Career Development Program

胰腺癌孢子职业发展计划(CDP)的目标是招募和培训胰腺癌转化性研究的基础和临床研究人员。我们主要关注年轻的研究人员，他们拥有UMN、UAB、莫尔豪斯医学院(MSM)或塔斯基吉大学(TU)适当的基础科学或临床系的讲师、助理教授或副教授的教职。我们建议在经验丰富的导师团队的监督下，将它们纳入正在进行的孢子研究中。获奖者将接触和参与孢子的跨学科和翻译研究重点，并与来自所有四个机构的孢子研究人员互动。不太常见的是，接受者可能是具有成功研究记录的较高级别的个人，他/她希望改变自己的职业道路，从事胰腺癌转化性研究。 我们期望获奖者确定、开发和完成适当的研究项目，并寻求其他职业发展奖励和资助，作为启动成功的独立研究事业过程的一部分，并通过这样做进一步扩大孢子翻译研究工作。 我们的总体战略是确定优秀的候选人，指派一名导师帮助制定一份供CDP小组委员会审查的预提案，然后指派导师团队的其余成员，包括一名统计学家，帮助制定完整的提案。CDP小组委员会将审查全部提案，以选出最终获奖者。在获奖期间，导师团队将继续与获奖者合作。 我们建议每年颁发2个职业发展奖，每个奖项的资金为50,000美元。每年100,000美元的年度预算来自UAB孢子预算(50,000美元)以及UMN机构基金 每年50,000美元。机构职业发展基金分别与每个机构的联邦CDP基金(UAB池和UMN池)汇集在一起。我们从每个机构的个人资金池中为每个机构的项目提供资金，但科学审查和资金决定是由一个联合孢子委员会CDP小组委员会做出的。为Tuskegee和Morehouse提供资金的项目有分包合同，所有合同都不允许间接成本。此外，UAB机构基金750,000美元将为UAB在胰腺癌生物学或免疫学领域招募一名新的胰腺癌孢子提供部分支持。 鉴于维克斯博士和山本博士离开UMN，后一次招聘是为了加强UAB的胰腺癌研究人员。同样，UMN已承诺提供100万美元，用于招聘两名实体肿瘤生物学家，这可能会进一步加强他们对胰腺癌的研究。 总体而言，我们用一种新的方法大大加强了CDP提案，并有力地解决了每一个已确定的弱点。新方法侧重于UMN、UAB、MSM和TU，由UMN和UAB孢子调查员联合开发，具体包括生物统计核心及其协调委员会，该委员会由UMN和UAB的教职统计学家组成。统计学家 具体包括O.Dale Williams博士、Alan Cantor博士、Chap Le博士、Sreeltha Meleth博士和Sharina Person博士。 其中，威廉姆斯博士和Person博士在预防医学部的MSM和TU的类似活动中有相当的经验，UAB综合癌症中心(CCC)也有持续的职业生涯 与这两个机构共同开展发展活动，并定期与这两个机构举行视频会议。 实施这一新计划的总体战略在正文中的图1中突出显示。其实质是，申请者将被征集并分配一名主要导师，该导师将指导预先提案的制定；预先提案将被审查，以选择完整的提案。一个三人导师小组，包括一名统计学家，将被指派帮助指导申请者制定一份完整的提案。导师团队将与被选中的申请者一起获得资助，并在整个奖项有效期内提供帮助。 我们有完整的导师，包括这一过程所需的教职员工统计学家。

The goal of the Career Development Program (CDP) of the Pancreatic Cancer SPORE is to recruit and train basic and clinical investigators for translational pancreatic cancer research. We focus primarily on young investigators with a faculty appointment at the rank of Instructor, Assistant Professor, or Associate Professor in an appropriate basic science or clinical department at UMN, UAB, Morehouse School of Medicine (MSM) or Tuskegee University (TU). We propose to incorporate them into the ongoing SPORE research under the supervision of an experienced mentor team. Awardees will be exposed to and participate in the interdisciplinary and translational research emphasis of the SPORE and interact with SPORE investigators from all four institutions. Less commonly, the recipient may be an individual at a more senior level with a successful research record, who wishes to alter his/her career path to pancreatic cancer translational research. We expect the awardees to identify, develop and complete an appropriate research project and also to seek other career development awards and grant support as a part of the process of initiating a successful Independent research career and by so doing to further expand the SPORE translational research effort. Our overall strategy is to identify outstanding candidates, assign a mentor to assist with developing a preproposal for review by the CDP Subcommittee, and then assign the remainder of the mentor team, to include a statistician, to help with developing the full proposal. The full proposals will be reviewed by the CDP Subcommittee for selection of the final awardees. The mentor team would continue to work with the awardee for the duration ofthe award. We propose to award 2 Career Development awards/year with funding at $50,000/award. The annual budget of $100,000 per year is derived from the SPORE budget of UAB ($50,000) as well as UMN institutional funds of $50,000/year. The institutional career development funds are pooled with the individual federal CDP funds at each institution separately (UAB pool and UMN pool). We fund projects at each institution out of their individual pools, but scientific review and funding decisions are made by a single joint SPORE committee, the CDP Subcommittee. Projects funded for Tuskegee and Morehouse have subcontracts, and all awards do not allow indirect costs. In addition, UAB institutional funds of $750,000 will provide partial support for recruitment of a new Pancreatic Cancer SPORE recruit at UAB in the field of pancreatic cancer biology or immunology. This latter recruitment is to enhance the pancreatic cancer research faculty at UAB given the departure of Drs. Vickers and Yamamoto to UMN. Similarly, UMN has committed $1 million for the recruitment of two solid tumor biologists which may further strengthen their research in pancreatic cancer. Overall, we have strengthened the CDP proposal considerably with a new approach and have addressed strongly each ofthe identified weaknesses. The new approach focuses on UMN, UAB, MSM, and TU and was developed jointly by the UMN and UAB SPORE investigators and specifically included the Biostatistics Core and its Coordinating Committee containing faculty statisticians from both UMN and UAB. Statisticians specifically included were Drs. O. Dale Williams, Alan Cantor, Chap Le, Sreeletha Meleth and Sharina Person. Of these, Drs. Williams and Person have considerable experience with similar activities with MSM and TU in the Division of Preventive Medicine and the UAB Comprehensive Cancer Center (CCC) have ongoing career development activities with both institutions and participate in regular videoconferences with both. The overall strategy for implementing this new program is highlighted in Figure 1 in the text. The essence is that applicants will be solicited and assigned a primary mentor who will guide the development of a preproposal; pre-proposals will be reviewed for selection for a full proposal. A three member mentor team, to include a statistician, will be assigned to help guide the applicant in the development of a full proposal. The mentor team will remain with the applicants selected for funding and assist throughout the life of the award. We have a full complement of mentors, including faculty statisticians that will be needed for this process.