Transplant Associated Infection Surveillance Network Phase II

描述（由申请人提供）：移植后感染是实体器官移植受者和造血干细胞移植受者发病和死亡的主要原因。在过去的6年里，我们已经完成了一个前瞻性的23个中心监测网络（TRANSNET），筛选了34,000多名移植受者，并确定了2100多例确诊和可能的侵袭性真菌感染（IFI）病例。这些数据提高了对美国疾病负担的了解，并突出了移植组之间的一些主要差异。尽管TRANSNET作为一种衡量疾病负担的方法很有价值，但它对重要风险因素进行病例对照试验的能力有限。美国疾病控制与预防中心发起的器官移植感染检测和预防计划（2004-2009）是及时和必要的下一步，以评估与ifl发展相关的危险因素，并开始对重要的非真菌病原体进行前瞻性监测。我们在这个项目中的成功可以通过从3个地点将大量患者纳入2个队列（肺移植受体和同种异体干细胞移植受体）来衡量，并且在这两个高风险组中观察到不同类型的感染。在本提案中，我们建议实现以下目标：1)在美国3个移植中心（阿拉巴马大学伯明翰分校，密歇根大学和宾夕法尼亚大学）对选定的otr和hsct进行前瞻性监测，以确定和可能的ifl；2)在侵袭性霉菌感染高危患者中开展病例对照研究，确定重要的院内和门诊危险因素，并提出预防建议；3)制定对选定的非真菌病原体（如艰难梭菌、巨细胞病毒、西尼罗河病毒、呼吸道病毒和选定的多重耐药细菌）进行前瞻性监测的方法；4)建立真菌分离株和其他临床标本库。这些目标的实现将为了解与ifl发展和其他移植后感染并发症相关的关键可改变风险因素提供至关重要的见解，特别是在高危患者中。此外，在多个地点建立标准监测方法将显著提高重要病原体数据收集的质量和便利性。最后，建立一个数据库对于开发和验证新的诊断分析方法将是非常宝贵的。

DESCRIPTION (provided by applicant): Infections in the post-transplant period are a leading cause of morbidity and mortality among solid organ transplant recipients and hematopoietic stem cell transplant recipients. In the last 6 years we have completed a prospective 23 center surveillance network (TRANSNET), screening over 34,000 transplant recipients and identifying over 2100 proven and probable cases of invasive fungal infection (IFI). These data have led to improved understanding of the disease burden in the U.S. and has highlighted some of the major differences among transplant groups. Despite its value as a measure of disease burden, TRANSNET had limited ability to perform case-control trials of important risk factors. The CDC- sponsored initiative Organ Transplant Infection Detection and Prevention Program (2004-2009) was a timely and necessary next step toward the assessment of risk factors associated with the development of IFls, and to initiate prospective surveillance for important non-fungal pathogens. Our success in this program can be measured by the large numbers of patients enrolled into 2 cohorts (lung transplant recipients and allogeneic stem cell transplant recipients) from 3 sites, and the diverse types of infection observed among each of these two high risk groups. In this proposal, we propose to achieve the following aims: 1) to perform prospective surveillance among selected OTRs and HSCTs for proven and probable IFls at 3 US transplant centers (University of Alabama at Birmingham, University of Michigan, and University of Pennsylvania); 2) to perform case-control studies among patients at high risk for invasive mould infections to identify significant nosocomial and outpatient risk factors and to establish recommendations for prevention; 3) to develop methodologies for conducting prospective surveillance for selected non-fungal pathogens (i.e. C.difficile, cytomegalovirus, West Nile virus, respiratory viruses, and selected multiresistant bacteria); and 4) to establish a bank for fungal isolates and other clinical specimens. The achievement of these goals will provide critically important insights into the key modifiable risk factors associated with the development of IFls and other post-transplantation infectious complications in especially high-risk patients. Moreover, the establishment of standard surveillance methodology across multiple sites will significantly improve the quality and ease of data collection for important pathogens. Finally, the establishment of a bank will be invaluable in the development and validation of newer diagnostic assays. PUBLIC HEALTH RELEVANCE: Organ and hematopoietic stem cell transplantation has become an increasingly important and life saving measure for thousands of persons each year in the United States. Organ rejection, graft vs. host disease, and post-transplantation infections complications, especially invasive fungal infection, are the key factors related to morbidity and mortality in this population. Important questions remain concerning invasive fungal infections in transplant recipients, including determining the real burden of disease and identifying key risk factors associated with development of these complications. Moreover, the emergence of new non-fungal pathogens, especially C. difficile colitis, West Nile virus, other respiratory viruses, and multiresistant bacteria, dictates renewed focus on the post-transplant period. Thus, the Organ Transplant Infection Detection and Prevention Program (OTIP) is a timely and important initiative put forth by the CDC to address some of the more important issues in these patients. This application involves three large, well-integrated transplant programs (University of Alabama at Birmingham, University of Michigan and University of Pennsylvania) with strong experience in prospective surveillance and excellent record of collaboration. This consortium is very well positioned to accomplish the goals set forth in this announcement.