The Protein Structure Inittiative Knowledgebase

描述（由申请人提供）：蛋白质结构倡议（PSI）知识库。我们建议创建一个信息库和门户网站，称为结构生物学知识库（SBKB），这将是当前结构基因组学知识库（SGKB）的增强版本。SBKB将整合PSI的产品：生物学中心与来自外部数据库和社区输入的数据，以提供有关结构基因组学目标跟踪数据库TargetDB和蛋白质结构库Protein Data Bank中所有蛋白质序列的全面序列，结构和功能信息。此外，我们将继续与自然出版集团合作，为结构生物学和基因组学的所有信息提供一个“门户”。 SGKB将PSI工作的产品组织成七个模块（实验数据跟踪、技术、材料、建模、注释、出版物和数据库），以便所有生物学和生物医学研究人员可以从中央“一站式商店”访问这些信息。在这个建议中，我们描述了我们的计划，以加强现有的模块，并提出了一个新的格式来组织基本SBKB数据到四个分类视图：目标，方法，结构-序列-功能，和模型枢纽。这种方法通过向用户提供信息的集中视图来改进当前的单一界面方法。我们还在开发一个数据可视化工具，允许用户动态探索SBKB数据中的关系，以创建新的假设。 科技咨询机构将在协调整个防扩散安全倡议：生物学网络的活动以及在与不同生物学领域的联系方面发挥重要作用。现有系统将用于协调PSI：生物学网络参与者的内部通信。为了增加社区的参与，我们描述了最近的增强社区提名的目标系统，并提出了一个新的网络工具，收集社区注释的结构和目标，使合作。我们的目标是使SBKB成为所有生物和生物医学社区的参与和广泛使用的资源。 公共卫生相关性：结构生物学知识库将促进和简化来自各种生物学科的用户对蛋白质序列、结构和功能信息的访问。通过这种方式，将有可能获得生物学和疾病的分子基础的广泛和深入的理解。

DESCRIPTION (provided by applicant): Protein Structure Initiative (PSI) Knowledgebase. We propose to create an Information repository and web portal called the Structural Biology Knowledgebase (SBKB), which will be an enhanced version of the current Structural Genomics Knowledgebase (SGKB). The SBKB will integrate the products of the PSI:Biology centers with data from external databases and community input to provide comprehensive sequence, structural, and functional information about all protein sequences In the structural genomics target tracking database, TargetDB, and the protein structure repository, the Protein Data Bank. In addition, we will continue to collaborate with the Nature Publishing Group to provide a "Gateway" to all information about structural biology and genomics. The SGKB has organized the products of the PSI efforts into seven modules (Experimental Data Tracking, Technology, Materials, Modeling, Annotation, Publications, and Metrics) so that all biological and biomedical researchers can access this information from a central "one-stop shop". In this proposal, we describe our plan to enhance the existing modules, and propose a new format to organize the underlying SBKB data into four categorical views: the Targets, Methods, Structure-Sequence-Function, and Models Hubs. This approach improves upon the current single-interface method by providing users with focused views of the information. We are also in the process of developing a data visualization tool that allows users to dynamically explore relationships in the SBKB data to enable the creation of new hypotheses. The SBKB will play an important role in the coordination of activities across the PSI:Biology Network and in outreach to diverse biological fields. Existing systems will be used to coordinate internal communications for PSI:Biology Network participants. In order to increase community involvement, we describe an recent enhancement to the community-nominated targets system, and propose a new web tool that collects community annotations for structures and targets and enables collaborations. Our goal is for the SBKB to become an engaging and widely-used resource for all biological and biomedical communities. PUBLIC HEALTH RELEVANCE: The Structural Biology Knowledgebase will facilitate and simplify access to protein sequence, structure, and functional information for users from a variety of biological disciplines. In this way, it will be possible to gain both a broad and deep understanding of the molecular basis of biology and disease.