Social Isolation, Behavior, and Autonomic Function

社会孤立、行为和自主功能

• 批准号: 7123386
• 负责人: ANGELA J GRIPPO
• 金额: $ 5.04万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2007-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7123386
• 关键词: anxiety; brain metabolism; cardiovascular disorder; cardiovascular function; corticosterone; depression; exploratory behavior; heart rate; hormone metabolism; hormone regulation /control mechanism; immunocytochemistry; isolation /deprivation; mood disorders; neurohormones; neuropsychology; oxytocin; paraventricular nucleus; postdoctoral investigator; psychological reinforcement; psychological stressor; psychomotor function; radioimmunoassay; suprachiasmatic nucleus; telemetry; vole

DESCRIPTION (provided by applicant): This proposal addresses central oxytocinergic mechanisms underlying the interactions of affective behaviors, neuroendocrine function, and autonomic activity by investigating the effects of social isolation in female prairie voles. This research is directly relevant to health issues such as social behavior, depression, anxiety, and heart disease. Study 1 employs radioimmunoassay, enzyme immunoassay, and immunocytochemistry to investigate the time course of hormone changes in plasma and hypothalamic brain tissue following social isolation in voles (Aim 1). Study 2 examines depression- and anxiety-like behaviors and endocrine function, and uses radiotelemetry to measure autonomic parameters, in response to social isolation (Aim 2). Study 3 investigates specific oxytocinergic mechanisms that might underlie stressor-induced changes by examining central (intracerebroventricular) administration of oxytocin and/or an oxytocin antagonist to alter the behavioral, neuroendocrine, and autonomic responses to social isolation (Aim 3). The present research will enhance our understanding of how the social environment impacts behavior, physiology, and brain function, and can aid in developing new treatments for patients with affective disorders and cardiovascular disease.

描述（由申请人提供）：该提案通过研究雌性草原田鼠的社会隔离的影响，解决了情感行为、神经内分泌功能和自主活动相互作用背后的中枢催产素机制。这项研究与社会行为、抑郁、焦虑和心脏病等健康问题直接相关。研究 1 采用放射免疫测定、酶免疫测定和免疫细胞化学来研究田鼠社会隔离后血浆和下丘脑脑组织中激素变化的时间过程（目标 1）。研究 2 检查抑郁和焦虑样行为以及内分泌功能，并使用无线电遥测技术测量自主神经参数，以应对社会隔离（目标 2）。研究 3 通过检查催产素和/或催产素拮抗剂的中枢（脑室内）给药来改变对社会隔离的行为、神经内分泌和自主反应，研究可能是应激源引起的变化的特定催产素机制（目标 3）。目前的研究将增强我们对社会环境如何影响行为、生理和大脑功能的理解，并有助于为情感障碍和心血管疾病患者开发新的治疗方法。

项目成果

The integration of depressive behaviors and cardiac dysfunction during an operational measure of depression: investigating the role of negative social experiences in an animal model.

• DOI: 10.1097/psy.0b013e31825ca8e5
• 发表时间: 2012-07
• 期刊: Psychosomatic medicine
• 影响因子: 3.3
• 作者: Grippo AJ;Moffitt JA;Sgoifo A;Jepson AJ;Bates SL;Chandler DL;McNeal N;Preihs K
• 通讯作者: Preihs K