Electrochemical Catheter for Prevention of Central Line-Associated Bloodstream Infection
用于预防中心静脉导管相关血流感染的电化学导管
基本信息
- 批准号:10560927
- 负责人:
- 金额:$ 39.54万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-02-20 至 2027-01-31
- 项目状态:未结题
- 来源:
- 关键词:Acinetobacter baumanniiAddressAnimal ModelAnimal TestingAnimalsAntibioticsBacteriaBacterial Drug ResistanceBiocideBlood CellsBlood CirculationCOVID-19 pandemicCOVID-19 patientCandidaCandida albicansCandida aurisCaringCathetersClinicalCritical IllnessCustomDevicesDrug resistanceEnterobacter cloacaeEnterococcus faeciumEscherichia coliExperimental Animal ModelFunctional disorderGenerationsHealthcareHemodialysisHourHumanHypochlorous AcidIn VitroInfectionInfection preventionKlebsiella pneumoniaeLaboratoriesLength of StayLifeLiquid substanceLocal Anti-Infective AgentsMicrobial BiofilmsModelingOryctolagus cuniculusParenteral NutritionPatientsPharmaceutical PreparationsPreventionPrevention approachPrevention strategyPseudomonas aeruginosaReactionReportingRouteSepsisSiteSourceStaphylococcus aureusStaphylococcus epidermidisSurfaceSystemTechniquesTestingToxic effectVascular Endothelial CellVenousWorkYeastsantimicrobialantimicrobial drugbreakthrough infectioncatheter related infectioncell growthcommensal microbesdesignemerging antibiotic resistancein vitro Modelinfection rateinnovationmedication administrationmicrobialmicrobial colonizationmicroorganismmortalitynovelpathogenpressureprevent
项目摘要
PROJECT SUMMARY
Central venous catheters are indispensable healthcare devices used for a range of applications from
hemodialysis to critically ill patients. Unfortunately, central venous catheters provide a route for entry of
pathogens into the bloodstream, resulting in central line-associated bloodstream infection (CLABSI). The
pathophysiology of CLABSI comprises two main routes of infection: the extraluminal route for short-term central
venous catheters, where microorganisms enter from the insertion site and colonize the catheter tip; and the
intraluminal route for long-term central venous catheters, where frequent line manipulation introduces
microorganisms into the lumen. While many approaches for CLABSI prevention focus on aseptic techniques to
mitigate extraluminal and, to some extent, intraluminal infections, intraluminal infections remain a major source
of CLABSI. Here, we propose to develop a non-antibiotic approach to prevent CLABSI using controlled
electrochemical reactions occurring in the catheter lumen to generate the biocide hypochlorous acid (HOCl). In
preliminary work, we showed antimicrobial activity of electrochemical HOCl generation on catheter surfaces, and
in a preliminary in vitro catheter model, demonstrated that this strategy may prevent CLABSI. We further showed
that HOCl concentrations and delivery rates are controllable by tuning electrochemical parameters. We term the
devices we propose to develop that will generate intraluminal HOCl as a CLABSI prevention strategy,
electrochemical intravascular catheters (e-catheters). eCatheters will use a novel intraluminal electrochemical
system designed to deliver HOCl at concentrations ‘tuned” to prevent microbial cell growth and biofilm formation
without causing host toxicity. The e-catheters will be controlled by custom-designed micropotentiostats for use
in animals (and, eventually, in humans). The developed devices will be tested against 12 species of bacteria and
yeast in vitro and evaluated in a rabbit model of intravascular catheter-associated infection to assess prevention
of Staphylococcus aureus and Klebsiella pneumoniae CLABSI. The innovative e-catheter strategy provides an
original way to address CLABSI prevention, avoiding conventional antibiotics and therefore selective pressure
on commensal microbiota and emergence of antibiotic resistance.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Haluk Beyenal其他文献
Haluk Beyenal的其他文献
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Novel Electrochemical Bandage for Treatment of Wound Infections
用于治疗伤口感染的新型电化学绷带
- 批准号:
10415180 - 财政年份:2011
- 资助金额:
$ 39.54万 - 项目类别:
Novel Electrochemical Bandage for Treatment of Wound Infections
用于治疗伤口感染的新型电化学绷带
- 批准号:
10163118 - 财政年份:2011
- 资助金额:
$ 39.54万 - 项目类别:
Novel Electrochemical Bandage for Treatment of Wound Infections
用于治疗伤口感染的新型电化学绷带
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9817211 - 财政年份:2011
- 资助金额:
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