2012 Pineal Cell Biology Gordon Research ConferenceLinks to circadian clocks, sl

描述(由申请人提供)：第12届戈登松果体细胞生物学研究会议(GRC)将于2012年1月29日至2月3日在德克萨斯州加尔维斯顿的Galvez酒店举行，现请求部分支持。2012年GRC的主要目标和长期目标将是增加我们对松果体及其激素褪黑素与生物钟计时系统、睡眠/醒来处理和新陈代谢之间的分子网络和生化途径的了解。副标题：与时钟、睡眠和新陈代谢的联系，2012 GRC将侧重于了解这些功能的潜在机制和网络以及健康和疾病中代谢紊乱、睡眠和昼夜节律紊乱之间的相互作用方面的最新进展。松果体和褪黑素在这些相互作用中的作用将被特别讨论。最近的研究表明，生物钟和新陈代谢之间、睡眠不足和代谢紊乱之间以及昼夜节律、光线和睡眠之间存在明显的联系。GRC的具体目标是：1)提供一个交流近期研究进展的论坛，将昼夜节律、褪黑素、睡眠和新陈代谢联系起来，从而确定未来研究的关键机会；2)促进受过这些不同学科培训的研究人员之间的互动，以促进对跨学科和协作研究潜力的了解；3)通过汇聚来自不同研究领域和国家的科学家，并接受不同水平的培训，促进研究合作；以及4)通过将研究人类主题的研究人员与研究其他物种的研究人员聚集在一起，促进翻译研究。GRC将通过为来自这些不同领域的研究人员提供一个独特和及时的机会来会面、辩论和讨论，从而实现这些目标。到目前为止，还没有任何会议完全致力于这一新兴的新陈代谢、睡眠和昼夜节律的跨学科领域。讨论的主题将从基因到行为，并将涵盖从基础科学到使用不同模型系统的翻译研究等领域。来自学术界、政府和工业界的来自这些相关领域的世界领先专家汇聚一堂，将为与会者提供独特的思想交流、“开箱即用”的思维和新的研究网络机会。GRC早晚讲座的形式，有充足的讨论时间，是促进这些科学互动的完美方式。初级科学家和研究生也将有机会以海报形式展示他们的工作，并与该领域的领导者交流想法。对与会者和这个新兴的跨学科领域的好处将是深远的。代谢性疾病(代谢综合征、糖尿病、肥胖)、睡眠限制和昼夜节律紊乱(如轮班工作睡眠障碍)在当今社会日益增多，因此，至关重要的是产生关于这些功能联系过程的新知识，这最终将使国家的健康和经济受益。 公共卫生相关性：最近的研究表明，昼夜节律系统、松果体褪黑素、睡眠和新陈代谢之间存在相互作用。会议的目标是首次将这些不同学科的世界领先科学家聚集在一起，讨论新的发展，提高各学科之间的互动和交流水平，从而促进合作和转化性研究。对这些过程之间潜在的生物学机制和相互作用的深入了解将最终为昼夜节律睡眠障碍和代谢性疾病(如糖尿病、轮班工作障碍)提供新的治疗策略。 免责声明：请注意，以下批评是由评审员在研究小组会议之前准备的，基本上是以未经编辑的形式提供的。虽然审查员有机会根据小组的讨论更新或修订其书面评价，但不能保证在会议讨论之后更新了个别批评意见。因此，这些评论可能不能完全反映评审员在小组讨论结束时的最终意见或小组的最终多数意见。因此，讨论纪要和总结是审查员在会议上实际上认为至关重要的最后结论。

DESCRIPTION (provided by applicant): Partial support is requested for the 12th Gordon Research Conference (GRC) on Pineal Cell Biology to be held January 29 - February 3, 2012 at Hotel Galvez in Galveston, Texas. The major objectives and long- term goals of the 2012 GRC will be to increase our understanding of the molecular networks and biochemical pathways linking the pineal gland and its hormone melatonin with the circadian clock timing system, sleep/wake processing and metabolism. Subtitled: Links to clocks, sleep and metabolism, the 2012 GRC will focus on the very recent advances in understanding the underlying mechanisms and networks linking these functions as well as the interaction between metabolic disorders, sleep and circadian disturbances in health and disease. The role of the pineal gland and melatonin, in these interactions will be specifically addressed. Recent research has demonstrated clear links between circadian clocks and metabolism, between sleep deprivation and metabolic disorders and between circadian rhythms, light and sleep. The specific aims of the GRC are to: 1) Provide a forum for communication of recent research advances linking circadian rhythms, melatonin, sleep and metabolism, thus leading to identification of key opportunities for future study, 2) Stimulate interaction among the researchers trained in these different disciplines, so as to promote understanding of the potential for interdisciplinary and collaborative research, 3) Promote research collaboration by bringing together scientists from different research areas and countries, with different levels of training, including groups typicaly underrepresented in science and 4) Promote translational research by bringing together investigators studying human subjects with those investigating other species. The GRC will achieve these aims by providing a unique and timely opportunity for researchers from these diverse areas to meet, debate and discuss. To date no conference has been dedicated entirely to this newly emerging supra- disciplinary field of metabolism, sleep and circadian rhythms. Topics for discussion will range from genes to behavior and will cover areas from basic science to translational research using different model systems. Bringing together world leading experts from these related fields, from academia, government and industry, will allow a unique cross-fertilization of ideas, "out-of-the box" thinking and new research networking opportunities for attendees. The GRC format of lecture sessions in the morning and evening, with ample time for discussion is perfect to promote these scientific interactions. There will also be opportunities fo junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. The benefits for the attendees and for this emerging supra-disciplinary field will be far-reaching. Metabolic disorders (metabolic syndrome, diabetes, obesity), sleep restriction and circadian rhythm disorders (e.g. shift work sleep disorder) are increasing in today's society thus it is crucial that new knowledge of the processes linking these functions is generated which will ultimately benefit the nation's health and economy. PUBLIC HEALTH RELEVANCE: Recent research has demonstrated interactions between the circadian timing system, pineal melatonin, sleep and metabolism. The Conference objective is to bring together for the first time, world leading scientists in these different disciplines to discuss new developments, to increase the level of interaction and cross-fertilization between the disciplines and thus promote collaboration and translational research. Increased understanding of the underlying biological mechanisms and interactions between these processes will ultimately provide novel treatment strategies for circadian rhythm sleep disorders and metabolic disease (such as diabetes, shift work disorder). Disclaimer: Please note that the following critiques were prepared by the reviewers prior to the Study Section meeting and are provided in an essentially unedited form. While there is opportunity for the reviewers to update or revise their written evaluation, based upon the group's discussion, there is no guarantee that individual critiques have been updated subsequent to the discussion at the meeting. Therefore, the critiques may not fully reflect the final opinions of th individual reviewers at the close of group discussion or the final majority opinion of the group. Thus the Resume and Summary of Discussion is the final word on what the reviewers actually considered critical at the meeting.