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Preclinical Evaluation Of Neutralizing Antibodies Elicited by HIV-1 Immunogens

Preclinical Evaluation Of Neutralizing Antibodies Elicited by HIV-1 Immunogens
HIV-1 免疫原引发的中和抗体的临床前评估
批准号：
8556088
负责人：
John Mascola
金额：
$44.08万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8556088
关键词：
AdenovirusesAnimalsAntibodiesAntibody FormationAntigensDNAGlycoproteinsHIV-1ImmunizationMacaca mulattaProteinsRecombinantsRegimenStructureVaccinesbaseneutralizing antibodynovelplasmid DNApreclinical evaluation

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英文摘要
The present studies examine the breadth and magnitude of neutralizing antibody responses in small animals and rhesus monkeys after various immunization regimens. Using a standardized multi-tier panel of reference Env pseudoviruses for neutralizing antibody assessment, we show that both protein immunization, and DNA prime, rAd boost immunization, can generate high antibody titers. Ongoing studies are evaluating novel immunogens based on structure-based information from studies of the HIV-1 envelope glycoprotein.
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Next Generation Development of Broadly Neutralizing HIV Antibodies for Prevention
HIV/AIDS Vaccine and Antibody Development
Pre-clinical Vaccine Development for Respiratory Viruses
Pre-clinical Vaccine and Antibody Development for Coronavirus Disease 2019 (COVID-19)
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