Adminstrative Core

项目总结（见说明）： 哈佛大学抗生素耐药性计划（HPAR）提案概述了一种新型跨学科合作伙伴关系的设计和功能，以开发和测试新的经验证的先导化合物，用于改变治疗多重耐药MRSA，VRE和现在的VRSA感染的范例。虽然发现和交付新的和有前途的新化合物的开发管道是一个主要的总体目标，因为这是一个学术努力，增加了科学知识的基础，支持这些病原体的抑制剂的发展;耐药性的理解，并开发新的新工具，研究宿主-病原体相互作用和多药耐药病原体也是主要目标。 这个项目是由一组有成就的科学家提出的，他们在细胞壁生物合成的生物化学和利用这种信息设计筛选和新的抑制剂方面具有丰富的经验;模式宿主系统的分子生物学和以新的方式利用这些系统筛选阻断细菌损害宿主能力的化合物;模型系统中生物膜形成的生物学和分子遗传学，以及使用该信息来鉴定生物膜破坏剂;肠球菌的发病机理、遗传学和抗生素抗性;多重耐药葡萄球菌感染的发病机制、分子生物学及临床治疗。这种科学专业知识是由行政经验，包括服务作为大学副校长研究，研究机构的总裁兼首席执行官的补充。HPAR管理核心的目标是创建一个比单个项目的总和更大的、具有凝聚力的、运行良好的整体。行政核心的具体目标是1）提供计划管理和监督，2）促进来自哈佛大学各组成部分的参与者之间的互动，3）为计划的财务管理提供关键基础设施; 4）提供与其他哈佛范围内的举措的连接和利用;和5）为与NIAID和项目官员以及其他NIAID倡议的持续沟通提供单一联系点和积极协调。

PROJECT SUMMARY (See instructions): This Harvard-wide Program on Antibiotic Resistance (HPAR) proposal outlines the design and function of a novel, interdisciplinary, collaborative partnership to develop and test new validated lead compounds for changing the paradigms for treatment of multidrug resistant MRSA, VRE and now VRSA infections. Although discovery and delivery of novel and promising new compounds to the development pipeline is a major overall goal, because this is an academic effort, adding to the base of scientific knowledge that underpins the development of inhibitors for these pathogens; the understanding of resistance, and development of novel new tools for studying host-pathogen interactions and multidrug resistant pathogens are also major goals. This project is being proposed by an accomplished group of scientists with extensive experience in the biochemistry of cell wall biosynthesis and use of that information to design screens and new inhibitors; the molecular biology of model host systems and the use of those systems in novel ways for screening compounds that block the ability of bacteria to harm the host; the biology and molecular genetics of biofilm formation in model systems and the use of that information to identify biofilm disrupting agents; the pathogenesis, genetics and antibiotic resistance of enterococci; and the pathogenesis, molecular biology and clinical treatment of infection caused by multidrug resistant staphylococci. This scientific expertise is complemented by administrative experience that includes service as university Vice President for Research, and President and CEO of a research institute. The goal of the HPAR Administrative Core is to create a cohesive and well functioning whole that is greater than the sum of the individual projects. The Specific Aims of the Administrative Core are to 1) Provide program management and oversight, 2) Facilitate interactions between participants from the various components of Harvard University, 3) Provide critical infrastructure for fiscal management of the program; 4) Provide connectivity to and leverage from other Harvard-wide initiatives; and 5) Provide a single point of contact and active coordination for on-going communication with NIAID and the Program Officer, and other NIAID initiatives.