Off-the-shelf Dental Regeneration Technologies

描述（由申请人提供）：牙本质构成牙齿的主体，由牙冠的牙釉质和牙根的牙骨质覆盖。当龋齿破坏牙釉质并累及牙本质时，患者就会感到疼痛和热敏。牙髓感染的急性期通常伴有剧烈疼痛，如果处理不当，可导致根尖周围感染、牙齿脱落、面部感染甚至全身感染，如心内膜炎。目前的蛀牙治疗依赖于用牙科器械手术切除腐烂的牙釉质和牙本质，并用包括汞合金和复合树脂在内的人工材料填充预备好的牙洞。然而，目前使用人工填充物进行牙齿修复治疗的使用寿命有限，并且可能出现不可预测的故障。牙齿断裂和继发感染是目前牙科和牙髓治疗的一些有充分记录的并发症。乳牙和幼小的恒牙的治疗选择也很有限。在我们的SBIR一期相关工作中，我们发现牙本质样组织可以通过生物活性支架配方再生。本SBIR/第二阶段提案的总体目标是鉴定和制备有效且安全的生物活性支架配方，用于牙本质样组织的再生。这项sbir - 2期研究代表了将我们的技术推进到下一个商业化阶段的必要中间资金，并最终成为一种产品，最终可以为遭受牙齿疼痛、创伤和感染的患者再生牙本质。

DESCRIPTION (provided by applicant): Dentin forms the bulk of the tooth and is covered by enamel in the crown of the tooth and cementum in the root. When dental caries breaks down enamel and involves the dentin, the patient experiences pain and thermal sensitivity. The acute phase of dental pulp infection is typically associated with excruciating pain, and if not properly managed, can lead to peri-apical infection, tooth loss, facial infection and even systemic infections such as endocardiomyotis. Current dental treatments for tooth decay rely on surgical removal of decayed enamel and dentin by dental instruments and filling of the prepared cavity with artificial materials including amalgam and composite resin. However, current restorative dental treatments by artificial fillers have finite service life and can fail unpredictably. Tooth fracture and secondary infections are among some of the well documented complications of current dental and endodontic treatments. Treatment options are further limited for deciduous teeth and young permanent teeth. We have discovered that dentin-like tissues can regenerate by bioactive scaffold formulations in our SBIR Phase I related work. The overall goal of this SBIR/Phase-2 proposal is to identify and prepare efficacious and safe bioactive scaffold formulations for the regeneration of dentin-like tissues. This SBIR-Phase 2 represents essential intermediate funding to advance our technologies to the next stage of commercialization and eventually into a product that can ultimately regenerate dentin in patients who suffer from dental pain, trauma and infections. PUBLIC HEALTH RELEVANCE: Dental caries breaks down enamel and dentin, causing pain and infections. Current dental treatments for tooth decay rely on surgical removal of decayed enamel and dentin and filling of the prepared cavity with artificial materials. We have designed a technology to regenerate dentin-like structures that may be ultimately applicable to patients who suffer from dental pain, trauma and infections.