2011 Plant Metabolic Engineering GRC/GRS

植物产生超过200，000种天然产物，为开发治疗世界上最严重疾病的新型治疗剂提供基础。世界上大约75%的人依赖药用植物进行初级药物治疗。天然产物是药物开发的丰富资源，占抗癌药物的60%，占治疗感染性疾病药物的75%。鉴于手性中心的多样性，修饰取代基的修饰以及这些化合物在植物和环境之间介导的重要作用，天然产物在三分之二的药物的设计和开发中发挥着重要作用。当前的后基因组时代为操纵植物化学提供了新的机会，这将进一步影响全球食品供应的水平和营养含量，并导致新型药物和治疗化合物的开发。为了建立一个多学科合作的进步，需要解开植物天然产物生物合成的复杂性，植物代谢网络的动态，并推进植物代谢工程的基础和应用研究，以支持药物开发活动，我们请求支持2011年戈登研究会议（GRC）和联合研究生研究研讨会（GRS）将于2011年7月24日至29日在沃特维尔山谷会议中心（NH）举行。与此系列会议的前几次会议类似，我们预计将有175名来自美国和国外的演讲者和参与者，来自学术界，工业界，私营机构和联邦实验室。协调一致的努力将继续鼓励妇女、残疾人和代表性不足群体的科学家参与。我们将在GRC之前举办研究生研究研讨会（GRS）。GRS为博士提供了一个独特的场所。学生和博士后研究员在他们的同龄人的设置，介绍他们的研究，学习发展新的研究思路，并建立一个充满活力和互动的科学社区作为GRS参与者完全融入更大的GRC会议。2011年全球报告系统将以“圆桌讨论”为中心，为与会者提供机会，公开讨论与该领域有关的一般问题以及未来的方向，从而使与会者能够建立对一个领域、一个社区和一个会议地点的所有权。预计所有参加GRS的人都将参加GRC，进一步加强本次会议的教育部分。 植物生产天然产品，其中许多对人类健康有深远而持久的影响。世界上75%的人口依赖于药用植物的主要药物治疗，包括抗癌化合物和传染病药物。植物代谢工程中的GRC为开发多学科合作和互动提供了一个环境，这些合作和互动需要解开植物代谢的复杂性，以支持药物开发活动，食品营养，能源生产和植物的农艺生产。2011年的GRS将集中于“圆桌讨论”，并为参与者提供公开讨论与该领域有关的一般问题以及未来方向的机会，从而使参与者能够建立对一个领域、一个社区和一个会议地点的所有权。

DESCRIPTION (provided by applicant): Plants produce over 200,000 natural products that provide the basis to develop novel therapeutic agents to treat the world's most serious ailments. Roughly 75% of the world relies on medicinal plants for primary pharmaceutical care. Natural products are rich resources for drug development comprising 60% of anticancer compounds and 75% of drugs for infectious diseases. Given the multiplicity of chiral centers, elaboration with modifying substituents and important roles these compounds mediate between plants and environment, natural products play an important role in the design and development of two-thirds of all drugs. The current post- genomic era presents new opportunities for manipulating plant chemistry that will further impact the level and nutritional content of global food supply and lead to the development of novel drugs and therapeutic compounds. To establish a setting for advancement of multidisciplinary collaborations needed to unravel the complexity of plant natural product biosynthesis, the dynamics of plant metabolic networks, and advance basic and applied research in plant metabolic engineering in support of drug development activities, we are requesting support for the 2011 Gordon Research Conference (GRC) and joint Graduate Research Seminar (GRS) on Plant Metabolic Engineering to be held July 24-29, 2011 at the Waterville Valley conference center (NH). Similar to prior meetings of this conference series, we expect 175 speakers and participants from the US and abroad, at all career levels, representing institutions from academia, industry, private institutes, and federal laboratories. Concerted efforts will continue to encourage the participation of women, persons with disabilities, and scientists from underrepresented groups. We will host a Graduate Research Seminar (GRS) immediately prior to the GRC. The GRS provides a unique venue for Ph.D. students and postdoctoral fellows to present their research in a setting of their peers, learn to evolve new research ideas, and build a dynamic and interactive scientific community as the GRS participants are fully integrated into the larger GRC meeting. The 2011 GRS will be centered on "Roundtable Discussions" and opportunities for participants to openly discuss issues related to the field in general, as well as future directions thus allowing participants to establish ownership of a field, a community and a meeting venue. All participants to the GRS are expected to stay for the GRC, further enhancing the educational component of this conference. PUBLIC HEALTH RELEVANCE: Plants produce natural products, many of which have a profound and lasting impact on human health. 75% of the world's population relies upon medicinal plants for its primary pharmaceutical care including anticancer compounds and drugs for infectious diseases. The GRC in Plant Metabolic Engineering provides a setting for developing the multidisciplinary collaborations and interactions needed to unravel the complexity of plant metabolism in support of drug development activities, food nutrition, energy production and agronomic production of plants. The preceding 2011 GRS will be centered on "Roundtable Discussions" and opportunities for participants to openly discuss issues related to the field in general, as well as future directions thus allowing participants to establish ownership of a field, a community and a meeting venue.