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The effects of lung transplantation on lung disease related disabilities

肺移植对肺病相关残疾的影响

基本信息

批准号：
8057964
负责人：
Jonathan Paul Singer
金额：
$ 6.33万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-06-30 至 2012-06-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8057964
关键词：
Accounting Adult Affect Anxiety Area Blood Vessels Cohort Studies Comorbidity Data Diabetes Mellitus Disease Exercise Family health status Functional disorder General Population Health Personnel Hypertension Impairment Infection Intervention Kidney Failure Lead Life Lower Extremity Lung Lung Transplantation Lung diseases Measures Medical Records Mental Depression Myopathy Organ Osteoporosis Outcome Outcome Measure Patient-Focused Outcomes Patients Performance Pharmaceutical Preparations Pulmonary function tests Recurrence Residual state Respiratory physiology Role SF-12 Severity of illness Skeletal Muscle Sleeplessness Source Staging Structure Surveys Systemic disease Testing Theoretical model Therapeutic Intervention Transplant Recipients Transplantation Value of Life Walking cancer risk coping disability graft function health related quality of life improved muscle strength novel prospective

项目摘要

DESCRIPTION (provided by applicant): Health related quality of life (HRQL) is a key, patient-centered outcome in lung transplantation. While HRQL may improve following transplantation, available data indicate that HRQL remains well below that of the general population. In theoretical models of disablement, the domain of functional limitation leads to disability and both are precursors to and, therefore, "upstream" determinants of HRQL. To date, the determinants of HRQL and the role of persistent limitations and associated disability in the HRLQ limitations following transplant have not been elucidated. The central study hypotheses are that patients with end-stage lung disease will suffer from functional limitations, disability, and poor HRQL and that following transplantation, both pulmonary and non-pulmonary organ dysfunction, associated in part with therapies required to preserve graft function, will account for residual functional limitations, ongoing disability, and persistently reduced HRQL. A prospective cohort study is proposed to assess functional limitations, disability, and HRQL in patients with end-stage lung disease before and after lung transplantation. Prior to transplantation, subjects will complete a structured survey assessing functional limitations, disability, HRQL. In addition, tests of lung function, exercise capacity (6 minute walk test), and lower extremity strength will be performed. Supplemental data related to the disease indication for transplantation, disease severity and comorbidities will be extracted from medical records. Key measures will be repeated at 3, 6, and 12 months after lung transplantation. Baseline data will be used as follows: to elucidate the impact of end- stage lung disease on functional limitation, disability, and HRQL on patients awaiting lung transplantation. Longitudinal data will be used as follows: to assess the impact of lung transplantation on measures of functional limitation, disability, and HRQL and to identify sources of persistent or new limitations or disabilities that may affect HRQL. We intend to study 30 subjects using repeated measures analysis and allowing for sufficient study power to detect an 0.5 SD change (consistent with a clinically meaningful difference) in key outcome measures. PUBLIC HEALTH RELEVANCE: Characterizing how lung transplantation enables or does not assist patients with end-stage lung disease to return to participating in activities they rate as meaningful (valued life activities) should provide valuable information to patients, their families, and health care providers coping with post- transplantation management. Moreover, elucidating the causes of functional limitations and disability following transplant may identify new areas for intervention that may lead to improved outcomes, in particular HRQL.