The effects of lung transplantation on lung disease related disabilities
肺移植对肺病相关残疾的影响
基本信息
- 批准号:8057964
- 负责人:
- 金额:$ 6.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-06-30 至 2012-06-29
- 项目状态:已结题
- 来源:
- 关键词:AccountingAdultAffectAnxietyAreaBlood VesselsCohort StudiesComorbidityDataDiabetes MellitusDiseaseExerciseFamily health statusFunctional disorderGeneral PopulationHealth PersonnelHypertensionImpairmentInfectionInterventionKidney FailureLeadLifeLower ExtremityLungLung TransplantationLung diseasesMeasuresMedical RecordsMental DepressionMyopathyOrganOsteoporosisOutcomeOutcome MeasurePatient-Focused OutcomesPatientsPerformancePharmaceutical PreparationsPulmonary function testsRecurrenceResidual stateRespiratory physiologyRoleSF-12Severity of illnessSkeletal MuscleSleeplessnessSourceStagingStructureSurveysSystemic diseaseTestingTheoretical modelTherapeutic InterventionTransplant RecipientsTransplantationValue of LifeWalkingcancer riskcopingdisabilitygraft functionhealth related quality of lifeimprovedmuscle strengthnovelprospective
项目摘要
DESCRIPTION (provided by applicant): Health related quality of life (HRQL) is a key, patient-centered outcome in lung transplantation. While HRQL may improve following transplantation, available data indicate that HRQL remains well below that of the general population. In theoretical models of disablement, the domain of functional limitation leads to disability and both are precursors to and, therefore, "upstream" determinants of HRQL. To date, the determinants of HRQL and the role of persistent limitations and associated disability in the HRLQ limitations following transplant have not been elucidated. The central study hypotheses are that patients with end-stage lung disease will suffer from functional limitations, disability, and poor HRQL and that following transplantation, both pulmonary and non-pulmonary organ dysfunction, associated in part with therapies required to preserve graft function, will account for residual functional limitations, ongoing disability, and persistently reduced HRQL. A prospective cohort study is proposed to assess functional limitations, disability, and HRQL in patients with end-stage lung disease before and after lung transplantation. Prior to transplantation, subjects will complete a structured survey assessing functional limitations, disability, HRQL. In addition, tests of lung function, exercise capacity (6 minute walk test), and lower extremity strength will be performed. Supplemental data related to the disease indication for transplantation, disease severity and comorbidities will be extracted from medical records. Key measures will be repeated at 3, 6, and 12 months after lung transplantation. Baseline data will be used as follows: to elucidate the impact of end- stage lung disease on functional limitation, disability, and HRQL on patients awaiting lung transplantation. Longitudinal data will be used as follows: to assess the impact of lung transplantation on measures of functional limitation, disability, and HRQL and to identify sources of persistent or new limitations or disabilities that may affect HRQL. We intend to study 30 subjects using repeated measures analysis and allowing for sufficient study power to detect an 0.5 SD change (consistent with a clinically meaningful difference) in key outcome measures.
PUBLIC HEALTH RELEVANCE: Characterizing how lung transplantation enables or does not assist patients with end-stage lung disease to return to participating in activities they rate as meaningful (valued life activities) should provide valuable information to patients, their families, and health care providers coping with post- transplantation management. Moreover, elucidating the causes of functional limitations and disability following transplant may identify new areas for intervention that may lead to improved outcomes, in particular HRQL.
描述(由申请人提供):健康相关的生活质量(HRQL)是肺移植中以患者为中心的关键结果。虽然移植后 HRQL 可能会有所改善,但现有数据表明 HRQL 仍远低于一般人群。在残疾的理论模型中,功能限制领域会导致残疾,两者都是 HRQL 的先兆,因此也是 HRQL 的“上游”决定因素。迄今为止,HRQL 的决定因素以及移植后持续限制和相关残疾在 HRLQ 限制中的作用尚未阐明。 研究的中心假设是,终末期肺病患者将遭受功能限制、残疾和 HRQL 差的困扰,移植后,肺和非肺器官功能障碍(部分与保留移植物功能所需的治疗相关)将导致残余功能限制、持续残疾和 HRQL 持续降低。 拟开展一项前瞻性队列研究,以评估肺移植前后终末期肺病患者的功能限制、残疾和 HRQL。在移植之前,受试者将完成一项结构化调查,评估功能限制、残疾、HRQL。此外,还将进行肺功能、运动能力(6分钟步行测试)和下肢力量的测试。将从医疗记录中提取与移植疾病适应症、疾病严重程度和合并症相关的补充数据。肺移植后 3、6 和 12 个月将重复关键措施。基线数据将用于:阐明终末期肺病对等待肺移植患者的功能限制、残疾和 HRQL 的影响。纵向数据将用于以下目的:评估肺移植对功能限制、残疾和 HRQL 测量的影响,并确定可能影响 HRQL 的持续或新的限制或残疾的来源。我们打算使用重复测量分析来研究 30 名受试者,并允许足够的研究功效来检测关键结果测量中 0.5 SD 的变化(与临床上有意义的差异一致)。
公共卫生相关性:描述肺移植如何能够或不帮助终末期肺病患者恢复参与他们认为有意义的活动(有价值的生活活动),应该为患者、其家人和应对移植后管理的医疗保健提供者提供有价值的信息。此外,阐明移植后功能限制和残疾的原因可能会确定新的干预领域,从而改善结果,特别是 HRQL。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jonathan Paul Singer其他文献
Jonathan Paul Singer的其他文献
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{{ truncateString('Jonathan Paul Singer', 18)}}的其他基金
The impact of body composition on peri-operative and patient-centered outcomes in lung transplantation.
身体成分对肺移植围手术期和以患者为中心的结果的影响。
- 批准号:
10677598 - 财政年份:2022
- 资助金额:
$ 6.33万 - 项目类别:
The impact of body composition on peri-operative and patient-centered outcomes in lung transplantation.
身体成分对肺移植围手术期和以患者为中心的结果的影响。
- 批准号:
10429878 - 财政年份:2022
- 资助金额:
$ 6.33万 - 项目类别:
Frailty and patient centered outcomes in candidates for lung transplantation
肺移植候选人的虚弱和以患者为中心的结果
- 批准号:
10191001 - 财政年份:2017
- 资助金额:
$ 6.33万 - 项目类别:
The Effects of Lung Transplant on Disability and Health-Related Quality of Life
肺移植对残疾和健康相关生活质量的影响
- 批准号:
8534269 - 财政年份:2012
- 资助金额:
$ 6.33万 - 项目类别:
The Effects of Lung Transplant on Disability and Health-Related Quality of Life
肺移植对残疾和健康相关生活质量的影响
- 批准号:
8374331 - 财政年份:2012
- 资助金额:
$ 6.33万 - 项目类别:
The Effects of Lung Transplant on Disability and Health-Related Quality of Life
肺移植对残疾和健康相关生活质量的影响
- 批准号:
9114646 - 财政年份:2012
- 资助金额:
$ 6.33万 - 项目类别:
The Effects of Lung Transplant on Disability and Health-Related Quality of Life
肺移植对残疾和健康相关生活质量的影响
- 批准号:
8703763 - 财政年份:2012
- 资助金额:
$ 6.33万 - 项目类别:
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