2012 Neural Development Gordon Research Conference

描述（申请人提供）：成人中枢神经系统的正常功能需要高度协调和精确调节的发育程序来协调神经发生、神经元迁移、轴突引导和突触发生。这些程序的改变已被证明是一系列神经发育障碍的基础，包括自闭症谱系障碍、精神分裂症、智力迟钝、癫痫和神经变性。因此，全面了解神经系统发育的基本机制对于合理设计治疗这些疾病的策略至关重要。2012年神经发育戈登研究会议的目标是将现有和新兴的研究人员聚集在一起，讨论最近的研究突破，以促进互动和合作，并加强转化研究的基础。会议的总体主题将围绕分子和遗传方法，以及跨物种研究在我们理解神经发育原理中的作用。自1981年以来，该会议每两年举行一次，已成为该领域的主要会议，始终吸引着国内外杰出的研究人员，以及学生和博士后，在一个小型，互动的环境中进行深入的科学讨论。会议的形式以口头陈述为中心，然后是广泛的讨论，高度互动的海报会议，以及非正式会议的“自由”时间，这使得互动的水平和深度在其他大型会议中很少发现。2012年

DESCRIPTION (provided by applicant): The proper function of the adult central nervous system requires highly orchestrated and precisely regulated developmental programs to coordinate neurogenesis, neuronal migration, axon guidance and synaptogenesis. Alterations in these programs have been shown to underlie a wide array of neurodevelopmental disorders including autism spectrum disorders, schizophrenia, mental retardation, epilepsia and neurodegeneration. Thus, a complete understanding of the basic mechanisms of nervous system development is essential for a rational design of strategies to treat these disorders. The goal of the 2012 Neural Development Gordon Research Conference is to bring together established and rising investigators to discuss recent research breakthroughs, in order to foster interactions and collaborations, and to strengthen the foundation for translational research. The overall theme of the meeting will center around molecular and genetic approaches, and the role of cross-species investigations in our understanding of neurodevelopmental principles. This conference has been held biannually since 1981, and has become the premier conference in this field that consistently attracts prominent national and international researchers, as well as students and postdoctoral fellows in a small, interactive setting for in-depth scientific discussions. The format of the meeting which is centered around oral presentations followed by extensive discussions, highly interactive poster sessions, and 'free' time for informal meetings allows a level and depth of interaction that is rarely found at other, larger conferences. The 2012 conference will cover 8 themes including neurogenesis and brain patterning; cell fate specification; neural stem cells; neuronal migration and polarization; neuronal morphogenesis; wiring the nervous system; synaptogenesis and circuit formation; human brain evolution. In developing the program, attention was paid to inviting speakers who have made recent exciting breakthroughs and who use a variety of model systems (worm, fruit fly, xenopus, zebrafish, mouse, human) and multiple approaches including molecular, genetic and cellular, in their research. The program also includes national and international speakers, as well as both senior and junior researchers. 35% of the confirmed speakers are women. Based on prior history and the exciting list of confirmed speakers, we expect that the 2012 Neural Development GRC will be a successful forum furthering our understanding of neural development, and in promoting strategies for translational research to address human neurodevelopmental pathologies. PUBLIC HEALTH RELEVANCE: Research conferences provide a critical forum for the dissemination of research findings, and for the establishment of collaborations leading to novel insights. The 2012 Gordon Research Conference in Neural Development is expected to impact public health by furthering our understanding of the basic mechanisms by which the central and peripheral nervous systems develop, and how these mechanisms are disrupted in neurodevelopmental disorders. Discussions and interactions among researchers working on different model systems using various complementary experimental approaches is expected to result in the initiation of novel research directions, leading to the development of new therapeutic strategies and the identification of targets for rational treatment approaches.