Bioinformatics Expansion Phase III

描述（由申请人提供）： 杰克逊实验室的生物信息学/计算生物学（BI/CB）研究人员是社区数据库开发，统计遗传学和理解基因功能的计算方法开发的国家领导者。这里和更广泛的科学界的生物医学研究人员正在利用丰富的小鼠序列和表型数据来了解与人类疾病和正常发育有关的分子网络。为了应对功能分析对计算方法的日益依赖，BI/CB计划正在扩展，以增加计算生物学的强度，并进一步整合二氧化硅和体内方法以了解基因功能。从长远来看，这种跨学科的合作研究将通过全国性计算网格的发展而得以实现。来自我们的实质性表型和遗传表征计划的丰富注释数据，以及数据可视化和挖掘工具，将为国家的奋进增添力量。为了实现这一目标，杰克逊计划在未来五年内招募四名新的教师，他们在应用计算方法解决生物学问题方面具有专业知识。然而，由于现有项目的快速增长，我们的三层BI/CB区域已满负荷。没有新的招聘或预期的计划扩展的空间。此外，没有足够的空间来容纳不断扩大的计算硬件，以满足BI/CB计划和我们的湿台研究计划日益增长的需求，这些计划越来越依赖于计算。本申请中描述的项目将创建额外的办公室和会议空间，以支持BI/CB计划的扩展。它还将建造一个计算基础设施，创造必要的额外空间，以容纳现有和预期的额外计算硬件，以支持整个杰克逊实验室科学工作人员日益增加的数据和计算密集型研究。

DESCRIPTION (provided by applicant): The Bioinformatics/Computational Biology (BI/CB) investigators at The Jackson Laboratory are national leaders in community database development, statistical genetics, and the development of computational approaches for understanding gene function. Biomedical researchers here and in the wider scientific community are tapping the wealth of mouse sequence and phenotype data to understand the molecular networks involved in human disease and normal development. In response to the increased reliance of functional analyses on computational approaches, the BI/CB programs are expanding to add strength in computational biology and to further integrate in silica and in vivo approaches for understanding gene function. In the long term, such collaborative, interdisciplinary research will be enabled by the development of nationwide computing grids. Richly annotated data from our substantive phenotyping and genetic characterization programs, accompanied by tools for data visualization and mining, will add to the national endeavor. To achieve that goal, Jackson plans to recruit four new faculty members over the next five years with expertise in applying computational approaches to solving biological problems. However, our three-floor BI/CB area is at capacity because of the rapid growth of existing programs. There is no space for new recruits or expected program expansions. In addition, there is insufficient space to house the expanding computing hardware necessary to meet the increased needs of the BI/CB programs and our wet-bench research programs, which are increasingly dependent on computation. The project described in this application will create the additional office and conference space necessary to support expansion of the BI/CB programs. It will also construct a Computing Infrastructure Facility creating the additional space necessary to house the existing and anticipated additional computing hardware required to support the increasingly data- and computationally intense research of the entire Jackson Laboratory scientific staff.