Smartphone-based POC Testing for HIV Using Glowstick Chemistry

基于智能手机的 HIV 使用荧光棒化学进行 POC 测试

基本信息

  • 批准号:
    10594143
  • 负责人:
  • 金额:
    $ 45.65万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-01-06 至 2025-12-31
  • 项目状态:
    未结题

项目摘要

Effective testing for HIV allows for detection of acute infections (new and rebound), appropriate antiretroviral treatment, suppression of viral load, and interruption of transmission. However, early detection of infection or regular self-monitoring at point-of-need or at home remains a challenge. Lateral flow assays are a well-established, inexpensive point-of-need diagnostic method, and commonly are favored when applicable because of their ease of use and low cost. Where they most commonly fall short is in analytical sensitivity, notably in antigen-detection diagnostics for infectious diseases. Our goal is to develop radically-improved LFAs by implementing the inexpensive, shelf-stable chemi-excitation chemistry of glow sticks in a point-of-care format to excite fluors without light or optical filters. Our preliminary results suggest this chemistry enables LFAs with greatly improved limits of detection (very low pg/mL), using a standard smartphone with a $2 adaptor and no sophisticated optical components. Our central hypothesis is that our novel, reagent-optimized chemi-excited lateral flow assay technology integrated with a storage-stable reagent cartridge and readable with a smartphone will lead to a new, widely-useful and potentially very-superior class of highly-sensitive lateral flow assays. We will test this hypothesis through 5 specific aims: (1) Development of a highly-sensitive and easily-usable lateral flow assay for HIV p24 in human blood, including development of novel avidity-enhanced dual-fibronectin-domain binders, (2) Immune complex dissociation (ICD) for rebound/breakthrough HIV diagnosis, (3) Testing with 300 negative and archived-positive human samples from diverse cohorts, (4) To evaluate clinical performance using fresh samples from patients and usability with a diverse population of subjects at high risk of HIV infection/rebound (R33 Phase), (5) Easier usability by more people, quality assurance for test items (R33 Phase).
有效的艾滋病毒检测可以发现急性感染(新发和反弹),这是适当的

项目成果

期刊论文数量(0)
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Richard Willson其他文献

Richard Willson的其他文献

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{{ truncateString('Richard Willson', 18)}}的其他基金

Viral nanoparticles as ultrasensitive reporters in lateral-flow assays
病毒纳米粒子作为横流测定中的超灵敏报告基因
  • 批准号:
    8892732
  • 财政年份:
    2015
  • 资助金额:
    $ 45.65万
  • 项目类别:
Towards the Development of a Syndrome-specific Diagnostic Tool
开发针对特定症状的诊断工具
  • 批准号:
    8377050
  • 财政年份:
    2012
  • 资助金额:
    $ 45.65万
  • 项目类别:
Diagnostics Development Core
诊断开发核心
  • 批准号:
    8377038
  • 财政年份:
    2012
  • 资助金额:
    $ 45.65万
  • 项目类别:
Diagnostics Development Core
诊断开发核心
  • 批准号:
    8233009
  • 财政年份:
    2011
  • 资助金额:
    $ 45.65万
  • 项目类别:
Towards the Development of a Syndrome-specific Diagnostic Tool
开发针对特定症状的诊断工具
  • 批准号:
    8233015
  • 财政年份:
    2011
  • 资助金额:
    $ 45.65万
  • 项目类别:
Diagnostics Development Core
诊断开发核心
  • 批准号:
    7676468
  • 财政年份:
    2009
  • 资助金额:
    $ 45.65万
  • 项目类别:
Towards the Development of a Syndrome-specific Diagnostic Tool
开发针对特定症状的诊断工具
  • 批准号:
    7676538
  • 财政年份:
    2009
  • 资助金额:
    $ 45.65万
  • 项目类别:
THERMODYNAMIC BASIS OF ANTIBODY-ANTIGEN AFFINITY
抗体-抗原亲和力的热力学基础
  • 批准号:
    3468120
  • 财政年份:
    1990
  • 资助金额:
    $ 45.65万
  • 项目类别:
THERMODYNAMIC BASIS OF ANTIBODY-ANTIGEN AFFINITY
抗体-抗原亲和力的热力学基础
  • 批准号:
    2182486
  • 财政年份:
    1990
  • 资助金额:
    $ 45.65万
  • 项目类别:
THERMODYNAMIC BASIS OF ANTIBODY/ANTIGEN AFFINITY
抗体/抗原亲和力的热力学基础
  • 批准号:
    3468119
  • 财政年份:
    1990
  • 资助金额:
    $ 45.65万
  • 项目类别:

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