2011 Inhibition in the CNS Gordon Research Conference

2011 CNS 戈登研究会议抑制

• 批准号: 8113527
• 负责人: NEIL L. HARRISON
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8113527
• 关键词: Address; Affect; Alcohols; Anatomy; Area; Biology; Brain; Brain Diseases; Cellular biology; Communication; Communities; Computer Simulation; Development; Drug abuse; Drug effect disorder; Eating; Educational process of instructing; Ensure; Environment; Equilibrium; Food; Fund Raising; Future; Glycine; Goals; Health; Human; Human Development; Inhibitory Synapse; International; Interneurons; Lead; Maine; Minority; Modeling; Neurons; Neurotransmitters; Opiates; Oral; Parents; Participant; Physiology; Play; Postdoctoral Fellow; Regulation; Request for Proposals; Research; Research Personnel; Resolution; Role; Science; Scientist; Secure; Series; Sleep; Stem cells; Students; Synaptic Transmission; Time; Universities; Woman; Work; career; cognitive function; college; design; drug of abuse; gamma-Aminobutyric Acid; interest; lectures; meetings; posters; programs; receptor; research study; sleeping pill; success; symposium

DESCRIPTION (provided by applicant): This proposal requests partial support for an international meeting on Inhibition in the CNS as part of the Gordon Research Conference series to be held in Waterville, Maine, U.S.A. July 24-29, 2011. The broad and long-term goal of the Conference is to increase our understanding of the fundamental mechanisms of inhibitory synaptic transmission, the role of interneurons in regulating excitability and network activity. A significant emphasis is placed on interneuron diversity and how neuronal stem cells differentiate into interneurons, as well as the mechanisms by which drugs of abuse, including opiates and alcohol, influence inhibition in the CNS. The specific aims of this meeting will be to convene 40 speakers that represent critical areas of inhibition research with a total of ~150 participants for a five day conference in a relatively isolated setting. The program will have a keynote address and eight sessions that broadly address current issues in the biology of interneurons. Sessions are typically devoted to the anatomy and physiology of a special subset of neurons in the brain containing the inhibitory transmitter GABA, the function and regulation of inhibitory synapses, and the role these specific interneurons play in regulating and synchronizing the activity of neuronal networks, as well as the cell biology of the receptors gated by the inhibitory neurotransmitters GABA and glycine, and a session devoted to the development of interneurons from stem cells. Speakers will be diverse, with multiple nations featured, and younger investigators and women well represented. In addition, two evening poster sessions will permit all of the participants to interact and contribute to these topics. The significance of this application is that the Gordon Research conference on Inhibition in the CNS is a critical component of the yearly series of conferences that propel research in the international community of inhibition researchers. The health relatedness of this application is that the discussions at this meeting will define the questions that require experimental resolution in areas that affect human development, drug abuse liability and cognitive function. PUBLIC HEALTH RELEVANCE: The Gordon Conference on Inhibition in the CNS is a scientific meeting that is held on the campus of Colby College in Maine. 150 participants from around the world will gather for a five-day meeting, sleeping in dormitories and eating college dorm food, while spending time discussing their scientific work in an isolated setting that promotes conversations among experts who might not otherwise meet. About 40 lectures will be given, and junior scientists are encouraged to attend and to lead the discussion of the work presented. This year's meeting will highlight ground-breaking areas of brain science such as the modeling of human brain wave activity by computer simulations, the actions of drugs such as alcohol and sleeping pills on the brain, and the applications of stem cells for the treatment of human brain disorders. Many new and interesting scientific developments begin as informal conversations between scientists from different parts of the world, who have the unique opportunity at these small meetings to discuss their experiments together in a secure and protected environment that allows for imaginative and creative thought, far away from their university teaching and fund- raising responsibilities.

描述（由申请人提供）：本提案要求对将于2011年7月24日至29日在美国缅因州沃特维尔举行的戈登研究会议系列中的CNS抑制国际会议提供部分支持。会议的广泛和长期目标是增加我们对抑制性突触传递的基本机制，中间神经元在调节兴奋性和网络活动中的作用的理解。 一个重要的重点放在interneuron多样性和神经干细胞分化成interneuron，以及滥用药物，包括阿片类药物和酒精，影响抑制中枢神经系统的机制。 本次会议的具体目标是召集40位代表抑制研究关键领域的发言者，在一个相对孤立的环境中举行为期五天的会议，共有约150名与会者。该计划将有一个主题演讲和八个会议，广泛解决当前的问题，在生物学的interneurons。会议通常致力于大脑中含有抑制性递质GABA的特殊神经元子集的解剖学和生理学，抑制性突触的功能和调节，以及这些特定的中间神经元在调节和同步神经元网络活动中的作用，以及由抑制性神经递质门控的受体的细胞生物学 GABA和甘氨酸，以及一个致力于从干细胞发育中间神经元的会议。发言人将是多样化的，有多个国家的特色，年轻的调查人员和妇女的代表。 此外，两个晚上的海报会议将允许所有参与者互动，并为这些主题作出贡献。这一应用的意义在于，戈登研究会议抑制在中枢神经系统是一个重要组成部分的年度系列会议，推动研究在国际社会的抑制研究人员。 这种应用的健康相关性在于，本次会议的讨论将确定在影响人类发展、药物滥用责任和认知功能的领域需要实验解决的问题。 公共卫生相关性：关于中枢神经系统抑制的戈登会议是在缅因州的科尔比学院校园内举行的一次科学会议。来自世界各地的150名参与者将聚集在一起参加为期五天的会议，睡在宿舍里，吃大学宿舍的食物，同时花时间在一个孤立的环境中讨论他们的科学工作，促进专家之间的对话，否则他们可能不会见面。大约40个讲座将被给予，并鼓励年轻的科学家参加，并领导工作的讨论。 今年的会议将突出脑科学的突破性领域，如通过计算机模拟人类脑电波活动的建模，酒精和安眠药等药物对大脑的作用，以及干细胞在治疗人类大脑疾病中的应用。 许多新的和有趣的科学发展开始是来自世界不同地区的科学家之间的非正式对话，他们在这些小型会议上有独特的机会，在远离大学教学和筹款责任的安全和受保护的环境中一起讨论他们的实验。