Systems dynamics of intracellular communication (Spatial 2011)

细胞内通讯的系统动力学（Spatial 2011）

• 批准号: 8129400
• 负责人: JEFFERY L TWISS
• 金额: $ 1万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8129400
• 关键词: Accounting; Applications Grants; Area; Biology; Budgets; Cell Nucleus; Cell surface; Cells; Chemotaxis; Clinical; Collaborations; Communication; Communities; Complex; Development; Diffusion; Disease; Educational workshop; Etiology; Eukaryotic Cell; Europe; Faculty; Funding; Germany; Health; Human; Immune system; Interest Group; International; Israel; Link; Literature; Methodology; Methods; Nervous system structure; Neurons; Organism; Principal Investigator; Process; Reagent; Request for Applications; Research; Research Personnel; Role; Scientist; Series; Signal Transduction; Signaling Molecule; Students; Switzerland; System; Therapeutic; Travel; United States National Institutes of Health; axon guidance; interest; meetings; novel strategies; planetary Atmosphere; symposium

DESCRIPTION (provided by applicant): This R13 application requests funds to increase participation by US scientists in an EMBO workshop series entitled Systems Dynamics of Intracellular Communication ('Spatial 2011'). Information transfer is a central aspect of biology, and signaling within and between cells is a fundamental aspect of the functioning of multicellular organisms. Signaling over long distances between cells requires specific and regulated mechanisms to transport signaling molecules and generate functional gradients to control processes such as chemotaxis, axon guidance, developmental differentiation and others. In recent years it has become increasingly clear that equally sophisticated and diverse mechanisms are required for information transfer and signaling within cells. Diffusion alone is not sufficient to account for effective transfer of different signals from cell surface to the nucleus against unfavorable enzymatic activities. Long distance communication within cells requires protected or facilitated mechanisms of signal propagation over any intracellular distance of more than a few micrometers. Different communities of researchers are interested in spatial aspects of propagation of intracellular signals and information within cells, including theoreticians, cell biologists, and neurobiologists. Information transfer within large and morphologically complex cells (such as neurons and other polarized eukaryotic cells) requires specialized mechanisms to facilitate propagation and translocation of signals. Spatial 2011 will provide a unique platform for communication and interaction between the experimentalists and theoreticians involved in these diverse research communities. The 2007 and 2009 Spatial meetings (held in Israel) saw participation from relatively few US scientists. We have relocated the venue to central Europe to specifically facilitate US participation and are seeking NIH support to support US representation by young faculty, fellows, and students in this growing interdisciplinary field. PUBLIC HEALTH RELEVANCE: This application seeks funds to support US scientists' participation in a unique interdisciplinary conference focusing on spatial communication in health and disease. Signaling over long distances between cells requires specific and regulated mechanisms to transport signaling molecules and generate functional gradients to control processes such as chemotaxis, axon guidance, developmental differentiation and others. Malfunction of intracellular propagation of survival and other signals in large cells is tightly linked with disease etiology in the nervous and immune systems.

描述(申请人提供)：此R13申请申请资金，以增加美国科学家参与EMBO系列研讨会，题为系统动力学的细胞内通信(‘空间2011’)。信息传递是生物学的一个中心方面，细胞内和细胞间的信号是多细胞生物体功能的一个基本方面。细胞间的长距离信号传递需要特定和受调控的机制来运输信号分子，并产生功能梯度来控制过程，如趋化、轴突引导、发育分化等。近年来，越来越清楚的是，细胞内的信息传输和信号传递需要同样复杂和多样化的机制。仅靠扩散不足以解释不同信号从细胞表面到细胞核的有效转移，以对抗不利的酶活性。细胞内的远距离通信需要在超过几微米的任何细胞内距离上保护或促进信号传播机制。不同的研究群体对细胞内信号和信息在细胞内传播的空间方面感兴趣，包括理论家、细胞生物学家和神经生物学家。在大型和形态复杂的细胞(如神经元和其他极化的真核细胞)内的信息传输需要专门的机制来促进信号的传播和转移。空间2011将为参与这些不同研究社区的实验者和理论家之间的交流和互动提供一个独特的平台。在2007年和2009年的空间会议(在以色列举行)上，参加的美国科学家相对较少。我们已将会场迁至中欧，以特别促进美国的参与，并正在寻求NIH的支持，以支持年轻教职员工、研究员和学生在这一日益增长的跨学科领域代表美国。 公共卫生相关性：这项申请寻求资金，以支持美国科学家参加一个独特的跨学科会议，重点是健康和疾病中的空间交流。细胞间的长距离信号传递需要特定和受调控的机制来运输信号分子，并产生功能梯度来控制过程，如趋化、轴突引导、发育分化等。大细胞内存活信号和其他信号的细胞内传播功能障碍与神经系统和免疫系统的疾病病因密切相关。