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Mechanisms of Social Isolation and Environmental Enrichment in an Animal Model

动物模型中的社会孤立和环境丰富机制

基本信息

批准号：
8365308
负责人：
ANGELA J GRIPPO
金额：
$ 35.44万
依托单位：
NORTHERN ILLINOIS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-05 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8365308
关键词：
Abbreviations Academic Research Enhancement Awards Affective Symptoms Aging American Analysis of Variance Anhedonia Animal Model Animals Anxiety Applications Grants Autonomic Dysfunction Behavior Behavioral Biological Assay Biological Models Blood Pressure Brain Brain Stem Brain region CRH gene Cardiovascular Diseases Cardiovascular Physiology Cardiovascular system Caring Cognition Communication Corticotropin-Releasing Hormone Data Development Emotional Emotions Ensure Environment Equilibrium Exhibits Exposure to Extended Family Family Female Functional disorder Future Genes Grant Heart Heart Diseases Heart Rate Housing Human Individual International Investigation Laboratories Lead Learned Helplessness Life Link Manuscripts Measures Mediating Mental Depression Methodology Modeling Molecular Mood Disorders Moods Nervous System Physiology Neural Pathways Neuraxis Neurobiology Patients Peripheral Physical activity Physiological Physiology Play Population Process Publishing Regulation Reliance Research Research Project Grants Research Proposals Risk Rodent Rodent Model Role Science Social Behavior Social Environment Social isolation Stress Stress and Coping Swimming Tail Suspension Testing United States behavior test biological adaptation to stress depressive symptoms design effective therapy environmental enrichment for laboratory animals experience graduate student heart rate variability immunoreactivity improved innovation neurobiological mechanism novel outreach paraventricular nucleus prairie vole prevent protective effect psychologic relating to nervous system research study response social social attachment stressor success undergraduate student

项目摘要

DESCRIPTION (provided by applicant): This research will investigate the effects of an environmental treatment (environmental enrichment), for preventing the negative emotional and cardiovascular consequences of social isolation in the context of depression and heart disease. There is a bidirectional association between depression and heart disease, and this relationship is especially important for people with specific vulnerabilities such as aging populations or individuals who lack beneficial social experiences. Psychological and physiological responses to social stressors and isolation play an important role in the development of affective symptoms and cardiovascular dysfunction. However, current treatments for individuals with depression and heart disease are significantly limited. The present project will use a rodent model, the socially monogamous prairie vole, to study behavioral, autonomic responses to a social stressor (social isolation), and potential molecular mechanisms that underlie environmental enrichment as a treatment for these negative consequences. Preliminary findings, from our laboratory and others, indicate that environmental enrichment - involving increased stimulation from the environment in the form of inanimate objects and physical activity - has beneficial effects on several central nervous system functions, and can improve emotional reactivity and behaviors associated with depression. The prairie vole is a valuable model system for studying responsiveness to social experiences and neurobiological mechanisms related to mood and cardiovascular function. This species displays several unique social behaviors that mimic those of humans, including living in extended families and forming enduring social bonds; and also exhibits autonomic regulation of the heart similar to humans. Using the prairie vole model, Specific Aim 1 will employ behavioral tests of depression and continuous recording of cardiovascular variables including blood pressure, heart rate, heart rate variability, and autonomic balance, to test the hypothesis that environmental enrichment is an effective treatment for behavioral and cardiovascular consequences of social isolation. Specific Aim 2 will employ measures of central nervous system genes including delta-FosB immunoreactivity, to investigate the hypothesis that long-term alterations in cortical, limbic, and autonomic brain regions underlie the positive effects of environmental enrichment in animals that are socially isolated. This research proposes a novel mechanism by which the social environment impacts behavior, physiology, and brain function, and will promote the development of more comprehensive treatments for patients with depression and cardiovascular disease. PUBLIC HEALTH RELEVANCE: The association between depression and heart disease is bidirectional, and is significantly influenced by the social environment. The current research project will investigate, in an animal model, the ability of an environmental treatment to protect against negative behavioral, cardiovascular, and brain processes associated with mood and cardiovascular dysfunction. This research will lead to the development of more effective treatments for patients with depression and heart disease.

描述（由申请人提供）：本研究将调查环境治疗（环境富集）对预防抑郁和心脏病背景下社会孤立的负面情绪和心血管后果的影响。抑郁症和心脏病之间存在双向关联，这种关系对具有特定脆弱性的人尤其重要，比如人口老龄化或缺乏有益社会经验的人。对社会压力源和孤立的心理和生理反应在情感性症状和心血管功能障碍的发展中起重要作用。然而，目前对抑郁症和心脏病患者的治疗非常有限。本项目将使用啮齿动物模型，社会一夫一妻制草原田鼠，来研究对社会压力源（社会孤立）的行为自主反应，以及潜在的分子机制，这些机制是环境富集作为这些负面后果治疗的基础。我们的实验室和其他人的初步研究结果表明，环境丰富——包括以无生命物体和身体活动的形式增加来自环境的刺激——对几种中枢神经系统功能有有益的影响，并能改善与抑郁相关的情绪反应和行为。草原田鼠是研究对社会经验的反应和与情绪和心血管功能相关的神经生物学机制的一个有价值的模型系统。这个物种表现出几种独特的模仿人类的社会行为，包括生活在大家庭中，形成持久的社会关系；也表现出与人类相似的心脏自主调节。利用草原田鼠模型，Specific Aim 1将采用抑郁症的行为测试和心血管变量（包括血压、心率、心率变异性和自主平衡）的连续记录，来检验环境丰富是社会孤立行为和心血管后果的有效治疗这一假设。特异性目标2将采用中枢神经系统基因的测量方法，包括delta-FosB免疫反应性，来研究在社会隔离的动物中，皮质、边缘和自主脑区域的长期改变是环境富集的积极作用的基础。本研究提出了社会环境影响行为、生理和脑功能的新机制，将促进抑郁症和心血管疾病患者更综合治疗的发展。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Voluntary physical exercise protects against behavioral and endocrine reactivity to social and environmental stressors in the prairie vole.

DOI：
10.1080/17470919.2017.1365761
发表时间：
2018-10
期刊：
Social neuroscience
影响因子：
2
作者：
Watanasriyakul WT;Wardwell J;McNeal N;Schultz R;Woodbury M;Dagner A;Cox M;Grippo AJ
通讯作者：
Grippo AJ

Protective neuroendocrine effects of environmental enrichment and voluntary exercise against social isolation: evidence for mediation by limbic structures.

环境丰富和自愿锻炼对社会孤立的保护性神经内分泌作用：边缘结构调节的证据。

DOI：
10.1080/10253890.2019.1617691
发表时间：
2019
期刊：
Stress (Amsterdam, Netherlands)
影响因子：
0
作者：
Watanasriyakul,WTang;Normann,MarignyC;Akinbo,OreoluwaI;Colburn,William;Dagner,Ashley;Grippo,AngelaJ
通讯作者：
Grippo,AngelaJ

Social isolation and oxytocin antagonism increase emotion-related behaviors and heart rate in female prairie voles.

DOI：
10.1016/j.autneu.2022.102967
发表时间：
2022-05
期刊：
Autonomic neuroscience : basic & clinical
影响因子：
0
作者：
Watanasriyakul WT;Scotti ML;Carter CS;McNeal N;Colburn W;Wardwell J;Grippo AJ
通讯作者：
Grippo AJ

Behavioral and neuroendocrine consequences of disrupting a long-term monogamous social bond in aging prairie voles.