EPIDEMIOLOGY OF RECURRENT APHTHOUS STOMATITIS

复发性口疮性口腔炎的流行病学

• 批准号: 7605511
• 负责人: Lorena Baccaglini
• 金额: $ 3.7万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-23 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605511
• 关键词: Aphthous Stomatitis; Biopsy; Blood; Case-Control Studies; Clinical; Computer Retrieval of Information on Scientific Projects Database; DNA Databases; Data; Databases; Development; Disease; Economics; Environmental Risk Factor; Epidemiologic Studies; Epidemiology; Foundations; Funding; Future; Gene Expression; Genes; Genetic; Grant; Inflammatory; Institution; Matrix Metalloproteinase Inhibitor; Matrix Metalloproteinases; Methods; Mouth Diseases; Outcome; Pathogenesis; Pilot Projects; Play; Questionnaires; Recurrence; Research; Research Personnel; Resources; Risk Factors; Role; Series; Somatostatin; Source; Thinking; Tissues; United States; United States National Institutes of Health; cytokine; genetic risk factor; inhibitor/antagonist

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recurrent aphthous stomatitis (RAS) is the most common inflammatory ulcerative disease of the oral cavity in the United States. Genetic and environmental risk factors are thought to play a role in the development of RAS. However, the etiopathogenesis of this disease is still unknown. Methods: We will conduct a case-control study to collect epidemiologic data through questionnaires and clinical examinations to determine risk factors for RAS (Specific Aim #1). We will conduct a pilot study of gene expression in RAS and control tissue to gather preliminary data on the role of matrix metalloproteinases (MMPs), their inhibitors (i.e., tissue inhibitors of MMPs and somatostatin), and MMP-related cytokines in the pathogenesis of RAS (Specific Aim #2). Lastly, we will bank data and DNA collected through questionnaires, examinations, blood drawing, and gene expression analyses of biopsy tissue to facilitate future genetic epidemiologic studies of RAS (Specific Aim #3). Outcome/Benefit: This is the first study of a series of genetic epidemiologic studies of RAS. The case-control study will provide important information on the role of environmental, socio-economic, and host-related risk factors for RAS. The pilot study will provide new preliminary data on the role of MMPs, their inhibitors, MMP-related cytokines, and other genes in the pathogenesis of RAS. Collectively, the results of this research and the banked data will constitute an important foundation for future epidemiologic studies aimed at understanding the combined role of environmental and genetic risk factors for RAS.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 复发性阿弗他口炎 (RAS) 是美国最常见的口腔炎症溃疡性疾病。遗传和环境风险因素被认为在 RAS 的发展中发挥着作用。然而，这种疾病的发病机制仍不清楚。方法：我们将进行病例对照研究，通过问卷调查和临床检查收集流行病学数据，以确定 RAS 的危险因素（具体目标#1）。 我们将对 RAS 和对照组织中的基因表达进行初步研究，以收集有关基质金属蛋白酶 (MMP)、其抑制剂（即 MMP 和生长抑素的组织抑制剂）以及 MMP 相关细胞因子在 RAS 发病机制中的作用的初步数据（具体目标 #2）。 最后，我们将通过问卷调查、检查、抽血和活检组织的基因表达分析收集数据和 DNA，以促进未来 RAS 的遗传流行病学研究（具体目标#3）。结果/益处：这是一系列 RAS 遗传流行病学研究中的第一项研究。病例对照研究将为 RAS 的环境、社会经济和宿主相关风险因素的作用提供重要信息。该试点研究将为 MMP、其抑制剂、MMP 相关细胞因子和其他基因在 RAS 发病机制中的作用提供新的初步数据。总的来说，这项研究的结果和储存的数据将为未来的流行病学研究奠定重要基础，旨在了解环境和遗传风险因素对 RAS 的综合作用。