Diagnostics Development Core

WRCE诊断开发核心支持并提高诊断效率 WRCE内的开发项目，通过提供对普遍适用技术的公共访问， 共享试剂和动物模型、BSL-3和BSL-4诊断测试以及专业咨询 服务。诊断开发核心将组织两个诊断研讨会。动物 核心将从疫苗和治疗项目中收集挑战样本，以便有效地测试 诊断技术。技术开发活动包括开发专门的 针对被忽视的病原体和微流体的分子识别试剂(例如抗体和适配子) 将实验室分析转化为实用诊断平台的工具。共享试剂和动物 模型在经济上更有效率，保护动物，并增强实验室内部和内部 实验诊断学与金标准以及彼此之间的比较。此外，我们认为， 区域经济委员会调查员共同使用核心设施将带来额外的好处，促进 超越单个实验室边界的科学对话。集中访问核心的BSL-3和 BSL-4测试设施允许使用毒性试剂对候选诊断进行现实测试， 个人调查员很难甚至不可能以合理的费用访问。最后，专业化 关于将实验室技术转化为真正有用的平台诊断测试的建议将是 由经验丰富的顾问提供给所有诊断主题调查人员。

The WRCE Diagnostics Development Core supports and enhances the efficiency of diagnostics development projects within the WRCE by providing common access to generally-applicable technologies, shared reagents and animal models, BSL-3 and BSL-4 testing of diagnostics, and specialized consulting services. Two Diagnostics Workshops will be organized by the Diagnostics Development Core. Animal challenge samples from vaccine and therapeutic projects will be harvested by the Core for efficient testing of diagnostic technologies. Technology development activities include the development of specialized molecular recognition reagents (e.g., antibodies and aptamers) for neglected pathogens, and microfluidics tools for the conversion of laboratory assays into practical diagnostic platforms. Shared reagents and animal models are economically more efficient, conserve animals, and enhance inter- and intralaboratory comparisons of experimental diagnostics with gold standards and with each other. Moreover, we believe that common use of the core facilities by the RCE investigators will have the additional benefit of promoting scientific dialog beyond the boundaries of the individual laboratories. Central access to the Core's BSL-3 and BSL-4 testing facilities allows realistic testing of candidate diagnostics with virulent agents that would be difficult or even impossible for the individual investigator to access at reasonable cost. Finally, specialized advice on the translation of laboratory technologies into a genuinely useful platform diagnostic test will be provided by an experienced consultant to all diagnostics theme investigators.