2011 Mammalian Gametogenesis and Embryogenesis Gordon Research Conference

描述（由申请人提供）：本申请为将于2011年8月21日至26日在新罕布什尔州沃特维尔谷度假村举行的第18届戈登哺乳动物配子发生和胚胎发生会议申请部分资金。本次会议为致力于为患者提供最现代治疗方法的临床医生和正在研究配子发生和胚胎发生正常和异常功能的生物学机制的基础科学家提供了一个独特而宝贵的讨论和交流思想的机会。了解卵子和精子产生的分子机制以及胚胎发育的开始对动物物种的持续生存至关重要。生殖生物学的进展不仅在治疗人类不孕症和低生育能力方面有直接的应用，而且在开发避孕方法、农业工程和野生动物保护的新方法方面也有改进。此外，干细胞、多能细胞、配子和早期胚胎为理解表观遗传学、成人疾病的发育起源、表观基因组的环境扰动、核编程和细胞周期调控以及转录、翻译和翻译后控制机制提供了重要的基础研究模型。这些领域对广泛的生物医学应用具有潜在的意义。戈登哺乳动物配子发生和胚胎发生会议的目的是为交流该领域的最新进展提供一个论坛，并通过提供一个促进互动的轻松环境来促进讨论和辩论。戈登会议环境的一个特别重要的方面是让年轻和成熟的研究人员以及国内和国际科学家共同促进交流，从而产生新的想法和促进新的合作。

DESCRIPTION (provided by applicant): This application requests partial funding for the 18th Gordon Conference on Mammalian Gametogenesis and Embryogenesis to be held August 21-26, 2011 at Waterville Valley Resort in Waterville Valley New Hampshire. This conference provides a unique and valuable opportunity for discussion and the exchange of ideas between clinicians devoted to delivering the most modern therapeutic approaches to their patients, and basic scientists who are examining the biological mechanisms that underlie normal and abnormal function of gametogenesis and embryogenesis. Understanding the molecular mechanisms underlying the production of viable eggs and sperm and the initiation of embryonic development is essential for the continued survival of animal species. Advances in reproductive biology have immediate application, not only for the treatment of human infertility and subfertility, but also for improvements in developing contraceptive methods, advances in agricultural engineering and novel approaches to wildlife preservation. Moreover, stem cells, pluripotent cells, gametes and early embryos provide important models for basic research aimed at understanding epigenetics, the developmental origins of adult disease, environmental perturbation of the epigenome, nuclear programming and cell cycle regulation, as well as transcriptional, translational, and post-translational control mechanisms. These areas have potential significance for a wide variety of biomedical applications. The objective of the Gordon Conference on Mammalian Gametogenesis and Embryogenesis is to provide a forum for the exchange of the latest advances in the field, as well as to promote discussion and debate by providing a relaxed setting that fosters interaction. A particularly important aspect of the Gordon Conference setting is the blending of young and established investigators, as well as national and international scientists to promote exchanges that will generate new ideas and facilitate new collaborations. PUBLIC HEALTH RELEVANCE: Understanding the molecular mechanisms underlying the production of viable eggs and sperm and the initiation of embryonic development is essential for the creation of viable healthy offspring. Advances in reproductive biology have immediate application, not only for the treatment of human infertility and the development of new contraceptive methods, but also for a better understanding of environmental influences on the epigenome and the developmental origins of adult disease. The study of gametes and early embryos is critical to our understanding of human reproductive health and disease.