Selective Cancer Treatment Based on High Frequency Ultrasonic Beam

基于高频超声波束的选择性癌症治疗

• 批准号: 9169556
• 负责人: MITCHELL E GROSS
• 金额: $ 24.04万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-16 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9169556
• 关键词: Acoustics; Affect; Animal Cancer Model; Animals; Architecture; Area; Caliber; Cancer Model; Cancerous; Cell Line; Cells; Cytolysis; Data; Deposition; Development; Devices; Diagnostic; Exposure to; Focused Ultrasound; Focused Ultrasound Therapy; Frequencies; Future; Goals; Heating; Histologic; Human; Image; In Vitro; Left; Length; Life; Liquid substance; Lithotripsy; Malignant - descriptor; Malignant Neoplasms; Medical Imaging; Membrane; Microbubbles; Monitor; Mus; Non-Malignant; Normal Cell; Normal tissue morphology; Organoids; Pattern; Penetration; Proliferating; Prostate; Research; Scanning; Self Tolerance; Shock; Skin Cancer; Skin Tissue; Solid; Spottings; Subcutaneous Tissue; System; Techniques; Technology; Testing; Therapeutic; Therapeutic Effect; Therapeutic Intervention; Thick; Tissues; Transducers; Translating; Ultrasonics; Ultrasonography; Variant; Violence; Work; Xenograft Model; absorption; base; cancer cell; cancer therapy; design; dosimetry; in vivo; killings; lens; melanoma; miniaturize; novel; operation; pressure; research study; sound; subcutaneous; transmission process; tumor; tumor growth; tumor xenograft

PROJECT SUMMARY/ABSTRACT The proposed research is to study radiant pressure effects of ultrasound on living tissues using animal models for cancer therapeutics. A major limitation of prior work regarding therapeutic effects of radiant pressure on cancer has been either too low acoustic intensity (in case of unfocused ultrasound produced with conventional transducers used for imaging) or too high acoustic intensity (in case of high-intensity focused ultrasound used to ablate tissue with thermal effects). Here, a novel Self-Focusing Acoustic Transducer (SFAT) capable of electrically varying the focal length and intensity will be used to deliver direct radiant pressure forces to living tissues, in the absence of thermal energy deposition or wide-spread cavitation formation, to preferentially kill cancer cells without damaging adjacent normal cells or tissue. Many studies have demonstrated that cancer cells are significantly more deformable (“less stiff”) than non-malignant counterparts. Our preliminary studies show that a focused acoustic beam within a specific energy range preferentially kills melanoma, prostate, and other cancer cells compared with non-tumorogenic matched cell lines. Further, our data supports that this is a direct result of fundamental differences in cytoskeletal architecture specific to malignant transformation. Thus, we propose studies to assess radiant pressure effects of highly focused US on normal and malignant tissue (as subcutaneous tumors and xenografts) in vivo. Since SFATs delivers the intended acoustic intensity only on its focal spot, it can produce unique effects at a local point without affecting other regions. Moreover, it is also capable of delivering acoustic energy through an intermediate solid or liquid, and is very well suited for non-invasive tumor treatment. Thus, the transducer and the scientific findings encountered on the way to its development will serve as a transformative technology broadly applicable for treatment of skin cancer and other malignancies.

项目总结/摘要 本研究拟利用动物实验研究超声对生物组织的辐射压力效应 癌症治疗的模型。关于辐射的治疗效果的先前工作的一个主要局限性 对癌症的压力要么是太低的声强度（在用超声产生的未聚焦超声的情况下）， 用于成像的常规换能器）或过高的声强度（在高强度聚焦的情况下 用于利用热效应消融组织的超声）。本文介绍了一种新型的自聚焦声换能器 （SFAT）能够电动改变焦距和强度将被用来提供直接辐射 在没有热能沉积或广泛空化的情况下，对活组织的压力 形成，以优先杀死癌细胞而不损害相邻的正常细胞或组织。 许多研究表明，癌细胞比癌细胞更易变形（“不那么僵硬”）。 非恶性对应物。我们的初步研究表明，一个特定的聚焦声束， 与非致瘤性相比，能量范围优先杀死黑色素瘤、前列腺和其他癌细胞 匹配的细胞系。此外，我们的数据支持，这是一个直接的结果，根本的差异， 恶性转化特有的细胞骨架结构。因此，我们建议研究评估辐射 高聚焦超声对正常和恶性组织（如皮下肿瘤和 异种移植物）。 由于SFAT仅在其焦点上提供预期的声学强度，因此它可以产生独特的效果 在不影响其他地区的情况下，此外，它还能够传递声能 通过中间固体或液体，并且非常适合于非侵入性肿瘤治疗。因此 传感器及其发展过程中遇到的科学发现将成为一个变革性的 该技术广泛适用于治疗皮肤癌和其他恶性肿瘤。