2012 Pineal Cell Biology Gordon Research ConferenceLinks to circadian clocks, sl

描述（由申请人提供）：部分支持要求为第12届戈登研究会议（GRC）的松果体细胞生物学将于2012年1月29日至2月3日在酒店加尔维斯顿加尔维斯顿，得克萨斯州。2012年GRC的主要目标和长期目标将是增加我们对联系松果体及其激素褪黑激素与生物钟计时系统、睡眠/觉醒处理和代谢的分子网络和生物化学途径的理解。副标题：联系时钟，睡眠和新陈代谢，2012年的GRC将集中在理解的基础机制和网络连接这些功能以及代谢紊乱，睡眠和昼夜节律紊乱之间的相互作用在健康和疾病的最新进展。松果体和褪黑激素在这些相互作用中的作用将被具体解决。最近的研究表明，生物钟和新陈代谢之间，睡眠剥夺和代谢紊乱之间，以及昼夜节律，光线和睡眠之间存在明确的联系。该委员会的具体目标是：1）提供一个论坛，交流联系昼夜节律，褪黑激素，睡眠和代谢的最新研究进展，从而确定未来研究的关键机会，2）刺激在这些不同学科中受过训练的研究人员之间的互动，以促进对跨学科和合作研究潜力的理解，3）通过汇集来自不同研究领域和国家的科学家来促进研究合作，包括在科学领域代表性不足的群体，以及4）通过汇集研究人类受试者的研究人员与研究其他物种的研究人员来促进转化研究。GRC将通过为来自这些不同领域的研究人员提供独特而及时的会面、辩论和讨论机会来实现这些目标。到目前为止，还没有一个会议完全致力于这个新兴的跨学科领域的新陈代谢，睡眠和昼夜节律。讨论的主题将从基因到行为，并将涵盖从基础科学到使用不同模型系统的转化研究的领域。将来自学术界、政府和工业界的这些相关领域的世界领先专家聚集在一起，将为与会者提供独特的思想交流、“开箱即用”思维和新的研究网络机会。在上午和晚上的讲座会议的GRC格式，有足够的时间进行讨论是完美的，以促进这些科学的互动。也将有机会为年轻的科学家和研究生介绍他们的工作在海报格式和交流思想与领导人在该领域。对于与会者和这个新兴的超学科领域的好处将是深远的。代谢紊乱（代谢综合征、糖尿病、肥胖症）、睡眠限制和昼夜节律紊乱（例如轮班工作睡眠紊乱）在当今社会中日益增多，因此产生关于将这些功能联系起来的过程的新知识至关重要，这将最终有益于国家的健康和经济。 公共卫生相关性：最近的研究表明，昼夜节律计时系统，松果体褪黑激素，睡眠和新陈代谢之间的相互作用。会议的目标是首次将这些不同学科的世界领先科学家聚集在一起，讨论新的发展，提高学科之间的互动和交流水平，从而促进合作和转化研究。对这些过程之间的潜在生物学机制和相互作用的进一步理解将最终为昼夜节律睡眠障碍和代谢疾病（如糖尿病，轮班工作障碍）提供新的治疗策略。 免责声明：请注意，以下评论是由审查员在研究部分会议之前准备的，并且以基本上未经编辑的形式提供。 虽然审查人员有机会根据小组讨论情况更新或修订其书面评价，但不能保证在会议讨论之后更新了个人评论。 因此，这些评论可能并不完全反映小组讨论结束时个人评论员的最终意见或小组的最终多数意见。因此，讨论的简历和摘要是评审员在会议上实际认为关键的最后一句话。

DESCRIPTION (provided by applicant): Partial support is requested for the 12th Gordon Research Conference (GRC) on Pineal Cell Biology to be held January 29 - February 3, 2012 at Hotel Galvez in Galveston, Texas. The major objectives and long- term goals of the 2012 GRC will be to increase our understanding of the molecular networks and biochemical pathways linking the pineal gland and its hormone melatonin with the circadian clock timing system, sleep/wake processing and metabolism. Subtitled: Links to clocks, sleep and metabolism, the 2012 GRC will focus on the very recent advances in understanding the underlying mechanisms and networks linking these functions as well as the interaction between metabolic disorders, sleep and circadian disturbances in health and disease. The role of the pineal gland and melatonin, in these interactions will be specifically addressed. Recent research has demonstrated clear links between circadian clocks and metabolism, between sleep deprivation and metabolic disorders and between circadian rhythms, light and sleep. The specific aims of the GRC are to: 1) Provide a forum for communication of recent research advances linking circadian rhythms, melatonin, sleep and metabolism, thus leading to identification of key opportunities for future study, 2) Stimulate interaction among the researchers trained in these different disciplines, so as to promote understanding of the potential for interdisciplinary and collaborative research, 3) Promote research collaboration by bringing together scientists from different research areas and countries, with different levels of training, including groups typicaly underrepresented in science and 4) Promote translational research by bringing together investigators studying human subjects with those investigating other species. The GRC will achieve these aims by providing a unique and timely opportunity for researchers from these diverse areas to meet, debate and discuss. To date no conference has been dedicated entirely to this newly emerging supra- disciplinary field of metabolism, sleep and circadian rhythms. Topics for discussion will range from genes to behavior and will cover areas from basic science to translational research using different model systems. Bringing together world leading experts from these related fields, from academia, government and industry, will allow a unique cross-fertilization of ideas, "out-of-the box" thinking and new research networking opportunities for attendees. The GRC format of lecture sessions in the morning and evening, with ample time for discussion is perfect to promote these scientific interactions. There will also be opportunities fo junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. The benefits for the attendees and for this emerging supra-disciplinary field will be far-reaching. Metabolic disorders (metabolic syndrome, diabetes, obesity), sleep restriction and circadian rhythm disorders (e.g. shift work sleep disorder) are increasing in today's society thus it is crucial that new knowledge of the processes linking these functions is generated which will ultimately benefit the nation's health and economy. PUBLIC HEALTH RELEVANCE: Recent research has demonstrated interactions between the circadian timing system, pineal melatonin, sleep and metabolism. The Conference objective is to bring together for the first time, world leading scientists in these different disciplines to discuss new developments, to increase the level of interaction and cross-fertilization between the disciplines and thus promote collaboration and translational research. Increased understanding of the underlying biological mechanisms and interactions between these processes will ultimately provide novel treatment strategies for circadian rhythm sleep disorders and metabolic disease (such as diabetes, shift work disorder). Disclaimer: Please note that the following critiques were prepared by the reviewers prior to the Study Section meeting and are provided in an essentially unedited form. While there is opportunity for the reviewers to update or revise their written evaluation, based upon the group's discussion, there is no guarantee that individual critiques have been updated subsequent to the discussion at the meeting. Therefore, the critiques may not fully reflect the final opinions of th individual reviewers at the close of group discussion or the final majority opinion of the group. Thus the Resume and Summary of Discussion is the final word on what the reviewers actually considered critical at the meeting.