Training Program in Translational Brain Tumor Research

转化脑肿瘤研究培训计划

• 批准号: 8324744
• 负责人: Russell O. Pieper
• 金额: $ 23.8万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8324744
• 关键词: Brain Neoplasms; Research; Training Programs

DESCRIPTION (provided by applicant): The objective of this program is to provide postdoctoral training for individuals interested in pursuing careers in translational brain tumor research. Brain cancer remains among the most deadly of all malignancies, and despite the best efforts of neurosurgeons, neuro-oncologists, and laboratory-based scientists, the average survival of individuals with glioblastoma, the most malignant and common form of brain cancer, remains less than 15 months. Improvements in brain cancer therapy have come slowly, in part because of the relative dearth of individuals trained in a manner that allows them to communicate with both clinicians and lab-based investigators working in the field. This application is a new request for funding to support an existing program that focuses on developing translational brain tumor investigators of the future; individuals who can move seamlessly between clinical and laboratory worlds and in doing so can more effectively contribute to the development of new therapeutic interventions for brain tumors. This application requests support for 3 post-doctoral trainees per year, each of whom will be selected from PhD-level post-doctoral fellows attracted to the labs of the faculty, or from MD or MD/PhD trainees in the UCSF Neuro-Oncology Fellowship Program, or the UCSF Radiation Oncology Residency Program. The best qualified candidates then enter the training program, the core of which consists of the 20 research labs whose work has made the brain tumor community at UCSF one of the most productive and recognizable in the world. Over the course of the two years of support requested, the trainees work with the PIs of these labs to develop and complete meaningful and significant translational brain tumor research projects, and in the process become fluent in laboratory-based and clinical research techniques. At the same time trainees take part in a faculty-led didactic curriculum that is uniquely focused on issues of importance in brain tumors and which allow trainees to develop a common language with which to discuss and understand underlying brain tumor biology, diagnostic and therapeutic modalities, and unresolved problems in the field. Additional courses and training events that encourage effective speaking and writing are also included, and there is an extensive selection of existing courses to help tailor the educational experience of individual trainee's. Finally, evaluation and mentoring mechanisms are included to help ensure success in the program and in attaining future career goals. Although this is a new request for support, the Training Program in Translational Brain Tumor Research at UCSF has an extensive track record of attracting well-qualified individuals, and in successfully preparing investigators who have gone on to lead translational brain tumor research teams at UCSF, nationally, and internationally. The support requested will allow the brain tumor community at UCSF to expand efforts to train effective translational brain tumor investigators, and to ensure that such individuals will continue to be available to assume leadership roles in the fight against brain cancer. RELEVANCE: Adult brain cancer continues to be a significant challenge to clinicians. Although not among the most common organ-specific malignancies, there are over 20,000 cases diagnosed per year, and the mortality rate associated with brain tumors is among the highest of all cancers. Because the prognosis for individuals with the most common types of brain cancer remains poor, it is of critical Importance that new therapies be developed. This proposal requests funds to support a training program that takes promising young investigators and trains them to understand brain tumor biology and therapy as an integrated whole. Investigators trained in this stimulating and comprehensive manner will provide effective, competent leadership for future research efforts aimed at improved treatments and outcomes for brain tumor patients.

描述（由申请人提供）：该计划的目的是为有兴趣从事转化脑肿瘤研究的个人提供博士后培训。脑癌仍然是所有恶性肿瘤中最致命的一种，尽管神经外科医生、神经肿瘤学家和实验室科学家尽了最大努力，但胶质母细胞瘤（最恶性和最常见的脑癌形式）患者的平均生存期仍然不足 15 个月。脑癌治疗的改进进展缓慢，部分原因是相对缺乏接受过培训的人员，使他们能够与临床医生和在该领域工作的实验室研究人员进行沟通。该申请是一项新的资金请求，以支持现有的项目，该项目的重点是培养未来的转化脑肿瘤研究人员；能够在临床和实验室世界之间无缝移动的个人可以更有效地为脑肿瘤新治疗干预措施的开发做出贡献。 该申请要求每年支持 3 名博士后实习生，每名博士后实习生都将从吸引到该学院实验室的博士级博士后研究员中选拔，或者从 UCSF 神经肿瘤学奖学金计划或 UCSF 放射肿瘤学住院医师计划的 MD 或 MD/PhD 实习生中选拔。然后，最合格的候选人进入培训计划，该计划的核心由 20 个研究实验室组成，这些实验室的工作使加州大学旧金山分校的脑肿瘤社区成为世界上最富有成效和最受认可的社区之一。在两年的支持过程中，学员与这些实验室的 PI 合作，开发并完成有意义且重要的转化性脑肿瘤研究项目，并在此过程中熟练掌握基于实验室和临床的研究技术。同时，学员参加由教师主导的教学课程，该课程专门关注脑肿瘤的重要问题，使学员能够发展一种共同语言，用于讨论和理解潜在的脑肿瘤生物学、诊断和治疗方式以及该领域未解决的问题。还包括鼓励有效口语和写作的其他课程和培训活动，并且有大量现有课程可供选择，以帮助定制个别学员的教育体验。最后，还包括评估和指导机制，以帮助确保该计划取得成功并实现未来的职业目标。 尽管这是一项新的支持请求，但加州大学旧金山分校的转化脑肿瘤研究培训计划在吸引高素质人才方面有着广泛的记录，并成功地培养了研究人员，他们将在加州大学旧金山分校的国内和国际上领导转化脑肿瘤研究团队。所请求的支持将使加州大学旧金山分校的脑肿瘤界能够扩大培训有效的转化脑肿瘤研究人员的努力，并确保这些人将继续在抗击脑癌的斗争中发挥领导作用。 相关性：成人脑癌仍然是临床医生面临的重大挑战。虽然脑肿瘤不是最常见的器官特异性恶性肿瘤，但每年诊断出的病例超过 20,000 例，并且与脑肿瘤相关的死亡率是所有癌症中最高的。由于最常见类型脑癌患者的预后仍然较差，因此开发新疗法至关重要。该提案要求资金支持一项培训计划，该计划吸引有前途的年轻研究人员并培训他们了解脑肿瘤生物学和治疗作为一个整体。以这种刺激和全面的方式接受培训的研究人员将为未来旨在改善脑肿瘤患者治疗和结果的研究工作提供有效、称职的领导。