境风险因素进行详细分析。研究方法：我们将进行一项病例对照研究，通过问卷调查和临床检查收集流行病学数据，以确定南德克萨斯州大型墨西哥裔美国人人群中RAS的风险因素（具体目标#1）。我们将对RAS和对照组织中的基因表达进行初步研究，以收集关于基质金属蛋白酶（MMP）及其抑制剂（即，MMPs和生长抑素的组织抑制剂），以及RAS发病机制中的MMP相关细胞因子（具体目标#2）。最后，我们将通过问卷调查、检查、抽血和活检组织的基因表达分析收集数据和DNA，以促进未来RAS的遗传流行病学研究（具体目标#3）。结果/获益：这是RAS遗传流行病学系列研究中的第一项研究。病例对照研究将为RAS的环境、社会经济和宿主相关风险因素的作用提供重要信息。初步研究将提供新的初步数据的作用，基质金属蛋白酶，其抑制剂，基质金属蛋白酶相关的细胞因子，和其他基因在RAS的发病机制。总的来说，这项研究的结果和库存数据将构成未来流行病学研究的重要基础，旨在了解环境和遗传风险因素对RAS的综合作用。与公共卫生的相关性：本研究旨在了解疼痛性复发性口腔溃疡（口腔溃疡）的原因，这是未知的。了解口腔溃疡的原因可以为受这种情况影响的患者提供更好的治疗。