Diagnostics Development Core

诊断开发核心

• 批准号: 8377038
• 负责人: Richard Willson
• 金额: $ 51.1万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8377038
• 关键词: Affinity; Animal Model; Animals; Antibodies; Attenuated; Biological Assay; Categories; Consult; Core Facility; Development; Diagnostic; Diagnostic tests; Educational workshop; Emerging Communicable Diseases; Feedback; Goals; Gold; Harvest; Individual; Laboratories; Microfluidics; Monitor; Peptides; Reagent; Research; Research Personnel; Resource Sharing; Resources; Sampling; Services; Technology; Testing; Time; Translating; Translations; Virulent; aptamer; biodefense; cost; experience; innovation; molecular recognition; neglect; pathogen; practical application; product development; technology development; therapeutic vaccine; tool; working group

The WRCE Diagnostics Development Core supports and enhances the efficiency of diagnostics development projects within the WRCE by providing common access to generally-applicable technologies, shared reagents and animal models, BSL-3 and BSL-4 testing of diagnostics, and specialized consulting services. Two Diagnostics Workshops will be organized by the Diagnostics Development Core. Animal challenge samples from vaccine and therapeutic projects will be harvested by the Core for efficient testing of diagnostic technologies. Technology development activities include the development of specialized molecular recognition reagents (e.g., antibodies and aptamers) for neglected pathogens, and microfluidics tools for the conversion of laboratory assays into practical diagnostic platforms. Shared reagents and animal models are economically more efficient, conserve animals, and enhance inter- and intralaboratory comparisons of experimental diagnostics with gold standards and with each other. Moreover, we believe that common use of the core facilities by the RCE investigators will have the additional benefit of promoting scientific dialog beyond the boundaries of the individual laboratories. Central access to the Core's BSL-3 and BSL-4 testing facilities allows realistic testing of candidate diagnostics with virulent agents that would be difficult or even impossible for the individual investigator to access at reasonable cost. Finally, specialized advice on the translation of laboratory technologies into a genuinely useful platform diagnostic test will be provided by an experienced consultant to all diagnostics theme investigators.

WRCE诊断开发核心支持并提高诊断效率