Biomaterials Dissemination

生物材料传播

• 批准号: 8328159
• 负责人: MITCHELL E GROSS
• 金额: $ 0.71万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8328159
• 关键词: Animal Model; Animals; Biocompatible Materials; Cells; Clinic; Clinical; Collection; Complex; Data; Exhibits; Generations; Goals; Human; Human Resources; Image; Institution; Intervention; Laboratories; Malignant Neoplasms; Modeling; Mus; Process; Research; Research Personnel; Research Project Grants; Resources; Sampling; Serum; Specimen; Study models; System; Therapeutic Agents; clinical phenotype; clinically relevant; design; leukemia/lymphoma; neoplastic cell; research study; response; tumor; virtual

The primary goal of Research Core 1 is to provide and coordinate acquisition of the basic biologic specimens to inform the modeling approaches across multiple part ofthis MC-START PSOC proposal. Integrated sample management is critical in order to allow for sample flow between inter-related research projects, particularly across multiple laboratories and institutions. To develop our virtual tumor, we have chosen to focus on a small number of genetically defined cancer systems which exhibit predictable response profiles to clinically relevant therapeutic agents and therefore represent major clinical phenotypes encountered In the clinic. Experiments are designed to extract a maximum amount of cell, tumor, and host level data from a minimum number of experimental animals both to best inform our modeling approaches and to conserve animal and personnel resources. The main focus of specimen acquisition efforts are murine leukemia and lymphoma models developed in the laboratory of Scott Lowe (CSHL, co-investigator RP4) which will be used to generate animals models in RP3, these animals will be used for imaging, treatment interventions, and biospecimen collection (serum, tumors) and curated by Research Core 1. Biologic specimens will then be disseminated to other projects for cell-level (RP1) and host level (RP4) analysis. Additional samples derived from human samples will be contributed by RP2. in all cases, biologic data will be used to inform the modeling approaches presented in each research project. In summary, the BioModel and Samples Core (Research Core 1) will to provide all investigators with high-quality, and uniform biologic data to inform the cell, tumor, and host-level modeling approaches over several iterative cycles across the MC-START research projects. The specific aims for Research Core 1 are: Specific Aim 1: Standardize Sample Processing and Storage within the MC-START. Specific Aim 2: Provide High-quality and Uniform Samples for Coordinated Analysis

研究核心 1 的主要目标是提供和协调基本生物样本的获取，以便为 MC-START PSOC 提案的多个部分的建模方法提供信息。为了实现相互关联的研究项目之间的样品流动，特别是跨多个实验室和机构的样品流动，集成样品管理至关重要。为了开发我们的虚拟肿瘤，我们选择 重点关注少数基因定义的癌症系统，这些系统对临床相关治疗药物表现出可预测的反应特征，因此代表了临床中遇到的主要临床表型。实验旨在从最少数量的实验动物中提取最多数量的细胞、肿瘤和宿主水平的数据，以便最好地为我们的建模方法提供信息并保存 动物和人员资源。样本采集工作的主要重点是 Scott Lowe（CSHL，联合研究员 RP4）实验室开发的小鼠白血病和淋巴瘤模型，这些模型将用于在 RP3 中生成动物模型，这些动物将用于成像、治疗干预和生物样本采集（血清、肿瘤），并由研究核心 1 进行管理。生物样本随后将传播到细胞水平的其他项目 (RP1) 和宿主级别 (RP4) 分析。派生额外样本 来自人类样本的数据将由 RP2 贡献。在所有情况下，生物数据将用于为每个研究项目中提出的建模方法提供信息。总之，生物模型和样本核心（研究核心 1）将为所有研究人员提供高质量、统一的生物学数据，以便在 MC-START 研究项目的多个迭代周期中为细胞、肿瘤和宿主水平的建模方法提供信息。 研究核心 1 的具体目标是： 具体目标 1：标准化 MC-START 内的样品处理和存储。 具体目标 2：为协调分析提供高质量且均匀的样品