East Carolina University Bariatric Surgery Clinical Center

东卡罗莱纳大学减肥外科临床中心

• 批准号: 8727921
• 负责人: WALTER Julius PORIES
• 金额: $ 16万
• 依托单位: EAST CAROLINA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8727921
• 关键词: Achievement; Address; African American; Age; Characteristics; Clinical; Community Hospitals; Data; Data Collection; Data Element; Databases; Enrollment; Genetic Markers; Hispanics; Individual; Instruction; Link; Metabolism; Metric; Obesity; Operative Surgical Procedures; Outcome; Participant; Patients; Population; Process; Recruitment Activity; Research Infrastructure; Serological; Site; Subgroup; Surgeon; System; Time; Universities; Vital Status; bariatric surgery; care delivery; clinical care; clinical research site; cohort; economic outcome; follow-up; health economics; male; operation; patient population; psychosocial

LABS was conceived to address important issues in bariatric surgery and metabolism in the obese and morbidly obese. LABS aims to explore relationships of patient characteristics, clinical conditions, serologic and genetic markers, process of care, and clinical, psychosocial and health economic outcomes. The primary achievements of LABS in its first 5 years have been to define the domains of exploration, identify appropriate metrics and enroll 5105 participants in LABS land achieve vital status data for 99% due for at 30 days post-surgery. In addition, 1947 participants in LABS 2 have been recruited with data collected for 91% for 6 months follow-up. An extension of LABS would build on the rigorous research infrastructure across 10 clinical sites at the 6 clinical centers representing several care delivery systems and patient populations. LABS enrolls patients from 6 academic and 4 community hospitals undergoing operations by 33 surgeons. These sites have created a cohort with considerable diversity of important patient characteristics. LABS includes 21% males (range across sites 16% to 32%), 9% Black/African-Americans (range 0% to 24%), 7% Hispanics (range 1% to 16%), 10% age 60+ years (range 5%-18%), and 10% BMI 60+ kg/m2 (range 6% to 27%). These features have been linked to short and long-term outcomes and represent critical subgroups that have not been adequately characterized because they appear infrequently in most single-center cohorts. Importantly, the diversity across sites is more likely to represent the bariatric surgery population in the U.S. than would be possible from any individual site. RELEVANCE (See Instructions): Critical scientific advantages of the multi-center LABS consortium compared to single-center studies include: 1) The ability to recruit a larger number of patients, in a comparable, or shorter, period of time and 2) A research infrastructure with rigorous data collection practices, high levels of data accuracy and completeness, rigorous follow-up, and a comprehensive database of clearly defined data elements.

实验室旨在解决肥胖和肥胖人群的减肥手术和新陈代谢方面的重要问题