Midwest Blood Club Symposium, 2012

描述(申请人提供)：血液是一种特殊的组织，执行几个重要的生理功能，包括携带氧气，对抗感染，和凝结伤口。血细胞功能障碍的病因多种多样，导致多种血液疾病，包括贫血、骨髓增生性疾病、白血病、感染、出血性疾病和高凝状态。尽管在血液疾病的诊断和治疗方面取得了长足的进步，但这些疾病继续导致患者显著的发病率和死亡率。此外，自体和异体干细胞移植仍然是几种先天性疾病和获得性恶性肿瘤的主要治疗方法。因此，总体而言，更好地了解正常的造血、干细胞生物学和造血疾病状态，在血液疾病、先天性疾病和癌症的预防措施和改进治疗方面，与我们在美国的国家利益相关。中西部血液俱乐部研讨会成立于2003年，是一个论坛，旨在促进中西部大学对造血学和造血干细胞生物学有共同兴趣的研究人员之间的合作关系。本次会议的目标是促进中西部地区在造血和干细胞生物学领域的区域合作，并为研究生和博士后在讲台和海报演示方面的培训提供一种共同的氛围。随着我们的前进，我们正在寻求吸引更多的内科科学家参与患者护理和基础研究，以努力强调传统上在这次会议上提出的基础科学研究的临床意义和潜在应用。通过每年一次的会议，调查人员可以利用合作同事和机构的优势，从而协同提高生产率。由于这些机构间的互动和合作，机构和外部研究资金得到了更有效的利用和杠杆作用，以获得高质量的研究成果。我们的目标是：1)为中西部地区专注于造血和造血干细胞生物学的研究人员提供一个思想对话和专业知识和服务交流的场所；2)创造一个亲切但具有挑战性的环境，以教育和培训研究生和博士后研究员介绍、解释和证明科学数据和解释的合理性；以及3)扩大会议的范围，包括更多的内科科学家，以就正在进行的基础科学研究的意义提供背景和观点，并提出以临床为基础的研究。

DESCRIPTION (provided by applicant): The blood is a specialized tissue that performs several crucial physiologic functions including carrying oxygen, fighting infections, and clotting wounds. The etiology of blood cell dysfunction is diverse and results in a myriad of blood disorders including anemia, myeloproliferative disorder, leukemia, infections, bleeding disorders, and hypercoagulable states. Despite considerable advances in the diagnosis and treatment of blood disorders, these diseases continue to cause significant patient morbidity and mortality. Additionally, autologous and allogeneic stem cell transplantation continues to be a mainstay of therapy for several congenital disorders and acquired malignancies. Thus, collectively, improved understanding of normal hematopoiesis, stem cell biology, and hematopoietic disease states is relevant to our national interest in the United States in terms of preventive measures and improved therapies for blood disorders, congenital disorders, and cancers. The Midwest Blood Club Symposium was initiated in 2003 as a forum to facilitate collaborative ties between investigators at Midwestern universities with a mutual interest in hematopoiesis and hematopoietic stem cell biology. The objectives of this meeting have been to foster regional collaborations in the area of hematopoiesis and stem cell biology within the Midwest and to provide a collegial atmosphere for the training of graduate students and post-doctoral fellows in platform and poster presentations. As we move forward, we are seeking to attract more physician scientists involved in both patient care and basic research, in an effort to underscore the clinical significance and potential application of the basic science studies traditionally presented at this meeting. By meeting on an annual basis, investigators can harness strengths of collaborating colleagues and institutions, resulting in a synergistic increase in productivity. Because of these inter-institutional interactions and collaborations, institutional and extramural research dollars are more efficiently utilized and leveraged for high quality research outcomes. We aim to 1) provide a venue for dialogue of ideas and exchange of expertise and services among investigators located in the Midwest focused on hematopoiesis and hematopoietic stem cell biology; 2) engender an amiable, yet challenging, environment to educate and train graduate students and post-doctoral fellows in the presentation, explanation, and justification of scientific data and interpretation; and 3) broaden the scope of the meeting to include more physician scientists to provide context and perspective on the significance of the ongoing basic science studies and to present clinically-based studies.