Off-the-shelf Dental Regeneration Technologies

现成的牙齿再生技术

• 批准号: 8252273
• 负责人: Jeremy Mao
• 金额: $ 66.5万
• 依托单位: INNOVATIVE ELEMENTS, LLC
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-09 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8252273
• 关键词: Academic Medical Centers; Acute; Affect; Age; Alkaline Phosphatase; American; Amputation; Animal Model; Animals; Apical; BMP2 gene; Businesses; Cells; Centers for Disease Control and Prevention (U.S.); Common Cold; Composite Resins; Cues; Data; Dental; Dental Care; Dental Cementum; Dental Enamel; Dental Instruments; Dental Pulp; Dental caries; Dentin; Dentin Formation; Dentists; Dose; Drug Formulations; Elements; Endodontics; Enzyme-Linked Immunosorbent Assay; Excision; Face; Filler; Flow Cytometry; Foundations; Funding; Goals; Grant; Incubators; Infection; Kinetics; Laboratories; Lead; Life; Measures; Natural regeneration; Odontoblasts; Odontogenesis; Outcome Measure; Pain; Patients; Phase; Plant Roots; Private Sector; Process; Pulp Canals; Randomized Clinical Trials; Randomized Controlled Clinical Trials; Research Infrastructure; Services; Shipping; Ships; Side; Small Business Innovation Research Grant; Source; Staging; Stem cells; Structure; Systemic infection; Technology; Testing; Time; Tissues; Tooth Crowns; Tooth Fractures; Tooth Loss; Tooth structure; Toothache; Trauma; United States; Universities; Visit; Work; alveolar bone; commercialization; controlled release; cytokine; deciduous tooth; design; experience; human disease; immunocytochemistry; in vivo; innovation; mineralization; pathogen; periapical; permanent tooth; pre-clinical; preclinical study; product development; research study; scaffold; secondary infection; stem

DESCRIPTION (provided by applicant): Dentin forms the bulk of the tooth and is covered by enamel in the crown of the tooth and cementum in the root. When dental caries breaks down enamel and involves the dentin, the patient experiences pain and thermal sensitivity. The acute phase of dental pulp infection is typically associated with excruciating pain, and if not properly managed, can lead to peri-apical infection, tooth loss, facial infection and even systemic infections such as endocardiomyotis. Current dental treatments for tooth decay rely on surgical removal of decayed enamel and dentin by dental instruments and filling of the prepared cavity with artificial materials including amalgam and composite resin. However, current restorative dental treatments by artificial fillers have finite service life and can fail unpredictably. Tooth fracture and secondary infections are among some of the well documented complications of current dental and endodontic treatments. Treatment options are further limited for deciduous teeth and young permanent teeth. We have discovered that dentin-like tissues can regenerate by bioactive scaffold formulations in our SBIR Phase I related work. The overall goal of this SBIR/Phase-2 proposal is to identify and prepare efficacious and safe bioactive scaffold formulations for the regeneration of dentin-like tissues. This SBIR-Phase 2 represents essential intermediate funding to advance our technologies to the next stage of commercialization and eventually into a product that can ultimately regenerate dentin in patients who suffer from dental pain, trauma and infections. PUBLIC HEALTH RELEVANCE: Dental caries breaks down enamel and dentin, causing pain and infections. Current dental treatments for tooth decay rely on surgical removal of decayed enamel and dentin and filling of the prepared cavity with artificial materials. We have designed a technology to regenerate dentin-like structures that may be ultimately applicable to patients who suffer from dental pain, trauma and infections.

描述（由申请人提供）：牙本质形成牙齿的主体，并在牙冠中被釉质覆盖，在牙根中被牙骨质覆盖。当龋齿破坏牙釉质并累及牙本质时，患者会感到疼痛和热敏感。牙髓感染的急性期通常与剧痛有关，如果处理不当，可导致根尖周感染、牙齿脱落、面部感染甚至全身感染，如心内膜炎。目前的蛀牙牙科治疗依赖于通过牙科器械手术去除腐烂的牙釉质和牙本质，并用包括汞合金和复合树脂的人造材料填充制备的牙洞。然而，目前通过人工填充物进行的修复性牙科治疗具有有限的使用寿命，并且可能无法预测地失败。牙齿断裂和继发感染是目前牙科和牙髓治疗的一些有据可查的并发症。乳牙和年轻恒牙的治疗选择进一步受到限制。我们在SBIR I期相关工作中发现，生物活性支架制剂可以使牙本质样组织再生。该SBIR/Phase-2提案的总体目标是鉴定和制备用于牙本质样组织再生的有效且安全的生物活性支架制剂。这项SBIR-Phase 2代表了必要的中间资金，以将我们的技术推进到下一阶段的商业化，并最终成为一种产品，最终可以使患有牙痛，创伤和感染的患者再生牙本质。 公共卫生相关性：龋齿破坏牙釉质和牙本质，引起疼痛和感染。目前的蛀牙牙科治疗依赖于手术去除腐烂的牙釉质和牙本质，并用人造材料填充准备好的洞。我们设计了一种技术来再生牙本质样结构，最终可能适用于患有牙痛，创伤和感染的患者。