ETIOLOGY OF COPD AMONG CONSTRUCTION WORKERS
建筑工人慢性阻塞性肺病的病因
基本信息
- 批准号:8179841
- 负责人:
- 金额:$ 37.76万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-09-01 至 2014-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): Twelve million people in the US have diagnosed chronic obstructive pulmonary disease (COPD). COPD is the fourth leading cause of death in the US and is responsible for more than 130,000 deaths annually. At least 15% of COPD cases are attributable to occupational exposures; however, relatively little is known about specific occupational exposure agents that increase the risk of COPD or interactions of occupational exposures and other risk factors such as cigarette smoking. We propose to conduct a case-control study of COPD among construction and craft workers identified at high risk of COPD through preliminary studies. The study includes a broad spectrum of construction crafts with numerous and varied exposures to occupational agents of interest. This study will include approximately 1500 COPD cases and 1500 grouped-matched controls selected from a population of over 15,000 workers undergoing occupational medicine examinations provided by the Building Trades National Medical Screening Program (BTMED), supported by the US Department of Energy. Cases and controls will complete a telephone interview to determine all jobs held more than six months, performance of specific tasks in these jobs, and exposures to agents thought to increase COPD. A panel of three experienced industrial hygienists will conduct exposure assessments of jobs and tasks reported by study participants. Detailed analyses will identify exposures that increase COPD risk and evaluate interactions of occupational risk factors with personal factors such as smoking, prior respiratory history, hobby- related exposures, and family history of COPD. Combining data from the BTMED examinations with detailed information on exposures from the interview questionnaire is innovative and provides a unique opportunity to learn more about specific exposures increasing COPD risk. This study addresses many of the limitations of prior studies of COPD and occupation including: 1) low statistical power due to small populations with low numbers of COPD cases, 2) COPD cases not based on spirometry, 3) exposure assessments often simply based on job title, occupation, or industry, and 4) limited data on non-occupational risk factors such as cigarette smoking, obesity, medical history, family history, and hobby-related activities. The research team is comprised of experienced occupational lung disease researchers with a long history of productive collaboration.
PUBLIC HEALTH RELEVANCE: COPD is a major public health problem with an estimated 12 million people in the US with diagnosed COPD and 12 million with undiagnosed COPD. More than 130,000 deaths occur annually in the US due to COPD. Occupational exposures are estimated to cause at least 15% of all COPD cases; however, little is known about specific agents and combinations of agents that increase risk. Knowledge of causative agents is key to development of appropriate prevention programs. This study addresses this public health information gap.
描述(由申请人提供):美国有1200万人被诊断为慢性阻塞性肺疾病(COPD)。COPD是美国第四大死因,每年造成超过130,000人死亡。至少有15%的COPD病例可归因于职业暴露;然而,对于增加COPD风险的特定职业暴露剂或职业暴露与其他风险因素(如吸烟)的相互作用,我们知之甚少。 我们建议对通过初步研究确定为COPD高风险的建筑和工艺工人进行COPD病例对照研究。这项研究包括广泛的建筑工艺与众多和不同的接触感兴趣的职业代理人。该研究将包括大约1500例COPD病例和1500名分组匹配对照,这些病例和对照是从接受由美国能源部支持的建筑行业国家医学筛查计划(BTMED)提供的职业医学检查的15,000多名工人中选出的。病例和对照组将完成电话访谈,以确定所有超过6个月的工作,这些工作中特定任务的执行情况,以及被认为会增加COPD的药物暴露。一个由三名经验丰富的工业企业家组成的小组将对研究参与者报告的工作和任务进行暴露评估。详细分析将确定增加COPD风险的暴露,并评价职业风险因素与个人因素(如吸烟、既往呼吸道病史、爱好相关暴露和COPD家族史)的相互作用。 将BTMED检查的数据与访谈问卷中有关暴露的详细信息相结合是一种创新,并提供了一个独特的机会来了解更多有关增加COPD风险的特定暴露的信息。这项研究解决了以前COPD和职业研究的许多局限性,包括:1)由于COPD病例数量少的人群少,统计功效低,2)COPD病例不基于肺量测定法,3)暴露评估通常仅基于职称、职业或行业,以及4)关于非职业风险因素(如吸烟、肥胖、病史、家族史)的数据有限,和爱好相关的活动。该研究团队由经验丰富的职业性肺病研究人员组成,具有长期的富有成效的合作历史。
公共卫生相关性:COPD是一个主要的公共卫生问题,在美国估计有1200万人患有确诊的COPD,1200万人患有未确诊的COPD。在美国,每年有超过130,000人死于COPD。据估计,职业暴露导致至少15%的COPD病例;然而,对增加风险的特定药物和药物组合知之甚少。了解病原体是制定适当预防方案的关键。这项研究解决了这一公共卫生信息差距。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
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{{ truncateString('JOHN M DEMENT', 18)}}的其他基金
SURVEILLANCE METHODS FOR HEALTH CARE AND RELATED WORKERS
医疗保健及相关工作人员的监测方法
- 批准号:
6259528 - 财政年份:2001
- 资助金额:
$ 37.76万 - 项目类别:
SURVEILLANCE METHODS FOR HEALTH CARE AND RELATED WORKERS
医疗保健及相关工作人员的监测方法
- 批准号:
6598055 - 财政年份:2001
- 资助金额:
$ 37.76万 - 项目类别:
SURVEILLANCE METHODS FOR HEALTH CARE AND RELATED WORKERS
医疗保健及相关工作人员的监测方法
- 批准号:
6775570 - 财政年份:2001
- 资助金额:
$ 37.76万 - 项目类别:
SURVEILLANCE METHODS FOR HEALTH CARE AND RELATED WORKERS
医疗保健及相关工作人员的监测方法
- 批准号:
6751163 - 财政年份:2001
- 资助金额:
$ 37.76万 - 项目类别:
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