Oxytocin regulation of social buffering following stress

催产素对压力后社会缓冲的调节

• 批准号: 8324842
• 负责人: Adam Steven Smith
• 金额: $ 3.69万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-03 至 2013-08-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8324842
• 关键词: Adrenal Glands; Amygdaloid structure; Animal Model; Anti-Anxiety Agents; Anxiety; Area; Attenuated; Behavior; Behavioral; Biological Factors; Biological Models; Blood; Blood Pressure; Brain; Brain region; Breeding; Buffers; Cells; Cessation of life; Characteristics; Child; Corticosterone; Corticotropin; Corticotropin-Releasing Hormone; Data; Development; Divorce; Dose; Enzyme Immunoassay; Event; FOS gene; Female; Fluorescence; Glucocorticoids; Heart Rate; Human; Hydrocortisone; Immunohistochemistry; Individual; Label; Laboratories; Left; Life; Measures; Mediating; Mental Health; Mental disorders; Microdialysis; Microinjections; Microtus; Neurobiology; Neurons; Neuropeptides; Neurosecretory Systems; Neurotransmitters; Nucleus Accumbens; Occupations; Oxytocin; Oxytocin Receptor; Pair Bond; Panic Disorder; Patients; Phenotype; Pituitary Gland; Plasma; Process; Radioimmunoassay; Recovery; Regulation; Research; Risk; Rodent; Role; Sampling; Social Behavior; Social Interaction; Social support; Source; Spouses; Stress; Stressful Event; System; Testing; Therapeutic; Woman; Work; biobehavior; biological adaptation to stress; brain behavior; cohort; experience; hypothalamic-pituitary-adrenal axis; male; paraventricular nucleus; physical conditioning; prairie vole; preference; programs; psychological distress; putamen; response; restraint stress; social; stress management; stressor

DESCRIPTION (provided by applicant): Social support following a stressful life event can attenuate stress response systems, such as the activation of the hypothalamic-pituitary-adrenal (HPA) axis, and reduce the odds of psychological distress or a panic disorder; this is known as social buffering. This is particularly true when support is derived from a social partner (e.g., spouse). However, biological factors that are involved with social support and their influence on the HPA axis following a stressful event are understudied due to the lack of appropriate animal models that can examine support from a social partner. The pair-bonding behavior in monogamous prairie voles (Microtus ochrogaster) is well characterized and represents a unique model system to study brain-behavior relationships. This proposal will use prairie voles as a model system to identify neuroendocrine mechanisms of social support following a stressful experience, particularly the mediating effects of the neuropeptide oxytocin (OT). The prairie vole is a highly social, monogamous rodent that breeds readily in captivity and forms a long-term social preference for their partner, a traditional characteristic of pair-bond formation. Like humans, contact with a social partner can attenuate the behavioral and HPA axis response to a stressful event. In addition, positive social interactions promote brain OT release in prairie voles, and OT release in the hypothalamic paraventricular nucleus (PVN) - which also contains corticotropin-releasing hormone neurons that project to the pituitary to control adrenocorticotropic hormone secretion and subsequent adrenal glucocorticoid release - attenuates stress reactivity. Therefore, prairie voles may serve as a unique model system to study the anxiolytic effects of interaction with a social partner following a stressful event and the potentially mediating role of OT. By using prairie voles in a social buffering stress paradigm, the results from this proposal should: (1) characterize the anxiolytic effects of interactions with a social partner and OT following a stressful event, (2) identify the role that OT has in the social buffering of the biobehavioral stress response, and (3) present neuronal phenotypes in several brain regions that are influenced by social interaction-induced OT release following a stressful experience. This research program represents several steps in examining the neurobiology mechanism underlying the social buffering effect in prairie voles.

描述（由申请人提供）：压力生活事件后的社会支持可以减弱压力反应系统，例如下丘脑-垂体-肾上腺（HPA）轴的激活，并减少心理困扰或恐慌症的几率;这被称为社会缓冲。当支持来自社会伙伴（例如，配偶）。然而，由于缺乏适当的动物模型，可以检查支持的社会合作伙伴，社会支持和HPA轴的压力事件后，他们的影响所涉及的生物因素是研究不足。一夫一妻制草原田鼠（Microtus ochrogaster）的配对联结行为被很好地描述，并代表了研究脑-行为关系的独特模型系统。这项建议将使用草原田鼠作为一个模型系统，以确定神经内分泌机制的社会支持后的压力的经验，特别是神经肽催产素（OT）的介导作用。草原田鼠是一种高度社会化的、一夫一妻制的啮齿动物，在圈养条件下很容易繁殖，并对伴侣形成长期的社会偏好，这是配对关系形成的传统特征。与人类一样，与社会伙伴接触可以减弱行为和HPA轴对压力事件的反应。此外，积极的社会互动促进草原田鼠大脑OT释放，下丘脑室旁核（PVN）中的OT释放-也包含促肾上腺皮质激素释放激素神经元，投射到垂体以控制促肾上腺皮质激素分泌和随后的肾上腺糖皮质激素释放-减弱应激反应。因此，草原田鼠可以作为一个独特的模型系统，研究焦虑的影响与社会合作伙伴的互动后，压力事件和潜在的中介作用OT。通过在社会缓冲压力范例中使用草原田鼠，该提议的结果应该：（1）描述压力事件后与社会伙伴和OT互动的抗焦虑作用，（2）确定OT在生物行为压力反应的社会缓冲中的作用，以及（3）在压力经历后受社会互动诱导的OT释放影响的几个脑区域中呈现神经元表型。这项研究计划代表了几个步骤，在检查草原田鼠的社会缓冲效应的神经生物学机制。