Career Development Program

胰腺癌 SPORE 职业发展计划 (CDP) 的目标是招募和培训转化胰腺癌研究的基础和临床研究人员。我们主要关注在 UMN、UAB、莫尔豪斯医学院 (MSM) 或塔斯基吉大学 (TU) 相应基础科学或临床部门担任讲师、助理教授或副教授级别的年轻研究人员。我们建议在经验丰富的导师团队的监督下将它们纳入正在进行的 SPORE 研究中。获奖者将接触并参与 SPORE 的跨学科和转化研究重点，并与来自所有四个机构的 SPORE 研究人员互动。不太常见的是，接受者可能是具有成功研究记录的更高级别的个人，他们希望改变他/她的职业道路以从事胰腺癌转化研究。 我们希望获奖者能够确定、开发和完成适当的研究项目，并寻求其他职业发展奖项和资助，作为启动成功的独立研究生涯过程的一部分，并通过这样做进一步扩大 SPORE 转化研究工作。 我们的总体策略是确定优秀候选人，指派一名导师协助制定预提案供 CDP 小组委员会审查，然后指派导师团队的其余成员（包括一名统计学家）帮助制定完整的提案。 CDP 小组委员会将审查完整的提案，以选出最终获奖者。导师团队将在获奖期间继续与获奖者合作。 我们建议每年颁发 2 个职业发展奖，资助金额为每个奖项 50,000 美元。每年 100,000 美元的年度预算来自 UAB 的 SPORE 预算（50,000 美元）以及 UMN 机构资金 50,000 美元/年。机构职业发展基金分别与每个机构的联邦 CDP 基金（UAB 资金池和 UMN 资金池）合并。我们从每个机构各自的资金池中资助项目，但科学审查和资助决定由单个 SPORE 联合委员会（CDP 小组委员会）做出。塔斯基吉和莫尔豪斯资助的项目都有分包合同，所有资助都不允许产生间接成本。此外，UAB 750,000 美元的机构资金将为 UAB 胰腺癌生物学或免疫学领域新招募的胰腺癌 SPORE 人员提供部分支持。 鉴于 Dr. 的离开，后者的招聘是为了增强 UAB 的胰腺癌研究人员队伍。维克斯和山本前往UMN。同样，UMN 已投入 100 万美元用于招募两名实体瘤生物学家，这可能会进一步加强他们在胰腺癌方面的研究。 总体而言，我们通过新方法大大加强了 CDP 提案，并有力地解决了每个已发现的弱点。新方法侧重于 UMN、UAB、MSM 和 TU，由 UMN 和 UAB SPORE 研究人员联合开发，特别包括生物统计学核心及其由 UMN 和 UAB 的教员统计学家组成的协调委员会。统计学家 特别包括的是博士。 O. Dale Williams、Alan Cantor、Chap Le、Sreeletha Meleth 和 Sharina Person。 其中，博士。 Williams 和 Person 在预防医学部门与 MSM 和 TU 开展类似活动方面拥有丰富的经验，并且 UAB 综合癌症中心 (CCC) 正在开展职业生涯 与两个机构一起开展开发活动，并参加与两个机构的定期视频会议。 文中图 1 突出显示了实施这一新计划的总体策略。本质上是，申请人将被征求并指派一位主要导师来指导预提案的制定；将审查预提案以选择完整提案。将指派一个由三人组成的导师团队（其中包括一名统计学家）来帮助指导申请人制定完整的提案。导师团队将留在被选中获得资助的申请人身边，并在整个奖项期间提供协助。 我们拥有完整的导师，包括这一过程所需的教员统计学家。

The goal of the Career Development Program (CDP) of the Pancreatic Cancer SPORE is to recruit and train basic and clinical investigators for translational pancreatic cancer research. We focus primarily on young investigators with a faculty appointment at the rank of Instructor, Assistant Professor, or Associate Professor in an appropriate basic science or clinical department at UMN, UAB, Morehouse School of Medicine (MSM) or Tuskegee University (TU). We propose to incorporate them into the ongoing SPORE research under the supervision of an experienced mentor team. Awardees will be exposed to and participate in the interdisciplinary and translational research emphasis of the SPORE and interact with SPORE investigators from all four institutions. Less commonly, the recipient may be an individual at a more senior level with a successful research record, who wishes to alter his/her career path to pancreatic cancer translational research. We expect the awardees to identify, develop and complete an appropriate research project and also to seek other career development awards and grant support as a part of the process of initiating a successful Independent research career and by so doing to further expand the SPORE translational research effort. Our overall strategy is to identify outstanding candidates, assign a mentor to assist with developing a preproposal for review by the CDP Subcommittee, and then assign the remainder of the mentor team, to include a statistician, to help with developing the full proposal. The full proposals will be reviewed by the CDP Subcommittee for selection of the final awardees. The mentor team would continue to work with the awardee for the duration ofthe award. We propose to award 2 Career Development awards/year with funding at $50,000/award. The annual budget of $100,000 per year is derived from the SPORE budget of UAB ($50,000) as well as UMN institutional funds of $50,000/year. The institutional career development funds are pooled with the individual federal CDP funds at each institution separately (UAB pool and UMN pool). We fund projects at each institution out of their individual pools, but scientific review and funding decisions are made by a single joint SPORE committee, the CDP Subcommittee. Projects funded for Tuskegee and Morehouse have subcontracts, and all awards do not allow indirect costs. In addition, UAB institutional funds of $750,000 will provide partial support for recruitment of a new Pancreatic Cancer SPORE recruit at UAB in the field of pancreatic cancer biology or immunology. This latter recruitment is to enhance the pancreatic cancer research faculty at UAB given the departure of Drs. Vickers and Yamamoto to UMN. Similarly, UMN has committed $1 million for the recruitment of two solid tumor biologists which may further strengthen their research in pancreatic cancer. Overall, we have strengthened the CDP proposal considerably with a new approach and have addressed strongly each ofthe identified weaknesses. The new approach focuses on UMN, UAB, MSM, and TU and was developed jointly by the UMN and UAB SPORE investigators and specifically included the Biostatistics Core and its Coordinating Committee containing faculty statisticians from both UMN and UAB. Statisticians specifically included were Drs. O. Dale Williams, Alan Cantor, Chap Le, Sreeletha Meleth and Sharina Person. Of these, Drs. Williams and Person have considerable experience with similar activities with MSM and TU in the Division of Preventive Medicine and the UAB Comprehensive Cancer Center (CCC) have ongoing career development activities with both institutions and participate in regular videoconferences with both. The overall strategy for implementing this new program is highlighted in Figure 1 in the text. The essence is that applicants will be solicited and assigned a primary mentor who will guide the development of a preproposal; pre-proposals will be reviewed for selection for a full proposal. A three member mentor team, to include a statistician, will be assigned to help guide the applicant in the development of a full proposal. The mentor team will remain with the applicants selected for funding and assist throughout the life of the award. We have a full complement of mentors, including faculty statisticians that will be needed for this process.