UW SMPH CSC L3 unit rodent containment and quarantine

描述（由申请人提供）：威斯康星大学麦迪逊分校目前缺乏足够规模的功能性隔离空间来容纳其啮齿动物种群。华盛顿大学小鼠和大鼠的平均每日普查数量分别为85,340只和17,231只。华盛顿大学最近完成了一个34,500平方英尺的建筑。威斯康星医学研究所（WIMR）的啮齿动物设施。目前安置在邻近临床科学中心（CSC）的啮齿动物将在胚胎或剖宫产再移植成功后转移到WIMR。此举将使华盛顿大学拥有一个较旧的动物设施，可以重新改造成一个急需的啮齿动物控制和隔离区。翻新后的设施将成为西澳大学校园的核心资源，将有超过337名研究人员使用，影响超过3.49亿美元的研究资金。对CSC空间的拟议变更包括购买：高密度啮齿动物住房架、生物安全柜、实验室/手术台、麻醉机、一些小的翻新和设施HVAC系统的现代化。翻新后的设施将有五个主要用途：(1)作为一个隔离区，用于任何在特定的无病原体设施中被啮齿动物病原体污染的啮齿动物群体。(2)允许研究人员在设施占地范围内的空间，在新装备的手术室进行啮齿动物操作。(3)在产生与再衍生程序相关的成本和时间延迟之前，为试点研究创造空间。(4)允许华盛顿大学灵活地从非再生来源获取有价值的啮齿动物品系进行试点研究。(5)最后，部分翻新空间将成为专门的啮齿动物隔离区，用于检测和处理来自未经批准的供应商的啮齿动物品种。威斯康星大学麦迪逊分校临床科学中心动物设施的相关改造将为整个校园提供更好、更有效的啮齿动物饲养实践。这一项目将为我们的研究工作创造更好的环境，从而进一步研究人类疾病和开发创新疗法，从而对公众健康产生直接和持续的影响。

DESCRIPTION (provided by applicant): The University of Wisconsin-Madison campus currently lacks a functional containment and quarantine space of sufficient size to accommodate its rodent populations. The average daily census for mice and rats at the UW is 85,340 and 17,231 respectively. The UW recently completed the construction of a 34,500 sq. ft. rodent facility in the Wisconsin Institutes for Medical Research (WIMR). Rodents currently housed in the adjacent Clinical Sciences Center (CSC) will be moved into WIMR following successful embryo or cesarean rederivation. This move will leave the UW with an older animal facility that can be repurposed into a much needed rodent containment and quarantine area. The refurbished facility will serve as a core resource on the UW campus and will be utilized by over 337 researchers impacting more than $349 million in research funds. The proposed changes to the CSC space include the purchase of: high-density rodent housing racks, bio- safety cabinets, laboratory/procedure tables, anesthesia machines, some minor renovation, and modernization of the facility's HVAC system. The renovated facility will have five main uses: (1) Serve as a containment area for any rodent colony in an specific pathogen free facility that becomes contaminated with a rodent pathogen. (2) Allow researchers space within the footprint of the facility for rodent manipulation in newly outfitted procedure rooms. (3) Create space for pilot studies prior to incurring cost and time delays associated with rederivation procedures. (4) Allow the UW flexibility in acquiring valuable rodent lines from non-rederived sources for pilot studies. (5) Finally, part of the refurbished space would become a dedicated rodent quarantine area for the testing and treatment of rodent lines from non-approved vendors. Relevance Renovation of the University of Wisconsin-Madison Clinical Sciences Center animal facility will allow for better and more efficient rodent husbandry practices for the whole campus. This project will have a direct and ongoing impact on public health, by creating a better environment for our research efforts, thus furthering the study of human diseases and enabling the development of innovative treatments.