East Carolina University Bariatric Surgery Clinical Center

东卡罗莱纳大学减肥外科临床中心

• 批准号: 8119120
• 负责人: WALTER Julius PORIES
• 金额: $ 50.95万
• 依托单位: EAST CAROLINA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8119120
• 关键词: Achievement; Address; African American; Age; Characteristics; Clinical; Community Hospitals; Data; Enrollment; Genetic Markers; Hispanics; Individual; Link; Metabolism; Metric; Obesity; Operative Surgical Procedures; Outcome; Participant; Patients; Population; Process; Recruitment Activity; Research Infrastructure; Serological; Site; Subgroup; Surgeon; System; Universities; Vital Status; bariatric surgery; care delivery; clinical care; clinical research site; cohort; economic outcome; follow-up; health economics; male; operation; patient population; psychosocial

DESCRIPTION (provided by applicant): LABS was conceived to address important issues in bariatric surgery and metabolism in the obese and morbidly obese. LABS aims to explore relationships of patient characteristics, clinical conditions, serologic and genetic markers, process of care, and clinical, psychosocial and health economic outcomes. The primary achievements of LABS in its first 5 years have been to define the domains of exploration, identify appropriate metrics and enroll 5105 participants in LABS land achieve vital status data for 99% due for at 30 days post-surgery. In addition, 1947 participants in LABS 2 have been recruited with data collected for 91% for 6 months follow-up. An extension of LABS would build on the rigorous research infrastructure across 10 clinical sites at the 6 clinical centers representing several care delivery systems and patient populations. LABS enrolls patients from 6 academic and 4 community hospitals undergoing operations by 33 surgeons. These sites have created a cohort with considerable diversity of important patient characteristics. LABS includes 21% males (range across sites 16% to 32%), 9% Black/African-Americans (range 0% to 24%), 7% Hispanics (range 1% to 16%), 10% age 60+ years (range 5%-18%), and 10% BMI 60+ kg/m2 (range 6% to 27%). These features have been linked to short and long-term outcomes and represent critical subgroups that have not been adequately characterized because they appear infrequently in most single-center cohorts. Importantly, the diversity across sites is more likely to represent the bariatric surgery population in the U.S. than would be possible from any individual site.

描述（由申请人提供）： LABS旨在解决肥胖和病态肥胖患者的减肥手术和代谢中的重要问题。LABS旨在探索患者特征、临床状况、血清学和遗传标志物、护理过程以及临床、心理社会和卫生经济结果之间的关系。LABS在其前5年的主要成就是定义了探索领域，确定了适当的指标，并在LABS中招募了5105名参与者，并在术后30天获得了99%的生命状态数据。此外，招募了1947名LABS 2参与者，收集了91%的6个月随访数据。 实验室的扩展将建立在6个临床中心的10个临床研究中心的严格研究基础设施上，代表几个医疗服务系统和患者人群。实验室招募了来自6所学术医院和4所社区医院的患者，这些患者接受了33名外科医生的手术。这些研究中心创建了一个具有相当多的重要患者特征的队列。LABS包括21%的男性（研究中心范围为16%-32%）、9%的黑人/非洲裔美国人（范围为0%-24%）、7%的西班牙裔美国人（范围为1%-16%）、10%的年龄60岁以上（范围为5%-18%）和10%的BMI 60+ kg/m2（范围为6%-27%）。这些特征与短期和长期结局相关，代表了尚未充分表征的关键亚组，因为它们在大多数单中心队列中很少出现。重要的是，各研究中心的多样性更有可能代表美国的减肥手术人群，而不是任何单个研究中心。