Analyzing National Complex Sample Surveys for Epidemiologic Studies of Cancer

分析癌症流行病学研究的全国复杂抽样调查

• 批准号: 8297686
• 负责人: Stuart R. Lipsitz
• 金额: $ 36.81万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8297686
• 关键词: Behavior; Behavioral Risk Factor Surveillance System; Boxing; Cancer Patient; Cancer Survivor; Caring; Complex; Computer software; Confidence Intervals; Data; Databases; Diet; Disease; Documentation; Epidemiologic Studies; Epidemiologist; Epidemiology; Equation; Expenditure; Frequencies; Future; Goals; Health Information National Trends Survey; Hospice Care; Incidence; Inequality; Inpatients; Intake; Internet; Lead; Length of Stay; Linear Models; Logistic Regressions; Malignant Neoplasms; Medical; Methodology; Methods; Modeling; National Health Interview Survey; National Health and Nutrition Examination Survey; Nutrient; Population; Prevalence; Probability; Procedures; Publications; Rank-Sum Tests; Research Personnel; Risk; Risk Factors; Sampling; Sampling Biases; Screening for cancer; Screening procedure; Smoking; Statistical Methods; Stratification; Subgroup; Survey Methodology; Surveys; Testing; Treatment Cost; United States; base; cancer epidemiology; cost; design; diet and cancer; end of life; follow-up; interest; novel; novel strategies; patient home care; population based; statistics

DESCRIPTION (provided by applicant): The ready availability of public-use data from large National population-based complex surveys have immense potential to lead to the assessment of (1) population frequency of cancer (incidence and prevalence); (2) hospital length of stay and related costs for treatment; (3) cancer screening rates; (4) newly discovered associations between risk factors (e.g. screening rates, diet) and different cancers. The goal of this project i to demonstrate this potential using novel statistical methods applied to at least seven United States complex surveys. Specifically, we will use the Behavioral Risk Factor Surveillance System and the Health Information National Trends Survey to describe screening rates; the National Health and Nutrition Examination Survey to explore behaviors (diet, smoking, etc.) in current and future cancer patients; the Nationwide Inpatient Sample and the Medical Expenditure Panel Survey to describe hospital length of stay and related costs for treating cancer; the National Home and Hospice Care Survey to explore end-of-life care for cancer patients; and the National Health Interview Survey to examine follow-up of cancer survivors. Complex sample surveys present some quite unique problems, and we will develop appropriate models and methods complex surveys. Our proposal has three broad aims of significance to medical researchers. (1) New statistical approaches for small subgroup analyses in which the standard large sample complex survey methods can be inappropriate; 2) New statistical procedures for databases that are too large for the usual complex survey approaches to be feasible; and 3) Complex survey methods for skewed data. An additional goal is to make the newly developed statistical/epidemiological methodology widely accessible to non-statisticians. For the methods described in each aim, we plan to create macros and procedures which can be used with existing, widely-used statistical packages (e.g., SAS). Statistical macros and procedures will be documented and made available on the Internet, together with documentation on how to apply these macros to the examples analyzed in the resulting publications. PUBLIC HEALTH RELEVANCE: National complex survey data are used often in cancer epidemiology. We propose new approaches for analyzing such data that are theoretically valid, technically simple and can be implemented within most standard sample survey packages.

描述（由申请人提供）：来自大型国家人口综合调查的公共使用数据的现成可用性具有巨大的潜力，可用于评估（1）癌症的人口频率（发病率和患病率）;（2）住院时间和相关治疗费用;（3）癌症筛查率;（4）新发现的风险因素（如筛查率、饮食）与不同癌症之间的关联。本项目的目标是使用至少适用于七个美国复杂调查的新统计方法来证明这种潜力。具体来说，我们将使用行为风险因素监测系统和健康信息全国趋势调查来描述筛查率;全国健康和营养检查调查来探索行为（饮食，吸烟等）。在当前和未来的癌症患者;全国住院病人样本和医疗支出小组调查，以描述住院时间和治疗癌症的相关费用;国家家庭和临终关怀调查，以探索癌症患者的临终关怀;和国家健康访谈调查，以检查癌症幸存者的后续行动。复杂的抽样调查提出了一些相当独特的问题，我们将开发适当的模型和方法复杂的调查。我们的提案有三个对医学研究人员具有重要意义的广泛目标。(1)用于小型亚组分析的新统计方法，其中标准的大样本复杂调查方法可能不合适; 2）用于数据库的新统计程序，对于通常的复杂调查方法来说太大而不可行;以及3）用于偏斜数据的复杂调查方法。另一个目标是使新制定的统计/流行病学方法广泛为非统计人员所用。对于每个目标中描述的方法，我们计划创建可以与现有的广泛使用的统计软件包（例如，SAS）。将记录统计宏指令和程序，并在因特网上提供，同时提供关于如何将这些宏指令应用于所产生的出版物中分析的实例的文件。 公共卫生相关性：国家复杂的调查数据经常用于癌症流行病学。我们提出了新的方法来分析这些数据，理论上是有效的，技术上简单，可以在大多数标准的抽样调查包。