胰腺癌中的 UAB / UMN SPORE-猫眼课题宝

胰腺癌中的 UAB / UMN SPORE

批准号：

8277122

负责人：

DONALD J. BUCHSBAUM

金额：

$230.0万

依托单位：

UNIVERSITY OF ALABAMA AT BIRMINGHAM

依托单位国家：

美国

项目类别：

财政年份：

2003

资助国家：

美国

项目状态：

已结题

起止时间：

2003-09-16 至 2015-06-30

来源：

https://reporter.nih.gov/project-details/8277122

关键词：

Adenovirus Vector Advisory Committees Advocacy Advocate Agreement Animal Model Bioinformatics Biological Markers Biology Biometry Biopsy Biostatistics Core Brain Breast Cancer Biology Cancer Patient Cancer cell line Cantor Cell Line Cell physiology Cellular biology Chairperson Cities Clinic Clinical Clinical Data Clinical Investigator Clinical Management Clinical Research Clinical Services Clinical Trials Collaborations Collection Communication Comprehensive Cancer Center Critiques Data Data Analyses Data Collection Development Diagnosis Disease Doctor of Medicine Doctor of Philosophy Ductal Epithelial Cell Engineering Enrollment Ensure Erbitux Evaluation Event External Beam Radiation Therapy Faculty Fine needle aspiration biopsy Funding Future Gene Expression Profiling Genes Genetic Genomics Grant Group Meetings Guidelines Head Heat shock proteins Hematology Hospitals Human Human Genetics Image Immunology Institution Interdisciplinary Study Interview Joints Laboratories Lead Leadership Magnetic Resonance Imaging Malignant Neoplasms Malignant neoplasm of pancreas Medical center Medicine Methodology Methods Minnesota Modeling Molecular Molecular Medicine Monoclonal Antibodies Morehouse School of Medicine Mus Mutation Neoplasm Metastasis Newly Diagnosed Operative Surgical Procedures Pancreas Paraffin Embedding Participant Pathology Pathway interactions Patient advocacy Patients Pattern Personal Behavior Persons Phase I Clinical Trials Phase II Clinical Trials Phenotype Pilot Projects Policies Population Preparation Preventive Medicine Principal Investigator Problem Solving Procedures Process Productivity Proteomics Protocols documentation Public Health Schools Publications Quality Control Radiation Oncology Recommendation Reporting Research Research Activity Research Personnel Research Project Grants Research Support Research Training Resistance Resource Allocation Reverse Transcriptase Polymerase Chain Reaction Role Sampling Schools Science Scientific Evaluation Scientist Serum Site Staging Study Section Surgeon Surgical Oncology TNFRSF10B gene Techniques Technology Teleconferences Therapeutic Therapeutic Studies Time Tissue Banks Tissues Transgenic Animals Transgenic Mice Transgenic Organisms Translational Research Translations Transplantation Treatment Efficacy Twin Multiple Birth United States National Institutes of Health Universities University of Minnesota Cancer Center University of Texas M D Anderson Cancer Center Urine Videoconferences Videoconferencing Virginia Visit Walkers Wood material Work base bench to bedside cancer education cancer research center director cancer stem cell career development cellular pathology data management density design experience gemcitabine immunopathology informatics shared resource malignant breast neoplasm medical schools meetings member molecular pathology mouse model neoplastic cell novel oncology pancreatic cancer cells professor prognostic indicator programs research and development response sample collection standard of care statistical service tissue resource tumor progression

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英文摘要

Six years ago, our UAB SPORE in Pancreatic Cancer application was partially funded via a P-20 grant. With limited funding; our mini-SPORE was composed of 2 major projects, 3 Cores and a Developmental Research Program. During this initial funding period, translation of SPORE science resulted in two phase I trials, one Phase II trial and a novel MRI imaging trial. The investigators of the SPORE have 88 publications relating to SPORE projects or pancreatic cancer. The Developmental Research funding resulted in two major projects, Projects 1, & 4 in this renewal application and 2 awardees becoming Project co-leaders. Three years ago, Dr. Vickers (SPORE PI) became Chairman of Surgery at the University of Minnesota (UMN) and we restructured into a joint UAB/UMN SPORE in Pancreatic Cancer. The joint SPORE has functioned well and this proposal is our amended competitive renewal for full SPORE funding (PSO application). This proposal has 4 major projects: Project 1 is utilizing proteomic techniques in transgenic animal models to identify biomarkers that are predictive of early stage pancreatic cancer; Project 2 is a continuation project which is examining multiple methods to enhance the therapeutic efficacy of anti-DR5 monoclonal antibodies in pancreatic cancer animal models and patients; Project 3 is utilizing genomic and genetic data obtained from human pancreatic cancer (PCa) samples and observations from mouse models of PCa to understand the genetic events that drive metastasis and treatment resistance in this disease. These studies will lead to a phase I clinical trial; Project 4 is engineering novel conditionally replicative adenoviral vectors that target pancreatic cancer stem cell-like tumor cells for the treatment of metastatic pancreatic cancer. The four important and effective Cores are: 1) Administration; 2) Tissue Resource and Molecular Pathology; 3) Biostatistics; and 4) Clinical Management and Trials (Advocacy Sub-Core). We also request support for continuation of our Developmental Research and Career Development Programs which includes Morehouse School of Medicine and Tuskegee University. The application has strong institutional support from UAB and UMN, excellent pancreatic cancer populations and concurrence with federal guidelines.

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