Stanford Career Development in Vascular Medicine

斯坦福血管医学职业发展

• 批准号: 8324232
• 负责人: RONALD L DALMAN
• 金额: $ 52.16万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8324232
• 关键词: Address; Arteries; Bioinformatics; Biometry; Blood Vessels; Breeding; Cardiovascular system; Caring; Cellular biology; Cessation of life; Clinical; Clinical Research; Clinical Trials Design; Computer Simulation; Data Base Management; Development; Discipline; Disease; Elements; Endocrinology; Engineering; Epidemiology; Exposure to; Faculty; Funding; Genetic; Genomics; Grant; Hematology; Hospitalization; Immunology; Institutes; Institutional Review Boards; Internist; Knowledge; Lymphatic Diseases; Manuscripts; Mechanics; Medicine; Mentors; Molecular; Molecular Biology; Morbidity - disease rate; Nephrology; Pharmacology; Physics; Physiology; Preparation; Proteomics; Public Health; Pulmonology; Regulatory Affairs; Research; Research Personnel; Research Project Grants; Technology; Tissues; Training; Training Programs; United States; Universities; Update; Vascular Diseases; Veins; Venous; Work; Writing; abstracting; career development; clinical practice; clinically relevant; cohort; design; experience; medical specialties; mortality; multidisciplinary; next generation; programs; responsible research conduct; stem cell biology

DESCRIPTION (provided by applicant): Vascular disease is the leading cause of morbidity and mortality in the United States. There is a public health need for increased transfer of knowledge between the various disciplines that constitute this research field, and accelerated application of the basic information to clinical practice. The Stanford program addresses with a multidisciplinary program and faculty performing scientific and clinical work related directly to Vascular Medicine including cardiovascular and pulmonary medicine, endocrinology, hematology, nephrology, immunology, epidemiology and clinical trials design, cell and molecular biology, developmental and stem cell biology, tissue and mechanical engineering, physics and computational modeling, genetics/genomics,proteomics, physiology and molecular pharmacology. This proposal is designed to address the educational and clinical needs in the emerging specialty of Vascular Medicine. The program will produce clinician investigators with a deep fund of knowledge regarding vascular medicine, and a high level of proficiency in clinical research. This new breed of investigators will apply cutting edge technology to clinically relevant questions in vascular medicine, and they will be able to train the next generation of vascular internists. Our Specific aims are to: 1) Develop, institute and annually evaluate a one year core clinical training program that confers competency in the management of arterial, venous and lymphatic diseases and associated disorders; 2) Formulate, initiate and annually update a didactic training program in clinical research emphasizing clinical trial design, biostatistics and bioinformatics, genomics and proteomics, regulatory affairs, and responsible conduct of research; 3) Provide a clinical research experience guided by an experienced Mentor, facilitated by a cohort of collaborative Co-mentors, and focused on a clinical research project. Other elements include exposure to trial design, interaction with and direct participation on the Institutional Review Board, database management and analysis, manuscript preparation, and grant writing. Lay description: Diseases of the arteries and veins cause most of the hospitalizations and deaths in the United States. Stanford University proposes a comprehensive educational program that will train a new breed of doctors that can recognize and treat these diseases, develop new therapies, and train young doctors in the care of people with vessel disease. (End of Abstract).

描述（由申请人提供）： 血管疾病是美国发病率和死亡率的主要原因。有一个公共卫生需要增加知识的各个学科之间的转移，构成这个研究领域，并加速应用的基本信息的临床实践。该斯坦福大学计划地址与多学科计划和教师进行直接相关的血管医学，包括心血管和肺医学，内分泌学，血液学，肾脏学，免疫学，流行病学和临床试验设计，细胞和分子生物学，发育和干细胞生物学，组织和机械工程，物理和计算建模，遗传学/基因组学，蛋白质组学，生理学和分子药理学。该提案旨在满足血管医学新兴专业的教育和临床需求。该计划将产生临床研究人员与血管医学知识的深厚基础，并在临床研究的熟练程度高。这种新一代的研究人员将把尖端技术应用于血管医学的临床相关问题，他们将能够培养下一代血管内科医生。 我们的具体目标是：1）制定，制定和每年评估一年的核心临床培训计划，赋予动脉，静脉和淋巴疾病及相关疾病的管理能力; 2）制定，启动和每年更新临床研究教学培训计划，强调临床试验设计，生物统计学和生物信息学，基因组学和蛋白质组学，法规事务，以及负责任的研究行为; 3）提供由经验丰富的导师指导的临床研究经验，由一群合作的共同导师促进，并专注于临床研究项目。其他要素包括接触试验设计，与机构审查委员会的互动和直接参与，数据库管理和分析，手稿准备和赠款写作。通俗描述：在美国，动脉和静脉疾病是导致住院和死亡的主要原因。斯坦福大学提出了一项综合教育计划，该计划将培养一批能够识别和治疗这些疾病的新一代医生，开发新的疗法，并培训年轻医生护理血管疾病患者。(End抽象）。

项目成果

Clinical trials of adult stem cell therapy for peripheral artery disease.

成体干细胞治疗外周动脉疾病的临床试验。

• DOI: 10.14797/mdcj-9-4-201
• 发表时间: 2013
• 期刊: Methodist DeBakey cardiovascular journal
• 作者: Botham,CrystalM;Bennett,WilliamL;Cooke,JohnP
• 通讯作者: Cooke,JohnP

Assessing endothelial vasodilator function with the Endo-PAT 2000.

• DOI: 10.3791/2167
• 发表时间: 2010-10-15
• 期刊: Journal of visualized experiments : JoVE
• 作者: Axtell, Andrea L;Gomari, Fatemeh A;Cooke, John P
• 通讯作者: Cooke, John P

The genome sequence of the colonial chordate, Botryllus schlosseri.

• DOI: 10.7554/elife.00569
• 发表时间: 2013-07-02
• 期刊: eLife
• 影响因子: 7.7
• 作者: Voskoboynik A;Neff NF;Sahoo D;Newman AM;Pushkarev D;Koh W;Passarelli B;Fan HC;Mantalas GL;Palmeri KJ;Ishizuka KJ;Gissi C;Griggio F;Ben-Shlomo R;Corey DM;Penland L;White RA 3rd;Weissman IL;Quake SR
• 通讯作者: Quake SR

Endothelial cells derived from human iPSCS increase capillary density and improve perfusion in a mouse model of peripheral arterial disease.

• DOI: 10.1161/atvbaha.111.230938
• 发表时间: 2011-11
• 期刊: Arteriosclerosis, thrombosis, and vascular biology
• 作者: Rufaihah AJ;Huang NF;Jamé S;Lee JC;Nguyen HN;Byers B;De A;Okogbaa J;Rollins M;Reijo-Pera R;Gambhir SS;Cooke JP
• 通讯作者: Cooke JP

Lansoprazole worsens asthma control in poor metabolizers: is nitric oxide involved?

兰索拉唑会恶化代谢不良者的哮喘控制：是否涉及一氧化氮？

• DOI: 10.1513/annalsats.201504-238le
• 发表时间: 2015
• 期刊: Annals of the American Thoracic Society
• 影响因子: 8.3
• 作者: Sukhovershin,RomanA;Ghebremariam,YohannesT;Cooke,JohnP
• 通讯作者: Cooke,JohnP