Translational Neuromuscular Research, Diverse Diseases, Convergent Themes

转化神经肌肉研究、多种疾病、趋同主题

• 批准号: 8205103
• 负责人: Robert C Griggs
• 金额: $ 2万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8205103
• 关键词: Academia; Aerobic; Animal Model; Area; Clinical; Clinical Investigator; Clinical Trials; Collaborations; Development; Disease; Environment; Exercise; Exercise Physiology; Faculty; Feedback; Foundations; Funding; Future; Generations; Individual; Industry; International; Lead; Leadership; Learning; Metabolism; Methods; Muscle; Myopathy; Neuromuscular Diseases; Newsletter; Patient advocacy; Patients; Phenotype; Process; Protocols documentation; Publications; Publishing; RNA; Recruitment Activity; Research; Research Personnel; Role; Scientist; Site; Sodium Glutamate; Testing; Therapeutic; Training; Translational Research; United States National Institutes of Health; Work; bench to bedside; design; human disease; improved; meeting abstracts; meetings; neuromuscular; novel; posters; programs; skills; strength training; symposium; therapeutic target; translational clinical trial; treatment strategy; unpublished works; web site

DESCRIPTION (provided by applicant): This application proposes an international conference: "Translational Neuromuscular Research: Diverse Diseases, Convergent Themes". The conference will bring together expert translational and clinical scientists from academia, foundations, and pharma in a collegial forum. This proposal has been developed by a Steering Committee that includes both translational clinical scientists and leadership of the Muscle Study Group. The conference is open to attendance from it and other groups and by individuals not currently affiliated with a study group. The conference's scientific emphasis will be on a number of key "cross cutting" themes that are common to multiple neuromuscular disorders and have important translational potential. This international conference, to be held in an informal, isolated environment, will bring senior investigators, representatives of pharma, NIH program staff, and foundation and patient advocacy representatives together with junior/trainee investigators. The conference will cover a range of topics from bench-to-bedside in muscle disease with the aims (1) to explore the role of RNA metabolism as disease mechanism and as a potential therapeutic target in different neuromuscular diseases; (2) to examine the role of animal models in translational research in neuromuscular disease; (3) to discuss exercise as a therapy in neuromuscular diseases; (4) to provide training for junior faculty in the strategies for developing novel treatment strategies for neuromuscular disease; (5) to provide for interaction/development of collaboration among established investigators and between senior and new/junior investigators. It is expected that the seminar may lead to new collaboration among attendees of various affiliations. Attendees will be invited to submit their work and to participate in an interactive poster discussion session. PUBLIC HEALTH RELEVANCE: This is an application for funds for an international conference for scientists from academia, foundations, and industry to discuss ways to work together and conduct studies of new treatments for neuromuscular diseases, to exchange information about the causes of the diseases, and to recruit new junior scientists to develop and conduct such trials.

描述(由申请者提供)：本申请提出了一个国际会议：“转译神经肌肉研究：多样化的疾病，趋同的主题”。这次会议将汇集来自学术界、基金会和制药行业的专家翻译和临床科学家在一个合议性论坛上。这项建议是由一个指导委员会制定的，该委员会包括翻译临床科学家和肌肉研究小组的领导。该会议向它和其他团体以及目前没有隶属于学习小组的个人开放。会议的科学重点将放在一些关键的“交叉”主题上，这些主题是多种神经肌肉疾病的常见主题，具有重要的翻译潜力。这次国际会议将在非正式、孤立的环境中举行，将把高级调查人员、制药公司的代表、NIH项目工作人员、基金会和患者倡导代表以及初级/见习调查人员聚集在一起。会议将涵盖从板凳到床边的肌肉疾病的一系列主题，目的是(1)探讨RNA代谢作为疾病机制和作为不同神经肌肉疾病潜在治疗靶点的作用；(2)考察动物模型在神经肌肉疾病翻译研究中的作用；(3)讨论运动作为神经肌肉疾病的治疗方法；(4)为初级教员提供培训，以制定神经肌肉疾病的新治疗策略；(5)在现有研究人员之间以及高级和新/初级研究人员之间提供互动/发展协作。预计研讨会可能导致不同从属关系的与会者之间进行新的合作。与会者将被邀请提交他们的作品，并参加一个互动海报讨论环节。 与公共卫生相关：这是一次国际会议的资金申请，来自学术界、基金会和工业界的科学家将讨论如何合作并进行神经肌肉疾病新疗法的研究，交流有关疾病原因的信息，并招募新的初级科学家来开发和进行此类试验。