The effects of lung transplantation on lung disease related disabilities
肺移植对肺病相关残疾的影响
基本信息
- 批准号:8057964
- 负责人:
- 金额:$ 6.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-06-30 至 2012-06-29
- 项目状态:已结题
- 来源:
- 关键词:AccountingAdultAffectAnxietyAreaBlood VesselsCohort StudiesComorbidityDataDiabetes MellitusDiseaseExerciseFamily health statusFunctional disorderGeneral PopulationHealth PersonnelHypertensionImpairmentInfectionInterventionKidney FailureLeadLifeLower ExtremityLungLung TransplantationLung diseasesMeasuresMedical RecordsMental DepressionMyopathyOrganOsteoporosisOutcomeOutcome MeasurePatient-Focused OutcomesPatientsPerformancePharmaceutical PreparationsPulmonary function testsRecurrenceResidual stateRespiratory physiologyRoleSF-12Severity of illnessSkeletal MuscleSleeplessnessSourceStagingStructureSurveysSystemic diseaseTestingTheoretical modelTherapeutic InterventionTransplant RecipientsTransplantationValue of LifeWalkingcancer riskcopingdisabilitygraft functionhealth related quality of lifeimprovedmuscle strengthnovelprospective
项目摘要
DESCRIPTION (provided by applicant): Health related quality of life (HRQL) is a key, patient-centered outcome in lung transplantation. While HRQL may improve following transplantation, available data indicate that HRQL remains well below that of the general population. In theoretical models of disablement, the domain of functional limitation leads to disability and both are precursors to and, therefore, "upstream" determinants of HRQL. To date, the determinants of HRQL and the role of persistent limitations and associated disability in the HRLQ limitations following transplant have not been elucidated. The central study hypotheses are that patients with end-stage lung disease will suffer from functional limitations, disability, and poor HRQL and that following transplantation, both pulmonary and non-pulmonary organ dysfunction, associated in part with therapies required to preserve graft function, will account for residual functional limitations, ongoing disability, and persistently reduced HRQL. A prospective cohort study is proposed to assess functional limitations, disability, and HRQL in patients with end-stage lung disease before and after lung transplantation. Prior to transplantation, subjects will complete a structured survey assessing functional limitations, disability, HRQL. In addition, tests of lung function, exercise capacity (6 minute walk test), and lower extremity strength will be performed. Supplemental data related to the disease indication for transplantation, disease severity and comorbidities will be extracted from medical records. Key measures will be repeated at 3, 6, and 12 months after lung transplantation. Baseline data will be used as follows: to elucidate the impact of end- stage lung disease on functional limitation, disability, and HRQL on patients awaiting lung transplantation. Longitudinal data will be used as follows: to assess the impact of lung transplantation on measures of functional limitation, disability, and HRQL and to identify sources of persistent or new limitations or disabilities that may affect HRQL. We intend to study 30 subjects using repeated measures analysis and allowing for sufficient study power to detect an 0.5 SD change (consistent with a clinically meaningful difference) in key outcome measures.
PUBLIC HEALTH RELEVANCE: Characterizing how lung transplantation enables or does not assist patients with end-stage lung disease to return to participating in activities they rate as meaningful (valued life activities) should provide valuable information to patients, their families, and health care providers coping with post- transplantation management. Moreover, elucidating the causes of functional limitations and disability following transplant may identify new areas for intervention that may lead to improved outcomes, in particular HRQL.
DESCRIPTION (provided by applicant): Health related quality of life (HRQL) is a key, patient-centered outcome in lung transplantation. While HRQL may improve following transplantation, available data indicate that HRQL remains well below that of the general population. In theoretical models of disablement, the domain of functional limitation leads to disability and both are precursors to and, therefore, "upstream" determinants of HRQL. To date, the determinants of HRQL and the role of persistent limitations and associated disability in the HRLQ limitations following transplant have not been elucidated. The central study hypotheses are that patients with end-stage lung disease will suffer from functional limitations, disability, and poor HRQL and that following transplantation, both pulmonary and non-pulmonary organ dysfunction, associated in part with therapies required to preserve graft function, will account for residual functional limitations, ongoing disability, and persistently reduced HRQL. A prospective cohort study is proposed to assess functional limitations, disability, and HRQL in patients with end-stage lung disease before and after lung transplantation. Prior to transplantation, subjects will complete a structured survey assessing functional limitations, disability, HRQL. In addition, tests of lung function, exercise capacity (6 minute walk test), and lower extremity strength will be performed. Supplemental data related to the disease indication for transplantation, disease severity and comorbidities will be extracted from medical records. Key measures will be repeated at 3, 6, and 12 months after lung transplantation. Baseline data will be used as follows: to elucidate the impact of end- stage lung disease on functional limitation, disability, and HRQL on patients awaiting lung transplantation. Longitudinal data will be used as follows: to assess the impact of lung transplantation on measures of functional limitation, disability, and HRQL and to identify sources of persistent or new limitations or disabilities that may affect HRQL. We intend to study 30 subjects using repeated measures analysis and allowing for sufficient study power to detect an 0.5 SD change (consistent with a clinically meaningful difference) in key outcome measures.
PUBLIC HEALTH RELEVANCE: Characterizing how lung transplantation enables or does not assist patients with end-stage lung disease to return to participating in activities they rate as meaningful (valued life activities) should provide valuable information to patients, their families, and health care providers coping with post- transplantation management. Moreover, elucidating the causes of functional limitations and disability following transplant may identify new areas for intervention that may lead to improved outcomes, in particular HRQL.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jonathan Paul Singer其他文献
Jonathan Paul Singer的其他文献
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{{ truncateString('Jonathan Paul Singer', 18)}}的其他基金
The impact of body composition on peri-operative and patient-centered outcomes in lung transplantation.
身体成分对肺移植围手术期和以患者为中心的结果的影响。
- 批准号:
10677598 - 财政年份:2022
- 资助金额:
$ 6.33万 - 项目类别:
The impact of body composition on peri-operative and patient-centered outcomes in lung transplantation.
身体成分对肺移植围手术期和以患者为中心的结果的影响。
- 批准号:
10429878 - 财政年份:2022
- 资助金额:
$ 6.33万 - 项目类别:
Frailty and patient centered outcomes in candidates for lung transplantation
肺移植候选人的虚弱和以患者为中心的结果
- 批准号:
10191001 - 财政年份:2017
- 资助金额:
$ 6.33万 - 项目类别:
The Effects of Lung Transplant on Disability and Health-Related Quality of Life
肺移植对残疾和健康相关生活质量的影响
- 批准号:
8534269 - 财政年份:2012
- 资助金额:
$ 6.33万 - 项目类别:
The Effects of Lung Transplant on Disability and Health-Related Quality of Life
肺移植对残疾和健康相关生活质量的影响
- 批准号:
8374331 - 财政年份:2012
- 资助金额:
$ 6.33万 - 项目类别:
The Effects of Lung Transplant on Disability and Health-Related Quality of Life
肺移植对残疾和健康相关生活质量的影响
- 批准号:
9114646 - 财政年份:2012
- 资助金额:
$ 6.33万 - 项目类别:
The Effects of Lung Transplant on Disability and Health-Related Quality of Life
肺移植对残疾和健康相关生活质量的影响
- 批准号:
8703763 - 财政年份:2012
- 资助金额:
$ 6.33万 - 项目类别:
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