University of Guam/Cancer Research Center of Hawaii Partnership (2 of 2)

关岛大学/夏威夷癌症研究中心合作伙伴关系（2 of 2）

• 批准号: 8134420
• 负责人: Robert A Underwood
• 金额: $ 164.86万
• 依托单位: UNIVERSITY OF GUAM
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-28 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8134420
• 关键词: University; Guam; Cancer; Research; Center

DESCRIPTION (provided by applicant): Oral cancer is the sixth leading cancer in the world, and ranks in the top three cancers in countries where betel nut (also known as areca nut) chewing is common. In Micronesia, a group of Pacific Islands where betel nut is frequently chewed, the risk of oral cancer is elevated, but quite variable across populations. For the period 1985-1998 (age-adjusted to the 1988 U.S. population), the prevalence per 100,000 ranged from 4.2 in Chuuk to 31.8 in Yap. In Guam, the incidence of mouth cancer per 100,000 population for the period 1997-2003, age-adjusted to the 2000 U.S. population, varied between 8.1 for Chamorros to 17.9 among other Micronesians. The disparity in oral cancer rates among these populations may be due to differences in betel nut chewing patterns. To investigate the effect of chewing patterns, we must be able to conduct studies on multiple Micronesian islands with differing chewing patterns. Previously, we developed a comprehensive betel nut assessment protocol and a protocol for detecting oral lesions on Guam. The overall objectives of the pilot study are to further develop and test these methods, and to demonstrate that they can be applied in a research study of betel nut use on an island other than Guam. A convenience sample of 100 Micronesians (50 men and 50 women) who are long-term betel nut users (regular use for at least 10 years) will be recruited from the island of Saipan in the Commonwealth of the Northern Mariana Islands (CNMI). We will collect data on betel nut use, presence of oral precancerous lesions, diet, demographics, anthropometry, medical history, and physical activity. The specific aims of this study are to: 1) collect information on betel nut use among study participants and other members of their families, 2) perform oral examinations, and biopsies, as needed, on study participants, 3) measure other health risks among this population, including obesity, high blood pressure, self-reported history of cardiovascular disease and diabetes, and unhealthy dietary practices and 4) examine associations of duration, frequency, and type of betel nut use with oral pre-cancers and with other health risks. This pilot project will help formulate the research methods for studying betel nut use and disease risk in Micronesia, and will provide the necessary preliminary data for a full multi-island study of betel nut use and the prevalence of oral lesions. Ultimately, a better understanding of these associations will provide important new directions for reduction of health risks through educational efforts and targeted intervention strategies.

描述(申请人提供)：口腔癌是世界第六大癌症，在槟榔(又称槟榔)咀嚼普遍的国家，口腔癌位居前三位。在经常咀嚼槟榔的太平洋岛屿密克罗尼西亚，口腔癌的风险很高，但在不同人群中存在很大差异。在1985-1998年期间(根据1988年美国人口的年龄调整)，每10万人的流行率从丘克的4.2人到雅普的31.8人不等。在关岛，1997-2003年期间，根据2000年美国人口的年龄调整后，每10万人中口腔癌的发病率从查莫罗斯人的8.1到其他密克罗尼西亚人的17.9不等。这些人群中口腔癌发病率的差异可能是由于咀嚼槟榔的方式不同所致。为了研究咀嚼模式的影响，我们必须能够对多个具有不同咀嚼模式的密克罗尼西亚岛屿进行研究。在此之前，我们制定了一个全面的槟榔评估方案和一个在关岛检测口腔损害的方案。试点研究的总体目标是进一步开发和测试这些方法，并证明它们可以应用于关岛以外岛屿上槟榔使用的研究。将从北马里亚纳群岛(CNMI)的塞班岛招募100名长期使用槟榔(经常使用至少10年)的密克罗尼西亚人(50名男性和50名女性)作为便利样本。我们将收集槟榔的使用、口腔癌前病变的存在、饮食、人口统计学、人体测量、病史和体力活动的数据。这项研究的具体目的是：1)收集研究参与者及其家庭其他成员使用槟榔的信息，2)对研究参与者进行口腔检查，并根据需要对研究参与者进行活检，3)测量这些人群中的其他健康风险，包括肥胖、高血压、自我报告的心血管疾病和糖尿病病史，以及不健康的饮食习惯，以及4)检查槟榔使用时间、频率和类型与口腔癌症前期和其他健康风险的关系。这一试点项目将有助于制定研究密克罗尼西亚槟榔使用和疾病风险的研究方法，并将为对槟榔使用和口腔病变流行率进行全面多岛研究提供必要的初步数据。最终，更好地了解这些关联将为通过教育努力和有针对性的干预战略减少健康风险提供重要的新方向。