Exploring the relationship of Vitamin D and childhood brain tumors

探索维生素 D 与儿童脑肿瘤的关系

• 批准号: 8241359
• 负责人: Parveen Bhatti
• 金额: $ 8.8万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-16 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8241359
• 关键词: Adult; Age-Months; Animals; Archives; Astrocytoma; Biological Markers; Birth Certificates; Birth Weight; Blood; Brain Neoplasms; Cancer Etiology; Case-Control Studies; Cessation of life; Child; Childhood; Childhood Brain Neoplasm; Cholecalciferol; Data; Databases; Development; Diagnostic; Disease; Ependymoma; Epidemiology; Ethnic Origin; Etiology; Fostering; Future; Gestational Age; Goals; Health; Histology; Human; Intervention; Lead; Link; Malignant Childhood Neoplasm; Malignant Neoplasms; Measurement; Measures; Mission; Neonatal; Neonatal Screening; Pathogenesis; Pregnancy; Pregnant Women; Primitive Neuroectodermal Tumor; Public Health; Race; Research; Research Personnel; Resources; Risk; Risk Factors; Specimen; Spottings; Temperature; Testing; Time; Vitamin D; Vitamin D Deficiency; Vitamin D2; Vitamins; aging brain; base; burden of illness; cancer risk; improved; in utero; innovation; insight; modifiable risk; neoplasm registry; population based; prenatal smoking; prevent; programs; season of birth; sex

DESCRIPTION (provided by applicant): Low circulating levels of vitamin D [25-(OH)D] have been associated with various adult onset cancers. However, studies of childhood cancer have not been conducted despite compelling experimental and epidemiologic evidence suggesting that reduced vitamin D during gestational development may be a risk factor, particularly for childhood brain tumors (CBT). For CBT, the in utero period of development has been shown to be a critical time window of exposure. Neonatal dried blood spots (DBS) collected and archived as part of newborn screening programs represent a unique resource for examining pre-diagnostic 25-(OH)D in relation to childhood cancers and allows for focus on the impact of vitamin D during the in utero time period. The long-term goal is to understand the pathogenesis of CBT so that interventions can be developed to reduce the burden of this disease among children. The overall objective for this application, which is a step toward attainment of the long term goal, is to examine the association between neonatal 25-(OH)D, as measured in DBS, with risk of CBT. The central hypothesis of the proposed study is that vitamin D deficiency during pregnancy is associated with increased risk of CBT. The hypothesis will be tested by pursuing two specific aims 1) Evaluate among 250 childhood brain tumor cases and 250 controls the association between 25-(OH)D, as measured in DBS as a marker of gestational circulating vitamin D levels, and the risk of CBT; 2) In exploratory analyses, determine if the association between 25-(OH)D and brain tumor risk differs by sex, race/ethnicity, prenatal smoking, maternal SES, brain tumor histology, birth weight, gestational age and month and season of birth. This study is innovative because it will, for the first time, examine circulating vitamin D levels as predictors of CBT risk by using measurements in DBS as markers of in utero vitamin D levels. The proposed research is significant because it is expected to provide valuable data that will ultimately lead to efficacious targets for interventions to mitigate the occurrence of CBT. PUBLIC HEALTH RELEVANCE: The proposed research is relevant to public health because few modifiable risk factors have been identified for childhood brain tumors, the leading cause of cancer death among children. Vitamin D deficiency is a promising modifiable risk factor that may ultimately be a target for intervention to prevent this disease. Thus, the proposed research is relevant to the part of the NIH's mission that pertains to fostering research that will ultimately protect and improve human health.

描述（由申请人提供）：维生素 D [25-(OH)D] 循环水平低与各种成人发病的癌症有关。然而，尽管令人信服的实验和流行病学证据表明妊娠发育期间维生素 D 的减少可能是一个危险因素，特别是对于儿童脑肿瘤 (CBT)，但尚未对儿童癌症进行研究。对于 CBT 而言，子宫内发育期已被证明是暴露的关键时间窗口。作为新生儿筛查计划的一部分收集和存档的新生儿干血斑 (DBS) 是检查与儿童癌症相关的诊断前 25-(OH)D 的独特资源，并可重点关注维生素 D 在子宫内时期的影响。长期目标是了解 CBT 的发病机制，以便制定干预措施来减轻儿童这种疾病的负担。此应用程序的总体目标是实现长期目标的一步 术语目标是检查 DBS 测量的新生儿 25-(OH)D 与 CBT 风险之间的关联。该研究的中心假设是怀孕期间维生素 D 缺乏与 CBT 风险增加相关。该假设将通过追求两个具体目标进行检验：1) 评估 250 例儿童脑肿瘤病例和 250 例对照病例之间的 25-(OH)D（在 DBS 中测量，作为妊娠循环维生素 D 水平的标志物）与 CBT 风险之间的关联； 2) 在探索性分析中，确定 25-(OH)D 与脑肿瘤风险之间的关联是否因性别、种族/民族、产前吸烟、母亲 SES、脑肿瘤组织学、出生体重、胎龄以及出生月份和季节而异。这项研究具有创新性，因为它将首次通过使用 DBS 测量值作为子宫内维生素 D 水平的标记来检查循环维生素 D 水平作为 CBT 风险的预测因子。拟议的研究意义重大，因为它有望提供有价值的数据，最终形成有效的干预目标，以减轻 CBT 的发生。 公共健康相关性：拟议的研究与公共健康相关，因为对于儿童脑肿瘤（儿童癌症死亡的主要原因），几乎没有发现可改变的危险因素。维生素 D 缺乏症是一种很有前途的可改变的危险因素，最终可能成为预防这种疾病的干预目标。因此，拟议的研究与 NIH 使命的一部分相关，即促进最终保护和改善人类健康的研究。