Diagnostics Development Core

诊断开发核心

• 批准号: 8377038
• 负责人: Richard Willson
• 金额: $ 51.1万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8377038
• 关键词: Affinity; Animal Model; Animals; Antibodies; Attenuated; Biological Assay; Categories; Consult; Core Facility; Development; Diagnostic; Diagnostic tests; Educational workshop; Emerging Communicable Diseases; Feedback; Goals; Gold; Harvest; Individual; Laboratories; Microfluidics; Monitor; Peptides; Reagent; Research; Research Personnel; Resource Sharing; Resources; Sampling; Services; Technology; Testing; Time; Translating; Translations; Virulent; aptamer; biodefense; cost; experience; innovation; molecular recognition; neglect; pathogen; practical application; product development; technology development; therapeutic vaccine; tool; working group

The WRCE Diagnostics Development Core supports and enhances the efficiency of diagnostics development projects within the WRCE by providing common access to generally-applicable technologies, shared reagents and animal models, BSL-3 and BSL-4 testing of diagnostics, and specialized consulting services. Two Diagnostics Workshops will be organized by the Diagnostics Development Core. Animal challenge samples from vaccine and therapeutic projects will be harvested by the Core for efficient testing of diagnostic technologies. Technology development activities include the development of specialized molecular recognition reagents (e.g., antibodies and aptamers) for neglected pathogens, and microfluidics tools for the conversion of laboratory assays into practical diagnostic platforms. Shared reagents and animal models are economically more efficient, conserve animals, and enhance inter- and intralaboratory comparisons of experimental diagnostics with gold standards and with each other. Moreover, we believe that common use of the core facilities by the RCE investigators will have the additional benefit of promoting scientific dialog beyond the boundaries of the individual laboratories. Central access to the Core's BSL-3 and BSL-4 testing facilities allows realistic testing of candidate diagnostics with virulent agents that would be difficult or even impossible for the individual investigator to access at reasonable cost. Finally, specialized advice on the translation of laboratory technologies into a genuinely useful platform diagnostic test will be provided by an experienced consultant to all diagnostics theme investigators.

WRCE 诊断开发核心支持并提高诊断效率 通过提供对通用技术的共同访问，在 WRCE 内开发项目， 共享试剂和动物模型、BSL-3 和 BSL-4 诊断测试以及专业咨询 服务。诊断开发核心将组织两次诊断研讨会。动物 来自疫苗和治疗项目的挑战样本将由核心收集，以进行有效的测试 诊断技术。技术开发活动包括开发专门的 用于被忽视的病原体的分子识别试剂（例如抗体和适体）和微流体 将实验室检测转化为实用诊断平台的工具。共用试剂和动物 模型在经济上更有效，保护动物，并增强实验室间和实验室内的能力 实验诊断与金标准以及相互之间的比较。此外，我们相信 RCE 调查人员共同使用核心设施将具有促进 科学对话超越了各个实验室的界限。集中访问核心的 BSL-3 和 BSL-4 测试设施允许使用有毒物质对候选诊断进行实际测试 个别调查员很难甚至不可能以合理的成本访问。最后，专门 关于将实验室技术转化为真正有用的平台诊断测试的建议将是 由经验丰富的顾问向所有诊断主题调查人员提供。