Structural and functional connectivity of the social decision-making network

社会决策网络的结构和功能连通性

• 批准号: 10398026
• 负责人: Adam Steven Smith
• 金额: $ 36.67万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10398026
• 关键词: Address; Affect; Aggressive behavior; Agonist; Animal Model; Animals; Anterior Hypothalamus; Area; Behavior; Behavioral; Brain; Brain region; Breeding; Calcium; Cannulas; Cholera Toxin Protomer B; Complex; Corticotropin-Releasing Hormone; Data; Decision Making; Exposure to; FOS gene; Family; Female; Fiber; Fostering; Friends; Globus Pallidus; Goals; Grooming; Human; Implant; Individual; Internal Ribosome Entry Site; Intervention; Lateral; Measurement; Measures; Microtus; Midbrain structure; Modeling; Molecular and Cellular Biology; Neurons; Nucleus Accumbens; Pair Bond; Pattern; Pharmaceutical Preparations; Photometry; Population; Process; Prosencephalon; Proteins; Research; Resolution; Rewards; Rodent; Role; Series; Serotonin; Services; Shapes; Signal Transduction; Social Behavior; Social Environment; Social Interaction; Stimulus; Structure; System; Techniques; Technology; Testing; Time; Tracer; Vasopressins; Ventral Tegmental Area; Virus; Visualization; affiliative behavior; antagonist; base; behavioral response; calcium indicator; cellular imaging; cohort; fluorophore; hormonal signals; in vivo; innovation; male; neural circuit; neural network; neurochemistry; neurogenetics; neuromechanism; new technology; optical fiber; prairie vole; receptor; relating to nervous system; response; single bond; social; social engagement; social relationships; temporal measurement; tool

PROJECT SUMMARY/ABSTRACT Humans and numerous other species live in complex social environments, requiring many of our most important decisions to be made in the context of social interactions. All of our social relationships rely on our ability to make context-appropriate decisions, including significant ties with committed partners, family, and friends. The social decision-making (SDM) network hypothesis suggests that the expression of a given social behavior is reflected by the overall activity of a network of structures rather than activity of any single structure. Although the SDM network has been proposed on functional grounds, most of the supportive evidence is based on structural connectivity among loci and on examining the function of individual neurochemicals, brain areas, and neuronal mechanisms therein. We know surprisingly little about network function that regulates context-appropriate social behaviors. The socially monogamous prairie vole (Microtus ochrogaster) provides an opportunity to examine the neural mechanisms underlying social decisions which foster intimate relationships through the study of brain circuits regulating behavioral choices in interactions with current and potential partners. Our long-term goals are to dissect the neurocircuitry of social behavior (including the social behavior network and mesolimbic reward system), define normal and aberrant network activity during context-appropriate and context-inappropriate behaviors, respectively, and develop precise interventional tools that change circuit dynamics. Our theoretical neurocircuit of pair bond behaviors centers in five brain structures within the SDM network demonstrated to have functional specialization in regulating partner-directed affiliative behaviors, stranger-directed aggressive rejection, or both. Our specific aims will test the following hypotheses: (AIM 1) structural and functional connectivity between brain regions will vary depending on type of social stimuli and pair bond status; (AIM 2) Real-time recording in the SDM network will demonstrate that regional and interregional neural firing is distinct during (a) affiliative vs aggressive, (b) familiar vs unfamiliar, and (c) preferred vs non-preferred social interactions; and (AIM 3) altering neurochemical inputs into and activation of select projections out of a central hub will promote shifts in activity across the neural network and adjust what is considered context-appropriate behaviors. Upon conclusion, we will understand the role of regional and interregional activity within a network which governs behavioral choices that either enhance or marginalize intimate social ties. This contribution is significant as it will be the first study to utilize such time-sensitive measurements of neural activity within the SDM network in freely- moving voles and will service as a proof-of-concept for how this neural network guides decisions in other social scenarios which impact our most important social relationships. The proposed research is innovative as it employs simultaneous fast measurement and manipulation of neural activity of the SDM network to better address many aspects of network connectivity and integrates new technologies into in vole research, which may serve as a template for how these technologies can be adapted for other non-traditional animal models.

项目总结/摘要 人类和许多其他物种生活在复杂的社会环境中，需要我们许多最重要的 在社会互动的背景下做出的决定。我们所有的社会关系都依赖于我们的能力， 与环境相适应的决策，包括与忠诚的伴侣、家人和朋友的重要联系。社会 决策（SDM）网络假说认为，一个给定的社会行为的表达是反映 由一个网络结构的整体活动而不是任何单一结构的活动。虽然SDM 网络已经提出了功能的理由，大多数支持性证据是基于结构 基因座之间的连接和检查个别神经化学物质，脑区和神经元的功能， 其中的机制。令人惊讶的是，我们对网络功能知之甚少， 行为。社会一夫一妻制的草原田鼠（Microtus ochrogaster）提供了一个机会，研究 通过研究大脑，促进亲密关系的社会决策背后的神经机制 调节与当前和潜在伴侣互动中的行为选择的回路。我们的长期目标是 剖析社会行为的神经回路（包括社会行为网络和中脑边缘奖赏 系统），定义在上下文适当和上下文不适当期间正常和异常网络活动 行为，并开发精确的干预工具，改变电路动态。我们的理论 在SDM网络内的五个大脑结构中，成对键行为的神经回路中心被证明具有 在调节伙伴导向的亲和行为，陌生人导向的攻击行为， 拒绝，或两者。我们的具体目标将测试以下假设：（目的1）结构和功能 大脑区域之间的连接将根据社会刺激类型和配对状态而变化;（AIM 2） SDM网络中的实时记录将证明区域和区域间神经放电是不同的 在（a）亲和性与攻击性、（B）熟悉与不熟悉以及（c）偏好与非偏好的社交互动期间; 和（AIM 3）改变神经化学输入和激活选择投射出中央枢纽将 促进整个神经网络的活动变化，并调整被认为是上下文适当的行为。 在结束时，我们将了解区域和区域间活动在一个管理 这些行为选择要么增强要么边缘化亲密的社会关系。这一贡献意义重大，因为它将 成为第一个在SDM网络中自由使用这种时间敏感的神经活动测量的研究- 移动的田鼠，并将作为这个神经网络如何指导其他社会决策的概念验证。 影响我们最重要的社会关系的场景。这项研究是创新的，因为它 采用同时快速测量和操纵SDM网络的神经活动，以更好地 解决网络连接的许多方面，并将新技术集成到田鼠研究中， 作为这些技术如何适用于其他非传统动物模型的模板。