Diagnostics Development Core

WRCE诊断开发核心支持并提高诊断效率 通过提供普遍适用的技术的共同访问，在WRCE内的发展项目， 共享试剂和动物模型，BSL-3和BSL-4诊断测试，以及专业咨询 服务两个诊断研讨会将由诊断开发核心组织。动物 来自疫苗和治疗项目的挑战样品将由核心收集，用于有效检测 诊断技术。技术开发活动包括开发专门的 分子识别试剂（例如，抗体和适体），以及微流体 将实验室检测转化为实用诊断平台的工具。共用试剂和动物 模型在经济上更有效，保护动物，并提高实验室间和实验室内的 实验诊断与金标准的比较以及相互之间的比较。此外，我们认为， RCE调查人员共同使用核心设施将有额外的好处， 超越个体实验室界限的科学对话。中央访问核心的BSL-3和 BSL-4测试设施允许使用毒性试剂对候选诊断进行实际测试， 个体调查员难以或甚至不可能以合理的费用访问。最后，专业化 关于将实验室技术转化为真正有用的平台诊断测试的建议， 由经验丰富的顾问提供给所有诊断主题研究者。

The WRCE Diagnostics Development Core supports and enhances the efficiency of diagnostics development projects within the WRCE by providing common access to generally-applicable technologies, shared reagents and animal models, BSL-3 and BSL-4 testing of diagnostics, and specialized consulting services. Two Diagnostics Workshops will be organized by the Diagnostics Development Core. Animal challenge samples from vaccine and therapeutic projects will be harvested by the Core for efficient testing of diagnostic technologies. Technology development activities include the development of specialized molecular recognition reagents (e.g., antibodies and aptamers) for neglected pathogens, and microfluidics tools for the conversion of laboratory assays into practical diagnostic platforms. Shared reagents and animal models are economically more efficient, conserve animals, and enhance inter- and intralaboratory comparisons of experimental diagnostics with gold standards and with each other. Moreover, we believe that common use of the core facilities by the RCE investigators will have the additional benefit of promoting scientific dialog beyond the boundaries of the individual laboratories. Central access to the Core's BSL-3 and BSL-4 testing facilities allows realistic testing of candidate diagnostics with virulent agents that would be difficult or even impossible for the individual investigator to access at reasonable cost. Finally, specialized advice on the translation of laboratory technologies into a genuinely useful platform diagnostic test will be provided by an experienced consultant to all diagnostics theme investigators.