2011 Plant Metabolic Engineering GRC/GRS

2011 植物代谢工程GRC/GRS

• 批准号: 8118659
• 负责人: Natalia Doudareva
• 金额: $ 0.4万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8118659
• 关键词: Academia; Address; Anabolism; Applied Research; Basic Science; Biochemical Pathway; Biological Factors; Chemistry; Communicable Diseases; Communities; Development; Disabled Persons; Doctor of Philosophy; Drug Compounding; Engineering; Environment; Food; Food Supply; Future; Genetic; Genomics; Health; Human; Industry; Institutes; Institution; Interdisciplinary Study; Joints; Laboratories; Lead; Learning; Mediating; Medicinal Plants; Metabolic; Metabolism; Nutritional; Ownership; Participant; Pharmaceutical Cares; Pharmaceutical Preparations; Plants; Play; Population; Postdoctoral Fellow; Production; Research; Resources; Role; Scientist; Series; Students; Systems Biology; Therapeutic; Therapeutic Agents; Transgenic Plants; Woman; abstracting; base; career; design; drug development; meetings; novel; novel therapeutics; nutrition; peer; posters; prospective; symposium; synthetic biology

DESCRIPTION (provided by applicant): Plants produce over 200,000 natural products that provide the basis to develop novel therapeutic agents to treat the world's most serious ailments. Roughly 75% of the world relies on medicinal plants for primary pharmaceutical care. Natural products are rich resources for drug development comprising 60% of anticancer compounds and 75% of drugs for infectious diseases. Given the multiplicity of chiral centers, elaboration with modifying substituents and important roles these compounds mediate between plants and environment, natural products play an important role in the design and development of two-thirds of all drugs. The current post- genomic era presents new opportunities for manipulating plant chemistry that will further impact the level and nutritional content of global food supply and lead to the development of novel drugs and therapeutic compounds. To establish a setting for advancement of multidisciplinary collaborations needed to unravel the complexity of plant natural product biosynthesis, the dynamics of plant metabolic networks, and advance basic and applied research in plant metabolic engineering in support of drug development activities, we are requesting support for the 2011 Gordon Research Conference (GRC) and joint Graduate Research Seminar (GRS) on Plant Metabolic Engineering to be held July 24-29, 2011 at the Waterville Valley conference center (NH). Similar to prior meetings of this conference series, we expect 175 speakers and participants from the US and abroad, at all career levels, representing institutions from academia, industry, private institutes, and federal laboratories. Concerted efforts will continue to encourage the participation of women, persons with disabilities, and scientists from underrepresented groups. We will host a Graduate Research Seminar (GRS) immediately prior to the GRC. The GRS provides a unique venue for Ph.D. students and postdoctoral fellows to present their research in a setting of their peers, learn to evolve new research ideas, and build a dynamic and interactive scientific community as the GRS participants are fully integrated into the larger GRC meeting. The 2011 GRS will be centered on "Roundtable Discussions" and opportunities for participants to openly discuss issues related to the field in general, as well as future directions thus allowing participants to establish ownership of a field, a community and a meeting venue. All participants to the GRS are expected to stay for the GRC, further enhancing the educational component of this conference. PUBLIC HEALTH RELEVANCE: Plants produce natural products, many of which have a profound and lasting impact on human health. 75% of the world's population relies upon medicinal plants for its primary pharmaceutical care including anticancer compounds and drugs for infectious diseases. The GRC in Plant Metabolic Engineering provides a setting for developing the multidisciplinary collaborations and interactions needed to unravel the complexity of plant metabolism in support of drug development activities, food nutrition, energy production and agronomic production of plants. The preceding 2011 GRS will be centered on "Roundtable Discussions" and opportunities for participants to openly discuss issues related to the field in general, as well as future directions thus allowing participants to establish ownership of a field, a community and a meeting venue.

描述（由申请人提供）：植物生产超过200,000种天然产品，为开发新型治疗剂的基础来治疗世界上最严重的疾病。大约75％的世界依靠药用植物进行初级药物护理。天然产品是占药物开发的丰富资源，其中包括60％的抗癌化合物和75％的传染病药物。鉴于手性中心的多样性，用修饰的取代基和重要作用进行阐述，这些化合物在植物和环境之间介导，天然产品在所有药物的三分之二的设计和开发中起着重要作用。当前的基因组时代为操纵植物化学提供了新的机会，这将进一步影响全球粮食供应的水平和营养含量，并导致新型药物和治疗化合物的发展。建立一个设置，以提高跨学科合作的发展，以揭示植物天然产品生物合成的复杂性，植物代谢网络的动态，并促进植物代谢工程中支持药物开发活动的基本和应用研究，我们要求对2011年Gordon研究会议（GRC）（GRC）的24-GROILION INSINERIN（GRC）的赛车（GRC）（GRC）竞争赛车（GRC），以供植物研究所（GRC）纳入METABILICERIDER，并要求使用Metboility Inginerering，并要求会议中心（NH）。与该会议系列的先前会议类似，我们预计美国和国外的175名演讲者和参与者在所有职业级别上，代表来自学术界，工业，私人机构和联邦实验室的机构。一致的努力将继续鼓励妇女，残疾人和代表性不足的群体的科学家的参与。我们将在GRC之前立即举办研究生研究研讨会（GRS）。 GRS为博士提供了一个独特的场所。学生和博士后研究员在同龄人的情况下介绍他们的研究，学会发展新的研究思想，并建立一个动态和互动的科学界，因为GRS参与者已完全融入了更大的GRC会议。 2011年的GRS将集中在“圆桌讨论”和参与者的机会上，有机会公开讨论与该领域有关的问题以及未来的方向，从而使参与者能够建立一个领域，社区和会议场所的所有权。预计GRS的所有参与者都将留在GRC中，进一步增强了本次会议的教育部分。 公共卫生相关性：植物生产天然产品，其中许多产品对人类健康产生了深远而持久的影响。全球75％的人口依靠药用植物的主要药物护理，包括抗癌化合物和传染病药物。植物代谢工程中的GRC为开发植物代谢在支持药物开发活动，食品营养，能源生产和植物的农艺生产所需的复杂性所需的多学科合作和相互作用提供了设置。前面的2011年GRS将集中在“圆桌讨论”和参与者的机会上，以公开讨论与该领域有关的问题以及未来的指示，从而使参与者能够建立一个领域，社区和会议场所的所有权。