Systems dynamics of intracellular communication (Spatial 2011)

描述（由申请人提供）：此R13申请要求资金，以增加美国科学家在EMBO研讨会系列题为细胞内通信的系统动力学（“空间2011”）的参与。信息传递是生物学的一个核心方面，细胞内和细胞间的信号传导是多细胞生物体功能的一个基本方面。细胞之间长距离的信号传导需要特定的和受调节的机制来运输信号分子并产生功能梯度以控制诸如趋化性、轴突引导、发育分化等过程。近年来，越来越清楚的是，细胞内的信息传递和信号传导需要同样复杂和多样的机制。单独的扩散不足以解释不同信号从细胞表面到细胞核的有效转移，以对抗不利的酶活性。细胞内的长距离通信需要在超过几微米的任何细胞内距离上保护或促进信号传播的机制。不同的研究群体对细胞内信号和信息传播的空间方面感兴趣，包括理论家，细胞生物学家和神经生物学家。在大型和形态复杂的细胞（如神经元和其他极化的真核细胞）内的信息传递需要专门的机制来促进信号的传播和易位。空间2011将提供一个独特的平台，实验和理论家之间的沟通和互动，在这些不同的研究社区。2007年和2009年的空间会议（在以色列举行）只有相对较少的美国科学家参加。我们已经将场地搬迁到中欧，以特别促进美国的参与，并正在寻求NIH的支持，以支持美国代表年轻的教师，研究员和学生在这个不断增长的跨学科领域。 公共卫生相关性：该申请寻求资金，以支持美国科学家参加一个独特的跨学科会议，重点是健康和疾病的空间通信。细胞之间长距离的信号传导需要特定的和受调节的机制来运输信号分子并产生功能梯度以控制诸如趋化性、轴突引导、发育分化等过程。大细胞中存活和其他信号的细胞内传播功能障碍与神经和免疫系统中的疾病病因学密切相关。

DESCRIPTION (provided by applicant): This R13 application requests funds to increase participation by US scientists in an EMBO workshop series entitled Systems Dynamics of Intracellular Communication ('Spatial 2011'). Information transfer is a central aspect of biology, and signaling within and between cells is a fundamental aspect of the functioning of multicellular organisms. Signaling over long distances between cells requires specific and regulated mechanisms to transport signaling molecules and generate functional gradients to control processes such as chemotaxis, axon guidance, developmental differentiation and others. In recent years it has become increasingly clear that equally sophisticated and diverse mechanisms are required for information transfer and signaling within cells. Diffusion alone is not sufficient to account for effective transfer of different signals from cell surface to the nucleus against unfavorable enzymatic activities. Long distance communication within cells requires protected or facilitated mechanisms of signal propagation over any intracellular distance of more than a few micrometers. Different communities of researchers are interested in spatial aspects of propagation of intracellular signals and information within cells, including theoreticians, cell biologists, and neurobiologists. Information transfer within large and morphologically complex cells (such as neurons and other polarized eukaryotic cells) requires specialized mechanisms to facilitate propagation and translocation of signals. Spatial 2011 will provide a unique platform for communication and interaction between the experimentalists and theoreticians involved in these diverse research communities. The 2007 and 2009 Spatial meetings (held in Israel) saw participation from relatively few US scientists. We have relocated the venue to central Europe to specifically facilitate US participation and are seeking NIH support to support US representation by young faculty, fellows, and students in this growing interdisciplinary field. PUBLIC HEALTH RELEVANCE: This application seeks funds to support US scientists' participation in a unique interdisciplinary conference focusing on spatial communication in health and disease. Signaling over long distances between cells requires specific and regulated mechanisms to transport signaling molecules and generate functional gradients to control processes such as chemotaxis, axon guidance, developmental differentiation and others. Malfunction of intracellular propagation of survival and other signals in large cells is tightly linked with disease etiology in the nervous and immune systems.