7th World Congress on Developmental Origins of Health and Disease - NIH

描述(由申请人提供)：自从David Barker描述了子宫发育不良与成年后患慢性病风险增加之间的关系以来，发展规划领域在20年内迅速扩大。我们现在知道，在围产期、妊娠期和围产期的关键时期，亚最佳状态(如营养不足或营养过剩、压力)与出生后因素(包括饮食)相互作用，放大成年后患慢性疾病的风险；这些疾病包括肥胖症、心脏病、糖尿病和癌症。第七届世界健康与疾病发展起源大会(DOHAD)将于2011年9月18日至21日在美国俄勒冈州波特兰举行。这将是本届大会首次在美国举行，为美国科学家、临床医生和政策制定者提供了一个独特的机会，可以参与与这一全球领域的关键人员的讨论。自2003年国际国防部协会成立以来，尽管有几位该领域的顶尖专家驻扎在美国，但美国成员的代表性一直很低；因此，我们预计美国将更多地参加第七届国防部世界大会。有意列入旨在改变临床实践和公共卫生政策的会议是第七届世界大会的一个新特点，除了大幅降低与慢性病有关的保健费用外，还可能对改善全球成人健康产生重大影响。组织这次两年一度的多学科世界大会有几个目标：(A)传播最新的机械学和干预性研究的结果，(B)汇聚这一广泛领域的专家，并促进他们之间的讨论，(C)促进基础科学家、临床医生和卫生政策制定者之间关于预防或减轻次优宫内环境的长期负面影响的最佳实践的互动。本届大会还将提供一个关键机会，以加深对发展方案拟订领域的了解，并查明知识方面的科学差距。国防部协会长期以来的重点一直是促进初级调查人员、少数族裔和来自发展中国家的代表出席，这一点在第七届世界大会上仍在继续；这些团体将获得基于功绩的旅行补助金。组织了指导午餐会、社交交流会和初级研究员奖会议，以促进早期职业研究人员之间的互动，并启动合作和联系，这些合作和联系对研究领域的长期职业成功至关重要。大会计划包括50多位受邀演讲者(全体会议和平行会议)，以及同行评议的摘要提交的口头和海报演示。摘要将发表在DOHaD杂志上，在大会期间和之后都可以获得。将研究人员、卫生保健工作者和政策制定者聚集在一起的能力促进了这些往往截然不同的群体之间的沟通，并将增加解决与发展规划和健康相关的许多重要问题的可能性。 公共卫生相关性：孕妇的营养不良和营养过剩/肥胖--双重形式的营养不良--都会对胎儿发育产生负面影响，并产生长期影响，增加患常见慢性病的风险：高血压、心血管疾病、肥胖和糖尿病。全球肥胖症流行不断升级，导致女孩和准妈妈肥胖，形成了肥胖和代谢功能障碍跨代传递的恶性循环。这一多学科大会将促进科学家、临床医生和公共卫生政策制定者之间的互动和讨论，以启动对怀孕或育龄妇女的护理方面的关键变革，目标是改善其后代的长期健康。

DESCRIPTION (provided by applicant): The field of developmental programming has rapidly expanded in the two decades since David Barker described a relationship between poor in utero growth and increased vulnerability for chronic disease in adulthood. We now know that sub-optimal conditions (eg under- or overnutrition, stress) during critical windows in the periconceptional, gestational, and perinatal periods interact with postnatal factors (including diet) to amplify the risk for developing chronic diseases in adulthood; these include obesity, heart disease, diabetes and cancer. The 7th World Congress on Developmental Origins of Health and Disease (DOHaD) will be held in Portland, OR, USA on September 18-21, 2011. This will be the first time this Congress has been held in the US and represents a unique opportunity for US scientists, clinicians and policy makers to participate in discussions with key personnel in this worldwide field. Since the inception of the International DOHaD Society in 2003, there has been an underrepresentation of US members despite several leading experts in the field being based in the US; we thus anticipate increased US participation at the 7th World Congress on DOHaD. Deliberate inclusion of sessions geared towards changing clinical practice and public health policies is a novel feature of the 7th World Congress and could have major impacts on improving adult health worldwide, in addition to substantial reductions in the health care costs associated with chronic disease. This biennial multidisciplinary World Congress is being organized with several goals in mind: (a) to disseminate the results from the most recent mechanistic and interventional studies, (b) to bring together, and stimulate discussion between experts in this broad field, (c) to facilitate interactions between basic scientists, clinicians, and health policy makers regarding best practice in preventing or attenuating the long-term negative effects of a sub-optimal intrauterine environment. This Congress will also provide a key opportunity to further understanding in the field of developmental programming and identify scientific gaps in knowledge. A longstanding emphasis of the DOHaD Society has been to promote attendance of junior investigators, minorities, and delegates from developing nations and this continues for the 7th World Congress; merit-based travel grants will be available to these groups. Mentoring luncheons, a social mixer and a Junior Investigator Award session have been organized to foster interactions amongst early career researchers and initiate collaborations and contacts that are so critical for long term career success in research. The Congress program comprises over 50 invited speakers (plenary and parallel sessions), and oral and poster presentations of peer-reviewed abstract submissions. Abstracts will be published in the Journal of DOHaD, available during and after the congress. The ability to bring together researchers, health care workers and policy makers promotes communication between these often disparate groups and will increase the likelihood of solving many of the important issues associated with developmental programming and health. PUBLIC HEALTH RELEVANCE: Both undernutrition and overnutrition/obesity in pregnant mothers - dual forms of malnutrition - negatively impact fetal development with long-term effects to increase vulnerability for common chronic diseases: hypertension, cardiovascular disease, obesity, and diabetes. The escalating worldwide obesity epidemic, leading to obesity in girls and mothers-to-be, sets up a vicious cycle with trans-generational transmission of obesity and metabolic dysfunction. This multi-disciplinary congress will facilitate interactions and discussions between scientists, clinicians and public health policy makers to initiate key changes in care for women who are pregnant or of child bearing age, with a goal of improve the long-term health of their offspring.