DEVELOPING A PUBLIC CRYOEM REPOSITORY DATABASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在过去的十年中，使用电子低温显微镜确定的结构数量有了显着的增长，预计这一趋势将加速。为了提供一个适当的接口，用于描述和存档cryoEM结构，我们与PDB和EBI在开发cryoEM本体描述不仅结构本身，而且实验条件和相关的元数据项。我们希望建立一个社区共识的数据项所需的沉积三维密度图和原子模型来自cryoEM研究。此外，我们专注于改善目前的cryoEM数据收集和沉积方法，使实验人员将有一个共同的，易于使用的，一站式门户cryoEM结构沉积。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The past decade has seen a remarkable growth in the number of structures determined using electron cryomicroscopy; this trend is expected to accelerate. In order to provide a proper interface for describing and archiving cryoEM structures, we work with PDB and EBI in developing a cryoEM ontology to describe not only the structure itself, but also experimental conditions and pertinent meta-data items. We look to establishing a community consensus on the data items needed for deposition of 3D density maps and atomic models derived from cryoEM studies. Additionally, we are focused on improving the current cryoEM data collection and deposition methods so that the experimentalists will have a common, easy to use, one-stop portal for cryoEM structure deposition.