The Influence of Diet and Lifestyle on Patients with Advanced Colorectal Cancer

饮食和生活方式对晚期结直肠癌患者的影响

• 批准号: 8264385
• 负责人: JEFFREY A MEYERHARDT
• 金额: $ 62.48万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8264385
• 关键词: Address; Area; Aspirin; Blood specimen; Body mass index; C-Peptide; Cancer Biology; Cancer Patient; Cancer and Leukemia Group B; Cardiovascular system; Cetuximab; Characteristics; Colon Carcinoma; Colorectal Cancer; Combination Drug Therapy; Comorbidity; Data; Databases; Development; Diagnosis; Diet; Dietary Intervention; Disease; Epidemiology; Epidermal Growth Factor Receptor; Future; Glycemic Index; Health Personnel; Human; Insulin; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Integration Host Factors; Knowledge; Lead; Leptin; Life; Life Style; Malignant Neoplasms; Molecular; Mutate; NIH Program Announcements; National Cancer Institute; Neoplasm Metastasis; Newly Diagnosed; Non-Steroidal Anti-Inflammatory Agents; Obesity; Outcome; Paraffin Embedding; Pathway interactions; Patients; Pattern; Performance Status; Pharmaceutical Preparations; Physical activity; Plasma; Proteins; Proto-Oncogene Proteins c-akt; Recommendation; Research; Residual state; Risk; Specimen; Staging; Time; Toxic effect; Vitamin D; Vitamin D3 Receptor; abstracting; adiponectin; angiogenesis; bevacizumab; celecoxib; chemotherapy; cohort; cyclooxygenase 2; density; disease characteristic; energy balance; experience; follow-up; improved; indexing; lifestyle factors; lifestyle intervention; metastatic colorectal; mortality; outcome forecast; overexpression; pre-clinical; prevent; prospective; randomized trial; response; tumor; tumor growth; tumor progression

Project Summary/Abstract Epidemiologic and scientific research indicates that diet and other lifestyle factors have a significant influence on the risk of developing colorectal cancer. Emerging data suggest some of these factors impact on the outcomes of patients with early stage colon cancer. However, there are no data on the influence of diet, lifestyle and other host factors on the outcomes of patients with more advanced colorectal cancer. At the time of initial diagnosis, 20% of colorectal cancer patients have evidence of metastases and another 15- 20% will recur with metastatic disease within a few years of initial diagnosis. In the past 10 years, there have been substantial improvements in chemotherapy options for these patients, with median survival exceeding 2 years and increasing number of patients living 4 or more years. Patients often seek to understand what, if any, diet and lifestyle will improve their outcomes, both survival and tolerability of therapy. Moreover, how diet and lifestyle influence prognosis may depend, in part, on molecular characteristics of the tumor. In response to a NIH Program Announcement, PA-09-148, "Studies of Energy Balance and Cancer in Humans," we propose to address these gaps in knowledge by utilizing data from 2 National Cancer Institute-sponsored chemotherapy trials in newly diagnosed patients with stage IV colorectal cancer (CALGB 80203 and 80405) which provide a) prospective assessments of diet, medication, lifestyle and comorbidities; b) paraffin-embedded tumor specimens to examine how such factors interact with specific molecular alterations; c) blood samples for research purposes; and d) comprehensive data on cancer progression, mortality, and chemotherapy-related toxicity. Since stage, performance status, use of combination chemotherapy and follow-up were carefully defined in this trial, residual confounding by disease characteristics and use of chemotherapy should be minimized. This database will provide the unique opportunity to examine the influence of energy balance (Aim 1), diet and vitamin D (Aim 2) and aspirin/NSAIDs (Aim 3) on the outcomes of patients with advanced colorectal cancer. Beyond the aforementioned hypotheses, this cohort will allow for the rapid examination of future hypotheses as they emerge. Ultimately, this database will permit us to ascertain the influence of numerous factors on colorectal cancer survival, improve our understanding of colorectal cancer biology, and potentially offer substantive diet and lifestyle recommendations for patients and health care providers.

项目总结/摘要 流行病学和科学研究表明，饮食和其他生活方式的因素有显着 对结直肠癌发病风险的影响。新出现的数据表明，其中一些因素影响 对早期结肠癌患者的治疗效果。然而，没有数据表明， 饮食、生活方式和其他宿主因素对晚期结直肠癌患者预后的影响。在 在初次诊断时，20%的结直肠癌患者有转移的证据，另外15- 20%的患者会在初次诊断后的几年内复发。在过去的10年里， 这些患者的化疗选择有了实质性的改善， 超过2年，并且存活4年或以上的患者数量不断增加。患者往往寻求 了解什么，如果有的话，饮食和生活方式将改善他们的结果，生存和耐受性 疗法此外，饮食和生活方式如何影响预后可能部分取决于分子水平， 肿瘤的特征。作为对NIH项目公告的回应，PA-09-148，“能源研究 平衡和人类癌症，”我们建议通过利用来自2 美国国家癌症研究所在新诊断的IV期患者中申办的化疗试验 结肠直肠癌（CALGB 80203和80405），其提供a）饮食，药物， 生活方式和合并症; B）石蜡包埋的肿瘤标本，以检查这些因素如何相互作用 c）用于研究目的的血液样本;以及d）关于以下方面的全面数据： 癌症进展、死亡率和化疗相关毒性。由于阶段，性能状态，使用 联合化疗和随访在本试验中被仔细定义， 应尽量减少疾病特征和化疗的使用。该数据库将提供 独特的机会来检查能量平衡（目标1），饮食和维生素D（目标2）的影响， 阿司匹林/非甾体类抗炎药（目标3）对晚期结直肠癌患者预后的影响。超出 上述假设，这一队列将允许快速检查未来的假设，因为他们 出现。最终，这个数据库将使我们能够确定许多因素对结直肠癌的影响。 癌症生存，提高我们对结直肠癌生物学的理解，并可能提供实质性的 饮食和生活方式的建议，为病人和卫生保健提供者。