2011 Biological Molecules in the Gas Phase and in Solution GRC

描述（由申请人提供）：戈登研究会议“气相和溶液中的生物分子”将于2011年7月31日至8月5日在新罕布什尔州安多弗的Proctor学院举行。戈登研究会议（GRC）将提供一个国际论坛，讨论与蛋白质、多肽、核酸、碳水化合物和其他生命分子构建块的结构和动力学相关的基本问题。本次会议的一个重点是通过质谱和相关方法（包括化学标记，离子迁移率和各种解离方法）表征生物分子。另一个重点是利用光谱学工具对生物分子系统进行研究。此外，会议将突出关键的计算和理论贡献。将要解决的一些问题包括：一旦生物分子被剥夺了水环境，它们会如何表现？如何用气相法获得溶液中生物分子的结构信息？生物分子如何与水相互作用？生物分子在除水以外的溶剂中表现如何？这次会议的独特性源于其强烈的跨学科特征，因为它汇集了在化学，生物学，物理学和医学界面工作的实验学家和理论家。该GRC还为年轻科学家提供了与所有这些领域的成熟和新兴领导者互动的绝佳机会。会议主席召集了一个尖端的项目，其中包括36名顶尖科学家，他们都已确认出席。除了受邀的口头报告外，还有几次海报会议。会议日程可在网上（http://www.grc.org/programs.aspx?year=2011&program=gasphase）查阅。

DESCRIPTION (provided by applicant): Support is requested for the Gordon Research Conference on "Biological Molecules in the Gas Phase and in Solution", which will take place during the week of July 31 to August 5, 2011 at Proctor Academy, Andover, New Hampshire. This Gordon Research Conference (GRC) will provide an international forum for discussing fundamental questions related to the structure and dynamics of proteins, peptides, nucleic acids, carbohydrates, and other molecular building blocks of life. One focus of this meeting is the characterization of biological molecules by mass spectrometry and related approaches (including chemical labeling, ion mobility and various dissociation methods). Another emphasis is on the interrogation of biomolecular systems by spectroscopic tools. In addition, the conference will highlight key computational and theoretical contributions. Some of the issues that will be addressed include the following: How do biological molecules behave once they have been deprived of their aqueous environment? How can gas phase methods be employed for obtaining structural information on biological molecules in solution? How do biological molecules interact with water? How do biological molecules behave in solvents other than water? The uniqueness of this meeting stems from its strongly interdisciplinary character, as it brings together experimentalists and theorists working at the interface of chemistry, biology, physics, and medicine. This GRC also provides a perfect opportunity for young scientists to interact with established and emerging leaders in all of these areas. The conference chairs have assembled a cutting-edge program that includes 36 leading scientists, all of whom have confirmed their attendance. In addition to invited oral presentations there will be several poster sessions. The conference program is available on-line at http://www.grc.org/programs.aspx?year=2011&program=gasphase). PUBLIC HEALTH RELEVANCE: New developments in medicine and public health in the 21st Century are likely to depend on an improved understanding of the structure, dynamics, and function of biological systems at the molecular level. The Gordon Research Conference on Biological Molecules in the Gas Phase and in Solution was created in 2001 to address this need. The 2011 meeting, the sixth in the series, will especially focus on identifying the frontier areas in biology that will benefit from collaborative research involving the biomolecular mass spectrometry, optical spectroscopy, and computational chemistry modeling communities.