Three-day scientific conference to be held April 18-20, 2012

为期三天的科学会议将于2012年4月18日至20日举行

• 批准号: 8256406
• 负责人: RAYMOND A SWANSON
• 金额: $ 2万
• 依托单位: NORTHERN CALIFORNIA INSTITUTE/RES/EDU
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8256406
• 关键词: Acute; Address; Affect; Aging; Alzheimer' s Disease; Area; Bioenergetics; Brain; California; Cells; Chronic; Collaborations; Critiques; Disease; Disease model; Emerging Technologies; Energy Metabolism; Environment; Evaluation; Fostering; Functional disorder; Future; Gene Mutation; Goals; Heterogeneity; Human Genetics; Image; Imaging technology; In Vitro; Individual; Inflammation; International; Knowledge; Learning; Location; Measures; Metabolic; Methodology; Mitochondria; Nose; Parkinson' s Dementia; Pathway interactions; Physiology; Research; Research Personnel; Resolution; Role; Scientist; Specialist; Structure; Study Section; Technology; Travel; Underrepresented Minority; Update; Woman; Writing; base; brain metabolism; cell type; imaging modality; improved; in vivo; meetings; nervous system disorder; neurotransmission; new technology; normal aging; programs; stem; symposium; web page

DESCRIPTION: Brain energy requirements are exceedingly high. Most, if not all neurological disorders manifest abnormalities in brain energy metabolism, but remarkably little is known about how these abnormalities in brain energy metabolism contribute to neurological disorders. This knowledge gap stems in part from the high degree of complexity and heterogeneity of brain energetic pathways and mechanisms. The goal of this meeting is to identify tractable knowledge gaps in this area, with special emphasis on new technologies now becoming available for high-resolution imaging of energy metabolism in vitro and in vivo. To this end we will invite speakers with expertise in brain bioenergetics, relevant cutting-edge technology, and specific disease pathophysiology. We propose a program that pulls together, in a very interactive forum, investigators from research areas who would otherwise have little interaction: clinicians, neuroscientists, mitochondrial physiologists, and technology pioneers. New imaging technologies now permit cell-type specific and single cell resolution of brain energy metabolism in experimental disease models, and non-invasive imaging methods continue to improve our ability to evaluate metabolic and functional changes associated with disease and aging in vivo. To facilitate progress in this field it is important that the technology pioneers present these advances to a critical audience, and that disease-oriented researchers become educated as to the availability, capacities, and limitations of these new methodologies. There is no other meeting or conference that serves this purpose. The ICBEM meeting we propose here will provide a unique venue for these cross-disciplinary interactions: e.g. for in vivo imaging specialists to converse with experts in neurological diseases and with hard-nosed basic scientists who may challenge some assumptions inherent in vivo imaging; for basic scientists with expertise in mitochondrial physiology and brain energetics to critique human genetics studies assigning cause- effect relationships to mitochondrial and other gene mutations; and for basic scientists and technology pioneers to take away the key questions being addressed by the disease-focused researchers. Outline of Sessions/Topics: I. Intercellular compartmentalization of brain energy metabolism in normal neurotransmission. II. Emerging technologies for measuring brain bioenergetics. III. Effects of normal aging on brain energetics. IV. Brain energetics in neurological disorders - acute & chronic inflammation - Alzheimer's diseases- microvascular dementia - Parkinsons' and related diseases PUBLIC HEALTH RELEVANCE: This research conference will promote our understanding of how changes in energy metabolism affect brain function in neurological disease and normal aging. The conference will provide a forum for neuroscientists and disease-focused investigators to learn about and critique emerging technologies in high resolution brain metabolism imaging, and will allow technology pioneers to learn about the key questions facing neuroscientists and disease-focused investigators. These interactions are important for facilitating progress in these research areas. Disclaimer: Please note that the following critiques were prepared by the reviewers prior to the Study Section meeting and are provided in an essentially unedited form. While there is opportunity for the reviewers to update or revise their written evaluation, based upon the group's discussion, there is no guarantee that individual critiques have been updated subsequent to the discussion at the meeting. Therefore, the critiques may not fully reflect the final opinions of th individual reviewers at the close of group discussion or the final majority opinion of the group. Thus the Resume and Summary of Discussion is the final word on what the reviewers actually considered critical at the meeting.

描述：大脑的能量需求非常高。大多数（如果不是所有的话）神经系统疾病表现为脑能量代谢异常，但对脑能量代谢异常如何导致神经系统疾病知之甚少。这种知识差距部分源于大脑能量通路和机制的高度复杂性和异质性。本次会议的目标是确定在这一领域的知识差距，特别强调新技术，现在成为可用于体外和体内能量代谢的高分辨率成像。为此，我们将邀请具有脑生物能量学，相关尖端技术和特定疾病病理生理学专业知识的演讲者。我们提出了一个计划，在一个非常互动的论坛上，来自研究领域的研究人员将很少有互动：临床医生，神经科学家，线粒体生理学家和技术先驱。新的成像技术现在允许在实验疾病模型中对脑能量代谢进行细胞类型特异性和单细胞分辨率，并且非侵入性成像方法继续提高我们评估体内与疾病和衰老相关的代谢和功能变化的能力。为了促进这一领域的进展，重要的是，技术先驱将这些进展介绍给关键的受众，并以疾病为导向的研究人员接受教育，了解这些新方法的可用性，能力和局限性。 没有任何其他会议或大会能达到这一目的。我们在此提议的ICBEM会议将为这些跨学科的互动提供一个独特的场所：例如，体内成像专家可以与神经疾病专家和可能挑战体内成像固有的一些假设的务实的基础科学家进行对话;对于具有线粒体生理学和大脑能量学专业知识的基础科学家来说，影响线粒体和其他基因突变的关系;基础科学家和技术先驱带走了疾病研究人员正在解决的关键问题。 会议/主题：I。正常神经传递中脑能量代谢的细胞间区室化。 二.测量大脑生物能量学的新兴技术。 三.正常老化对大脑能量学的影响。 四.神经系统疾病中的脑能量学-急性和慢性炎症-阿尔茨海默病-微血管性痴呆-帕金森病和相关疾病 公共卫生关系：这次研究会议将促进我们对能量代谢变化如何影响神经系统疾病和正常衰老中的脑功能的理解。 会议将为神经科学家和以疾病为重点的研究人员提供一个论坛，以了解和批评高分辨率脑代谢成像的新兴技术，并将使技术先驱了解神经科学家和以疾病为重点的研究人员面临的关键问题。 这些互动对于促进这些研究领域的进展非常重要。 免责声明：请注意，以下评论是由审查员在研究部分会议之前准备的，并且以基本上未经编辑的形式提供。 虽然审查人员有机会根据小组讨论情况更新或修订其书面评价，但不能保证在会议讨论之后更新了个人评论。 因此，这些评论可能并不完全反映小组讨论结束时个人评论员的最终意见或小组的最终多数意见。因此，讨论的简历和摘要是评审员在会议上实际认为关键的最后一句话。