CD8 immunity to intracellular infection: Control by E-box transcription factors

CD8对细胞内感染的免疫:E-box转录因子的控制

基本信息

  • 批准号:
    8197099
  • 负责人:
  • 金额:
    $ 42.37万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-12-15 至 2012-11-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The CD8+ T cell response to intracellular pathogens such as bacteria, viruses and protozoan parasites is an essential component of host resistance. This proposal utilizes experimental infectious disease models of bacteria, Listeria monocytongenes, and Vaccinia virus to address questions about the host CD8+ T cell immune response against potential microbial agents of bioterrorism. We have discovered that E protein transcription factors and their inhibitor, Id2, regulate the CD8+ T cell response to intracellular pathogens, which is a novel function for these proteins. It is our goal to understand at a molecular level how this family of transcriptional regulators influences the activation, proliferation, differentiation and survival of CD8+ T cells as they transition from naove to effector to memory cells. While the E proteins are known to regulate many key developmental check-points, lineage commitment, proliferation and survival during hematopoiesis and lymphocyte development, the function of these important proteins is unexplored in the mature T cell. We hypothesize that the activation of CD8+ T cells and subsequent generation of memory cells during the immune response involves the regulation of E protein- transcriptional targets. To gain insight into the specific E protein-transcription factors that regulate gene expression, the genes which are regulated by their activity during the CD8+ T cell response and how the inhibition of their activity regulates memory T cell formation, we propose to: Aim 1: Determine which E proteins regulate the in vivo CD8+ T cell response. We will examine the immune response by E2A, E2-2 and HEB-deficient T cells and the DNA-binding activity of each of these proteins during infection with Listeria monocytogenes and Vaccinia virus. Aim 2: Identify the molecular pathways controlled by E protein-transcription factors during the in vivo CD8+ T cell immune response to infection. Aim 3: Create an Id2-reporter mouse line to define the Id2 expression pattern during the immune response and determine if Id2 expressing effector T cells are the precursors to memory T cells.
描述(由申请人提供):CD8+ T细胞对细胞内病原体(如细菌、病毒和原生动物寄生虫)的反应是宿主耐药性的重要组成部分。本研究利用细菌、单核增生李斯特菌和牛痘病毒的实验传染病模型来解决宿主CD8+ T细胞对潜在生物恐怖主义微生物病原体的免疫反应问题。

项目成果

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专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Ananda W Goldrath其他文献

Ananda W Goldrath的其他文献

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{{ truncateString('Ananda W Goldrath', 18)}}的其他基金

Ubiquitin ligase regulation of tissue-resident T cell and anti-tumor activity
泛素连接酶对组织驻留 T 细胞的调节和抗肿瘤活性
  • 批准号:
    10726015
  • 财政年份:
    2023
  • 资助金额:
    $ 42.37万
  • 项目类别:
Regulation of memory T cell differentiation and long-term maintenance
记忆T细胞分化和长期维持的调节
  • 批准号:
    10683278
  • 财政年份:
    2020
  • 资助金额:
    $ 42.37万
  • 项目类别:
Regulation of memory T cell differentiation and long-term maintenance
记忆T细胞分化和长期维持的调节
  • 批准号:
    10591871
  • 财政年份:
    2020
  • 资助金额:
    $ 42.37万
  • 项目类别:
Regulation of memory T cell differentiation and long-term maintenance
记忆T细胞分化和长期维持的调节
  • 批准号:
    10024589
  • 财政年份:
    2020
  • 资助金额:
    $ 42.37万
  • 项目类别:
Regulation of memory T cell differentiation and long-term maintenance
记忆T细胞分化和长期维持的调节
  • 批准号:
    10224894
  • 财政年份:
    2020
  • 资助金额:
    $ 42.37万
  • 项目类别:
Regulation of memory T cell differentiation and long-term maintenance
记忆T细胞分化和长期维持的调节
  • 批准号:
    10488590
  • 财政年份:
    2020
  • 资助金额:
    $ 42.37万
  • 项目类别:
Project 1 - Goldrath
项目1-戈德拉思
  • 批准号:
    10214455
  • 财政年份:
    2018
  • 资助金额:
    $ 42.37万
  • 项目类别:
Project 1 - Goldrath
项目1-戈德拉思
  • 批准号:
    10453791
  • 财政年份:
    2018
  • 资助金额:
    $ 42.37万
  • 项目类别:
Molecular Determinants of Tissue-resident Memory T cell Fate in Acute and Chronic Infection
急性和慢性感染中组织驻留记忆 T 细胞命运的分子决定因素
  • 批准号:
    10214451
  • 财政年份:
    2018
  • 资助金额:
    $ 42.37万
  • 项目类别:
Molecular Determinants of Tissue-resident Memory T cell Fate in Acute and Chronic Infection
急性和慢性感染中组织驻留记忆 T 细胞命运的分子决定因素
  • 批准号:
    10453786
  • 财政年份:
    2018
  • 资助金额:
    $ 42.37万
  • 项目类别:

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